ABSTRACT. Objective: The purpose of this study was to examine changes and predictors of changes in riding with an alcohol/drugimpaired driver (RWI) from 10th grade through the fi rst post-high school year. Method: Transition models were used to estimate the association of four waves (W1-W4) of RWI with W4 environmental-status variables and time-varying covariates in the NEXT Generation Health Study, a nationally representative cohort of U.S. 10th graders (N = 2,785). Results: Overall, 33% (weighted) of adolescents reported RWI in the past 12 months in W1, and slightly declined in W2 (24%), W3 (27%), and W4 (26%). Across time, transition models with generalized estimating equations showed that RWI was more likely among those who previously reported RWI (ORs from 3.62 to 3.66, p < .001), substance use (ORs from 1.81 to 1.82, p < .001), and heavy episodic drinking (ORs from 1.85 to 1.86, p < .001). Those living on college campuses were somewhat more likely to engage in RWI (OR = 1.38, .05 < p <.10) than those living at home. The effects of parental monitoring knowledge and peer alcohol/ substance use on RWI were suppressed when individual substance use and heavy episodic drinking were taken into consideration. Conclusions: Substance use and heavy episodic drinking in previous waves and the history of RWI were persistent factors of RWI in a dynamic pattern. The setting in which emerging adults live during their fi rst post-high school year could affect their engagement in RWI. The fi ndings suggest that harm-reduction strategies should focus on the identifi cation of early RWI coupled with reduction of substance use and heavy episodic drinking. (J.