Association between relative temporal and prefrontal sulcal cerebrospinal fluid and illness duration in schizophrenia

Molina, Vicente; Reig, Santiago; Sanz, Javier; Benito, Carlos; Pascau, Javier; Collazos, Francisco; Sarramea, Fernando; Artaloytia, Juan Francisco; Gispert, Juan Domingo; Molina-Luque, Rafael

doi:10.1016/s0920-9964(02)00166-4

Cited by 20 publications

(11 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found an inverse association between gray matter loss in prefrontal areas and hippocampal hypermetabolism that has also been observed in recent onset and chronic patients with schizophrenia [183]. This corticolimbic system dysregulation is discussed in the light of triggering psychotic symptoms [184]. There are numerous studies investigating neural correlates of hallucination [185,186] in schizophrenia, mostly emphasizing regions of the (prominently left) Heschl's gyrus and the planum temporale (for a review of structural and functional changes in these areas see ref.…”

Section: Schizophreniamentioning

confidence: 81%

Functional Neuroimaging in Memory and Memory Disturbances

Reinhold¹,

Kuehnel²,

Brand³

et al. 2006

CMIR

View full text Add to dashboard Cite

During the past years brain imaging techniques like positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) became more and more important for gaining new insights into processes of and circuits for memory encoding and retrieval. These findings also had a great impact on a better understanding of memory dysfunctions and their underlying brain mechanisms. In the present review, data on memory dysfunctions are analyzed separately according to whether they are of an organic, or a psychiatric psychogenic etiology. Studies examining patients with various forms of amnesia and dementia, for whom functional brain imaging data were available, indicate early functional brain changes. These early changes differ from subsequent structural brain changes and therefore support the clinical and diagnostic use of functional brain imaging techniques in memory disturbances. Furthermore, research outcomes from patients suffering from psychogenic amnesias (dissociative amnesias) and psychogenic fugue conditions are summarized. Finally, differences and similarities between organic amnesia and psychogenic amnesia are discussed with regard to the present literature and exemplified with two single cases from our lab.

show abstract

Section: Schizophreniamentioning

confidence: 81%

Functional Neuroimaging in Memory and Memory Disturbances

Reinhold¹,

Kuehnel²,

Brand³

et al. 2006

CMIR

View full text Add to dashboard Cite

show abstract

“…To perform the metabolic and volumetric measurements of CSF for the regions of interest (ROIs), a two-step procedure was adopted [11,24]. The first step involved editing the MRI to remove skull and extracranial tissue and an initial segmentation of cerebral tissues into gray matter (GM), white matter (WM), and CSF.…”

Section: Image Analysismentioning

confidence: 99%

“…Excessive amounts of cortical CSF have consistently been found in schizophrenia [1,6,7,13,24,33], in particular in the frontal region [6,24]. If this CSF excess would be progressive a significant association with illness duration would be expected.…”

Section: Introductionmentioning

confidence: 99%

Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia

Molina¹,

Sanz

Sarramea

et al. 2005

Eur. psychiatr.

View full text Add to dashboard Cite

show abstract

“…In these early studies, patients received typical antipsychotics (TA) during the follow-up period. In similar populations, also treated with TA, a significant association was noted between illness duration and the excess of volume in frontal and temporal sulcal cerebrospinal fluid spaces (Molina et al 2002, Turetsky et al 1995, suggesting a sustained progression of GM loss in that areas, filled up with cerebrospinal fluid. Finally, an inverse association between the frontal signal of N-acetylaspartate, considered a marker of the amount of viable neuronal tissue (Urenjak et al 1993) and disease duration (Ende et al 2000, Molina et.…”

Section: Effect Of the Type On Antipsychotic On The Outcome Of Corticmentioning

confidence: 91%

Structural effects of atypical antipsychotics: Implications for the meaning of cortical volume deficit in schizophrenia

Molina¹

2005

Eur. J. Psychiat.

View full text Add to dashboard Cite

Patients with schizophrenia have a smaller volume of cortex than healthy controls. Nevertheless, the substrate of such deficit is not well understood A progressive loss of cortical GM in schizophrenia seemed supported by early studies with magnetic resonance imaging (MRI) in which patients received typical drugs between the baseline and final scans. However, recent MRI results challenge this notion and suggest that structural changes may depend, at least in part, on the type of treatment received. These data may be relevant for a correct interpretation of the substrate of cortical volume deficit in schizophrenia. If that deficit can be even reversed by treatment, as suggested by recent studies, a neuronal substrate seems unlikely. Several lines of evidence instead support that glia cells may have a role in cortical structural and functional deficits in schizophrenia, which would be also in agreement with recent longitudinal results with MRI in patients treated with atypical antipsychotics. These evidences are reviewed in this paper.

show abstract

Association between relative temporal and prefrontal sulcal cerebrospinal fluid and illness duration in schizophrenia

Cited by 20 publications

References 41 publications

Functional Neuroimaging in Memory and Memory Disturbances

Functional Neuroimaging in Memory and Memory Disturbances

Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia

Structural effects of atypical antipsychotics: Implications for the meaning of cortical volume deficit in schizophrenia

Contact Info

Product

Resources

About