Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

Uematsu, Fumiyuki; Kikuchi, Hideaki; Motomiya, Masakichi; Abé, Tatsuya; Sagami, Ikuko; Ohmachi, Tetsuo; Wakui, A; Kanamaru, Ryunosuke; Watanabe, Minro

doi:10.1111/j.1349-7006.1991.tb01838.x

Cited by 199 publications

(90 citation statements)

References 10 publications

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“…However, there are also indications of genetic predisposition to lung cancer (reviewed by Sellers, 1996;Lichtenstein et al, 2000) with some evidence that smoking-related cases are associated with polymorphisms in CYP2 genes involved in the metabolic activation of procarcinogens in cigarette smoke (Uematsu et al, 1991). If differences in carcinogen metabolism underlie susceptibility to lung cancer, these differences would not be detected by the G 2 assay.…”

Section: Discussionmentioning

confidence: 99%

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

et al. 2001

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SummaryWe previously found that 40% of breast cancer patients showed enhanced sensitivity to X-ray induced chromosome damage in G 2 lymphocytes and suggested that this might indicate a low penetrance predisposition to breast cancer, for which there is good epidemiological evidence. We have now tested the hypothesis that elevated G 2 radiosensitivity is a marker of such predisposition to other common cancers. We tested patients with colorectal cancer, for which there is also good epidemiological evidence of inherited risk in a substantial proportion of cases, and patients with cancers having a strong environmental aetiology (lung and cervix). We also repeated our study of breast cancer cases and tested patients with chronic diseases other than cancer. The results support our hypothesis, in that 30% (12/37) of colorectal cases showed enhanced sensitivity compared with 9% (6/66) of normal healthy controls (P = 0.01), whereas the proportions of sensitive cervix (11%, 3/27, P = 0.72) and lung cancer cases (23%, 8/35, P = 0.07) were not significantly above normals. We confirmed the enhanced sensitivity of 40% (12/31, P = 0.001) of breast cancer patients and found that patients with non-malignant disease had a normal response in the assay (12%, 4/34, P = 0.73). We suggest that enhanced G 2 chromosomal radiosensitivity is a consequence of inherited defects in the ability of cells to process DNA damage from endogenous or exogenous sources, of a type that is mimicked by ionizing radiation, and that such defects predispose to breast and colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

et al. 2001

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“…44) Individuals with the variant Rsa1 allele have a lower basal CYP2E1 activity. Overrepresentation of the variant CYP2E1 Rsa1 and Dra1 alleles was reported in Japanese 13,14,45) and a lower frequency of the Dra1 variant allele was found in lung cancer patients than in controls. A study in Japanese also found a 13.5% allele frequency for the rare CYP2E1 Pst1 site among all lung cancer patients and a significant association between the variant CYP2E1 Pst1 allele and lung AC.…”

Section: Discussionmentioning

confidence: 99%

Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: A case‐control study in Chinese population

Wang

Deng

et al. 2003

Cancer Science

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A case-control study of 164 lung adenocarcinoma (AC) patients with 181 age-and gender-matched healthy controls was conducted in order to assess any associations between glutathione-Stransferase M1 (GSTM1), cytochrome P4501A1 (CYP1A1) and cytochrome P4502E1 (CYP2E1) polymorphisms and susceptibility to lung AC in Chinese. The presence of CYP2E1 variant allele was significantly less frequent in cases than in controls, while the distribution of GSTM1 null genotype and variant CYP1A1 Msp1 allele did not vary between cases and controls. After adjustment for age, gender, smoking and all other genotypes, the CYP2E1 Rsa1 variant allele was significantly associated with decreased risk of lung AC [odds ratio 0.534 (95% confidence interval, 0.340-0.837)]. Furthermore, 3.0-fold increased risk was found in individuals with combined GSTM1 null genotype and CYP2E1 Rsa1 wild type versus those with combined GSTM1 non-null type and CYP2E1 variant allele. Our results suggest that CYP2E1 Rsa1 variant allele is associated with a decreased risk of lung AC, and combined GSTM1 null genotype and CYP2E1 Rsa1 wild type has a promoting effect on susceptibility to lung AC. (Cancer Sci 2003; 94: 448-452) hile lung cancer incidence is now decreasing in men in some countries, it still remains a major worldwide health problem, accounting for more than one-sixth of cancer deaths. 1) Furthermore, the incidence and proportion of lung adenocarcinoma (AC) cases have been increasing for several decades in many Asian, American and European countries, leading to a changing clinical picture characterized by early development of metastases.It is well established that lung cancers in men and women are largely attributable to cigarette smoking, and the trend for elevation of lung AC is also considered to be related to an increase in exposure to tobacco-specific nitrosamines (TSNAs) from low-tar cigarettes. However, it has also been reported that only less than 20% of smokers develop lung cancer, suggesting that genetic variations and other environmental factors also play important roles in determining individual differences in lung cancer susceptibility. 2)Genetic variations in metabolic activation or detoxification enzymes are thought to make a major contribution, including polymorphisms in glutathione-S-transferase M1 (GSTM1), cytochrome P4501A1 (CYP1A1) and cytochrome P4502E1 (CYP2E1). Although many studies have shown that GSTM1 null genotype and variant CYP1A1 alleles are associated with an increased risk of lung squamous cell carcinoma (SCC) independent of the ethnic background, the results regarding lung AC risk are still contradictory.3-11) A number of studies have also investigated the association of the genetic polymorphism of CYP2E1 with lung cancer, but the effects remain unclear. 6,[12][13][14][15][16][17][18][19][20][21][22] In the Chinese population, lung cancer is the leading cause of cancer deaths, and while SCC is still the predominant histological type, the rate for lung AC is increasing and AC is already the most common histological t...

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“…Common homozygote (TT), heterozygote (TA), and rare homozygote (AA) genotypes of CYP2E1*6 were named DD, DC, and CC, respectively. CYP2E1*6 doesn't affect gene transcription, but it is likely to affect CYP2E1 catalytic activity (Uematsu et al, 1991). CYP2E1*7B (rs6413420; G-71T) was also found in the promoter region of the gene.…”

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confidence: 94%

CYP2E1^5B, CYP2E1^6, CYP2E1^7B, CYP2E1^2, and CYP2E1^*3 Allele Frequencies in Iranian Populations

Shahriary

Galehdari²,

Jalali³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

Cited by 199 publications

References 10 publications

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: A case‐control study in Chinese population

CYP2E1^5B, CYP2E1^6, CYP2E1^7B, CYP2E1^2, and CYP2E1^*3 Allele Frequencies in Iranian Populations

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Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

Cited by 199 publications

References 10 publications

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: A case‐control study in Chinese population

CYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 Allele Frequencies in Iranian Populations

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CYP2E1^5B, CYP2E1^6, CYP2E1^7B, CYP2E1^2, and CYP2E1^*3 Allele Frequencies in Iranian Populations