Association between REM sleep behavior disorder and impulsive–compulsive behaviors in Parkinson’s disease: a systematic review and meta-analysis of observational studies

Lü, Haitao; Shen, Qiuyan; Zhao, Quanzhen; Huang, Hongyan; Ning, Pingping; Wang, Hui; Xie, Dan; Xu, Yanming

doi:10.1007/s00415-019-09588-3

Cited by 16 publications

(12 citation statements)

References 43 publications

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“…In a recent study on early PD patients followed for 3 years, the prevalence of ICBs was not associated with RBD, but only with DA use, apathy, and severity of motor fluctuations, according to a multiple imputation analysis 17 . Recently, a meta‐analysis including 10 observational cross‐sectional studies and involving data from 2,781 PD patients found that RBD was associated with a >2‐fold increased risk of developing ICBs, even after stratifying subgroups based on methods for diagnosing RBD and ICBs 18 . Finally, another longitudinal analysis was recently performed using the PPMI cohort data, finding that pRBD at BL was an independent predictor of ICD development over time 19 .…”

Section: Discussionmentioning

confidence: 99%

“…However, 3 other studies, using either a questionnaire or standard criteria to diagnose both RBD and ICBs, did not find this association 15–17 . A recent meta‐analysis, including 10 observational cross‐sectional studies and involving a total of 2,781 PD patients, found that RBD was associated with a >2‐fold higher risk of having ICBs, and the same result was obtained after stratifying subgroups based on methods for diagnosing RBD and ICBs 18 …”

Section: Introductionmentioning

confidence: 98%

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Is Rapid Eye Movement Sleep Behavior Disorder a Risk Factor for Impulse Control Disorder in Parkinson Disease?

Fantini

Fedler

Pereira³

et al. 2020

Annals of Neurology

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Objective: To assess the association between rapid eye movement sleep behavior disorder (RBD) and other determinants and incident impulse control disorder behaviors (ICBs) in patients with early Parkinson disease (PD) using longitudinal data from the Parkinson's Progression Markers Initiative. Methods: Four hundred one newly diagnosed PD patients were prospectively evaluated at baseline (BL), month 6, and annually for 5 years. Probable RBD (pRBD) was assessed with the RBD Screening Questionnaire (RBDSQ) and dichotomized using a cutoff value of ≥6. The association of BL and time-dependent (TD) pRBD and other covariates with the development of ICB symptoms was evaluated using Cox proportional hazards regression and general estimating equation logistic regression. Models considered adjustment for age, sex, Movement Disorders Society Unified Parkinson's Disease Rating Scale part III, Geriatric Depression Scale (GDS-15), RBD medication use, total levodopa equivalent daily dose, and dopamine agonist (DA) and antidepressant medication use. Results: Both BL pRBD and TD pRBD were not associated with an increased risk for incident ICB symptoms after adjustment for covariates (adjusted hazard ratio [HR] = 1.17, p = 0.458 and HR = 1.27, p = 0.257, respectively). In a modified TD pRBD model (ie, considering subjects as pRBD onward from the first time point with RBDSQ score ≥ 6), the risk for incident ICB symptoms was higher in pRBD in unadjusted (HR = 1.48, p = 0.038) but not adjusted (HR = 1.29, p = 0.203) models. TD DA use (HR = 1.64, p = 0.039), TD GDS-15 score (HR = 1.12, p < 0.001), and male sex (year 3: HR = 2.10, p = 0.009; year 4: HR = 3.04, p = 0.006; year 5: HR = 4.40, p = 0.007) were associated with increased ICB symptom risk. Interpretation: pRBD is not clearly associated with ICB symptom development in early PD, in contrast to DA use, depression, and male sex.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Is Rapid Eye Movement Sleep Behavior Disorder a Risk Factor for Impulse Control Disorder in Parkinson Disease?

Fantini

Fedler

Pereira³

et al. 2020

Annals of Neurology

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“…Thus, RBD that has been reported to be associated with a more J o u r n a l P r e -p r o o f severe phenotype, [39] including cognitive impairment, [40,41] and with a specific psychobehavioral profile, probably associated with a specific pattern of neurodegeneration leading to an increased risk of impulsive behaviors in PD. [7,42]…”

Section: Igt In Pdmentioning

confidence: 99%

“…[4,5] REM sleep behavior disorder (RBD), a parasomnia that can precede for several years PD motor signs, has been reported to be associated with an increased risk to develop ICDs. [6,7] Although, this remains debated and the mechanisms underlying this putative association are still poorly understood. [8] and could be related to a specific psychobehavioral profile leading to ICDs, including psychological traits such as cognitive impulsivity and psycho-behavioral decision making impairments.…”

Section: Introductionmentioning

confidence: 99%

Decision making under uncertainty in Parkinson's disease with Rem sleep behavior disorder

et al. 2022

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“…Downloaded from two. 54 However, the majority of included studies diagnosed RBD on a screening questionnaire. Of the three studies using gold-standard polysomnography, S45-s47 only one S45 found an association between the PD-ICB and RBD.…”

Section: Clinical and Demographic Modellingmentioning

confidence: 99%

Spectrum of impulse control behaviours in Parkinson’s disease: pathophysiology and management

Kelly¹,

Baig

Hu³

et al. 2020

J Neurol Neurosurg Psychiatry

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Impulse control behaviours (ICBs) are a range of behaviours linked by their reward-based, repetitive natures. They can be precipitated in Parkinson’s disease (PD) by dopamine replacement therapy, often with detrimental consequences for patients and caregivers. While now a well-recognised non-motor feature of treated PD, much remains unknown about the influence of risk factors, pathophysiological mechanisms, vulnerability factors for specific types of behaviour and the optimal management strategies. Imaging studies have identified structural and functional changes in striatal and prefrontal brain regions, among others. Gene association studies indicate a role for genetic predisposition to PD-ICB. Clinical observational studies have identified potential modifiable and non-modifiable risk factors. Psychological studies shed light on the neurocognitive domains implicated in PD-ICBs and identify psychosocial determinants that may perpetuate the cycle of impulsive and harm-avoidance behaviours. Based on these results, a range of pharmacological and non-pharmacological management strategies have been trialled in PD-ICBs with varying success. The purpose of this review is to update clinicians on the evidence around the pathophysiology of PD-ICB. We aim to translate our findings into an interpretable biopsychosocial model that can be applied to the clinical assessment and management of individual cases of PD-ICB.

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Association between REM sleep behavior disorder and impulsive–compulsive behaviors in Parkinson’s disease: a systematic review and meta-analysis of observational studies

Cited by 16 publications

References 43 publications

Is Rapid Eye Movement Sleep Behavior Disorder a Risk Factor for Impulse Control Disorder in Parkinson Disease?

Is Rapid Eye Movement Sleep Behavior Disorder a Risk Factor for Impulse Control Disorder in Parkinson Disease?

Decision making under uncertainty in Parkinson's disease with Rem sleep behavior disorder

Spectrum of impulse control behaviours in Parkinson’s disease: pathophysiology and management

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