Association between rheumatoid arthritis and genetic variants of natural resistance‐associated macrophage protein 1 gene: A meta‐analysis

Wang, Hong; Yuan, Feifei; Dai, Ziwei; Wang, Bin; Ye, Dong‐Qing

doi:10.1111/1756-185x.13366

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…p<0.10 indicated a significant Q-statistic and the existence of within-and between-study variation I 2 statistic values from 0 to 100%; 25%, 50%, and 75% represent low, moderate, and high heterogeneity, respectively. 18 The pooled ORs and their 95% CIs were obtained by using a random effect model in case of significant heterogeneity (p<0.10 or I 2 >50%). Otherwise, a fixed-effect model (p<0.10 or I 2 >50%) was used in this meta-analysis.…”

Section: Evaluation Of Statistic Associationmentioning

confidence: 99%

Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases: a meta-analysis

Wang¹,

Wang²,

Wu³

et al. 2021

aei

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Objective: To systematically evaluate the association between TBX21 gene polymorphisms (rs17250932, rs2240017, and rs4794067) and the risk of autoimmune diseases in Asian populations.Methods: The Medline, Web of Science, and Chinese Biomedical Literature Database were used to retrieve eligible studies that were published before July 2020. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the dominant model, heterozygote contrast model, and allelic contrast model. Publication bias was evaluated using contour-enhanced funnel plots and Egger’s regression test. Sensitivity analysis was conducted to assess the robustness of this meta-analysis.Results: A total of 12 eligible studies including 3834 patients and 4824 healthy controls were recruited in this meta-analysis. The pooled data demonstrated that TBX21 rs2240017 and rs4794067 polymorphisms are significantly associated with the risk of autoimmune diseases in Asian populations in allelic contrast model (OR: 1.456, 95% CI: 1.131–1.875, p=0.004; OR: 0.766, 95% CI: 0.615–0.954, p=0.017), heterozygote comparison model (OR: 1.647, 95% CI: 1.239–2.189, p=0.001; OR: 0.796, 95% CI: 0.634–0.999, p=0.049), and dominant mode (OR: 1.572, 95% CI: 1.194–2.071, p=0.004; OR: 0.767, 95% CI: 0.607–0.970, p=0.027). The G allele of rs2240017 may be a risk factor for autoimmune diseases and the T allele of rs4794067 may increase the risk of autoimmune diseases. However, we failed to find evidence of the association between TBX21 rs17250932 polymorphism and susceptibility to autoimmune diseases. No publication bias was found in this meta-analysis.Conclusions: This meta-analysis indicated that TBX21 rs2240017 and rs4794067 polymorphisms confer susceptibility to autoimmune diseases, but not rs17250932.

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Section: Evaluation Of Statistic Associationmentioning

confidence: 99%

Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases: a meta-analysis

Wang¹,

Wang²,

Wu³

et al. 2021

aei

Self Cite

View full text Add to dashboard Cite

show abstract

“…P < 0.10 indicated a significant Q statistic and the existence of within-and between-study variation I 2 statistic values from 0 to 100%; 25%, 50%, and 75% represented a low, moderate, and high heterogeneity, respectively. 18 The pooled OR values and their 95% CIs were obtained by using random effect model in case of significant heterogeneity (P < 0.10 or I 2 > 50%), otherwise a fixed effect model (P < 0.10 or I 2 > 50%) was used in this meta-analysis.…”

