Association between rosacea and smoking: A systematic review and meta‐analysis

Yuan, Xin; Yin, Dan

doi:10.1111/dth.14747

Cited by 9 publications

(11 citation statements)

References 25 publications

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“…The risk of the disease in active smokers was lower than in the general population, while it was higher in people who quit smoking. Maculopapular and hypertrophic types were more often observed in smokers [34].…”

Section: Dietamentioning

confidence: 88%

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Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

Woźniacka¹,

Czuwara²,

Krasowska³

et al. 2022

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EPIDEMIOLOGyRosacea is diagnosed on the basis of morphological criteria, hence there is a view that the reported incidence of the disease is lower than the actual one, especially in the case of its mild course or in people with a high skin phototype. However, it is not a rare disease, as it affects about 5% of the world's population. There is controversy in the literature regarding the prevalence of rosacea among men and women. Some authors indicate that the incidence of the disease is similar, while others emphasize that it affects women more often. Rosacea is usually diagnosed in adults between 30 and 50 years of age. Most often the disease occurs in people with fair skin, living in the northwestern part of Europe, mainly Irish, Scots and Celts with I or II skin phototype, or their relatives. It should be emphasized, however, that in about 10% of EPIDEMIOLOGIA Trądzik różowaty rozpoznawany jest na podstawie kryteriów morfologicznych, dlatego też istnieje pogląd, że raportowana częstość występowania choroby jest niższa od rzeczywistej, zwłaszcza w przypadku jej łagodnego przebiegu lub u osób z wysokim fototypem skóry. Nie jest to jednak choroba rzadka, ponieważ dotyczy około 5% osób na świecie. W piśmiennictwie istnieją kontrowersje dotyczące częstości występowania rosacea wśród mężczyzn i kobiet. Część autorów wskazuje, że częstość występowania choroby jest podobna, inni podkreślają, że częściej dotyczy kobiet. Trądzik różowaty rozpoznawany jest zwykle u osób dorosłych, pomiędzy 30. a 50. rokiem życia. W większości występuje u ludzi z niskim fototypem, zamieszkujących północno-zachodnie krańce Europy, głównie Irlandczyków, Szkotów i Celtów

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Section: Dietamentioning

confidence: 88%

“…U aktywnych palaczy ryzyko rozwoju choroby było mniejsze od populacyjnego, natomiast zwiększone u osób, które zaprzestały palenia. U palaczy częściej obserwowano typ grudkowo-krostkowy oraz przerostowy [34].…”

Section: Palenie Tytoniu a Trądzik Różowatyunclassified

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

Woźniacka¹,

Czuwara²,

Krasowska³

et al. 2022

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“…These controversial ndings can be explained by the microvascular constriction caused by the nicotine in tobacco (43). To be noted, based on a systematic review and meta-analysis conducted in 2020, this protective effect of current smoking on the risk of rosacea may be temporary (44). Regarding the severity of the disease, Alinia et al reported a signi cant relationship between the severity of rosacea and number of cigarettes smoked in patients who had quit smoking (45).…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between smoking behaviors and rosacea and Acne: Evidence from a Mendelian randomization