Section: Evaluation Of Statistic Associationmentioning

confidence: 99%

Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases

Wang

et al. 2021

aei

Self Cite

View full text Add to dashboard Cite

Objective: To evaluate systematically the association between TBX21 gene polymorphisms (rs17250932, rs2240017, and rs4794067) and the risk of autoimmune diseases in Asian populations. Methods: The Medline, Web of Science, and Chinese Biomedical Literature Database were used to retrieve eligible studies that were published before July 2020. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated by using the dominant model, heterozygote contrast model, and allelic contrast model. Publication bias was evaluated using contour-enhanced funnel plots and Egger’s regression test. Sensitivity analysis was conducted to assess the robustness of this meta-analysis.Results: A total of 12 eligible studies, including 3834 patients and 4824 healthy controls, were recruited in this meta-analysis. The pooled data demonstrated that TBX21 rs2240017 and rs4794067 polymorphisms were significantly associated with the risk of autoimmune diseases in Asian populations in allelic contrast model (OR: 1.456, 95% CI: 1.131–1.875, P = 0.004; OR: 0.766, 95% CI: 0.615–0.954, P = 0.017), heterozygote comparison model (OR: 1.647, 95% CI: 1.239–2.189, P = 0.001; OR: 0.796, 95% CI: 0.634–0.999, P = 0.049), and dominant model (OR: 1.572, 95% CI: 1.194–2.071, P = 0.004; OR: 0.767, 95% CI: 0.607–0.970, P = 0.027). The G allele of rs2240017 may be a risk factor for autoimmune diseases, and the T allele of rs4794067 may increase the risk of autoimmune diseases. However, we failed to find evidence of the association between TBX21 rs17250932 polymorphism and susceptibility to autoimmune diseases. No publication bias was established in this meta-analysis.Conclusion: This meta-analysis indicated that TBX21 rs2240017 and rs4794067 polymorphism confer susceptibility to autoimmune diseases, but not rs17250932.

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“…Beyond Crohn's, human diseases associated with MAP have been pursued due to the identification of genetic susceptibility risk that is shared for both the specific disease and for mycobacterial infection. Searches for polymorphisms of the CARD15 (NOD2) [46][47][48], SLC11a1 (NRAMP1) [49][50][51], LRRK2 [52,53], PTPN2/22 [54] and VDR [55] genes have been productive as they reveal susceptibilities for infection by mycobacteria due to impaired pathogen recognition or failure of phagosome maturation. Polymorphisms of these genes have been linked to MAP infection and concomitant diseases: Crohn's disease [46,50], multiple sclerosis [46,56], Blau syndrome [46], autoimmune (Hashimoto's) thyroiditis [57][58][59], Parkinson's disease [52,60], rheumatoid arthritis [50,54,61], lupus [62] and T1D [55,63].…”

Section: Mycobacterium Avium Ss Paratuberculosis-mapmentioning

confidence: 99%

Proposing BCG Vaccination for Mycobacterium avium ss. paratuberculosis (MAP) Associated Autoimmune Diseases

Dow

2020

Microorganisms

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Bacille Calmette–Guerin (BCG) vaccination is widely practiced around the world to protect against the mycobacterial infection tuberculosis. BCG is also effective against the pathogenic mycobacteria that cause leprosy and Buruli’s ulcer. BCG is part of the standard of care for bladder cancer where, when given as an intravesicular irrigant, BCG acts as an immunomodulating agent and lessens the risk of recurrence. Mycobacterium avium ss. paratuberculosis (MAP) causes a fatal enteritis of ruminant animals and is the putative cause of Crohn’s disease of humans. MAP has been associated with an increasingly long list of inflammatory/autoimmune diseases: Crohn's, sarcoidosis, Blau syndrome, Hashimoto’s thyroiditis, autoimmune diabetes (T1D), multiple sclerosis (MS), rheumatoid arthritis, lupus and Parkinson’s disease. Epidemiologic evidence points to BCG providing a “heterologous” protective effect on assorted autoimmune diseases; studies using BCG vaccination for T1D and MS have shown benefit in these diseases. This article proposes that the positive response to BCG in T1D and MS is due to a mitigating action of BCG upon MAP. Other autoimmune diseases, having a concomitant genetic risk for mycobacterial infection as well as cross-reacting antibodies against mycobacterial heat shock protein 65 (HSP65), could reasonably be considered to respond to BCG vaccination. The rare autoimmune disease, relapsing polychondritis, is one such disease and is offered as an example. Recent studies suggesting a protective role for BCG in Alzheimer’s disease are also explored. BCG-induced energy shift from oxidative phosphorylation to aerobic glycolysis provides the immunomodulating boost to the immune response and also mitigates mycobacterial infection—this cellular mechanism unifies the impact of BCG on the disparate diseases of this article.

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Association between rheumatoid arthritis and genetic variants of natural resistance‐associated macrophage protein 1 gene: A meta‐analysis

Cited by 6 publications

References 32 publications

Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases: a meta-analysis

Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases: a meta-analysis

Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases

Proposing BCG Vaccination for Mycobacterium avium ss. paratuberculosis (MAP) Associated Autoimmune Diseases

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