Gohari,

Golmohammadi,

Saeidian

et al. 2024

Preprint

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Previous observational studies have demonstrated positive associations between smoking patterns and the prevalence of acne and rosacea. However, the possible causal relationship remained unclear. Therefore, we conducted a Mendelian randomization (MR) study to investigate the potential causal association between smoking and these two common chronic inflammatory skin disorders. The summary statistics dataset related to smoking initiation and smoking behaviors were gathered from the published Genome-wide association study (GWAS) of 462,690 participants in the UK Biobank. The genetic variants associated with acne and rosacea were also obtained from the published GWAS of the FinnGen consortium which included 7,072,771 and 20,169,986 SNPs, respectively. Using these data, we conducted a two-sample MR analysis to determine the causal relationship between smoking behaviors and acne and rosacea. Our results show that lifetime smoking is significantly associated with a higher risk of acne (beta = 0.23, 95%; CI = (0.03, 0.43), SE = 0.10, Pbeta =0.02). Heterogeneity and pleiotropy tests revealed no evidence of heterogeneity or pleiotropy. However, no significant association was observed between smoking initiation and the risk of acne (beta = 0.02, 95%; CI (0.12, 0.14), SE = 0.073, Pbeta =0.71) (MR–Egger intercept = 0.013, P-value = 0.15). Despite no signs of pleiotropy, evidence of heterogeneity was found. Regarding rosacea, our findings determine a significant correlation between smoking behaviors, including smoking initiation and lifetime smoking, and an elevated risk of rosacea (beta = 0.34; 95% CI (0.11, 1.47), SE = 0.15, Pbeta= 0.02) (beta = 0.79; 95% CI (0.11, 1.47), SE = 0.34, Pbeta= 0.02). No evidence of heterogeneity or pleiotropy was also observed. Our study suggests a causal relationship between smoking behaviors and both acne and rosacea. These findings can be beneficial in terms of providing additional perspectives on healthcare decision policies.

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“…A case-control study in the U.K. reported that smoking was associated with a substantially reduced risk of developing rosacea ( 5 ). Furthermore, a recent meta-analysis demonstrated that current smoking was associated with a decreased risk of rosacea ( 6 ). However, a study conducted in Turkey presented contradictory findings, they reported a significantly higher risk of developing rosacea, particularly the erythema of subtype 1 rosacea, among smokers ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…These discrepancies are likely attributed to the inherent limitations of observational studies, including the non-randomized design, residual confounding, and the possibility of reverse causation. For example, the above-mentioned meta-analysis on smoking and rosacea risk primarily used case-control studies, which may be susceptible to recall bias in the included data ( 6 ). Additionally, it is worth noting that the largest study included in the meta-analysis was conducted among patients on antihypertensives, which could potentially introduce bias in the assessment of rosacea cases.…”

Section: Introductionmentioning

confidence: 99%

The impact of smoking and alcohol consumption on rosacea: a multivariable Mendelian randomization study

Chu,

Yi,

Yan

et al. 2024

Front. Public Health

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BackgroundsObservational studies have shown that cigarette smoking is inversely associated with risk of rosacea, However, it remains uncertain whether this association is causal or it is a result of reverse causation, and whether this association is affected by drinking behaviors.MethodsThis study utilized the summary-level data from the largest genome-wide association study (GWAS) for smoking, alcohol consumption, and rosacea. The objective was to investigate the effect of genetically predicted exposures to smoking and alcohol consumption on the risk of developing rosacea. Two-sample bidirectional Mendelian randomization (MR) was applied, accompanied by sensitive analyses to validate the robustness of findings. Furthermore, multivariable MR was conducted to evaluate the direct impact of smoking on rosacea.ResultsA decreased risk of rosacea was observed in individuals with genetically predicted lifetime smoking [odds ratio (OR)MR − IVW = 0.53; 95% confidence interval (CI), 0.318–0.897; P = 0.017], and number of cigarettes per day (ORMR − IVW = 0.55; 95% CI, 0.358–0.845; P = 0.006). However, no significant associations were found between initiation of regular smoking, smoking cessation, smoking initiation, alcohol consumption and rosacea. Reverse MR analysis did not show any associations between genetic liability toward rosacea and smoking or alcohol drinking. Importantly, the effect of lifetime smoking and the number of cigarettes per day on rosacea remained significant even after adjusting for alcohol consumption in multivariable MR analysis.ConclusionSmoking was causally related to a lower risk of rosacea, while alcohol consumption does not appear to be associated with risk of rosacea.

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Association between rosacea and smoking: A systematic review and meta‐analysis

Cited by 9 publications

References 25 publications

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

The causal relationship between smoking behaviors and rosacea and Acne: Evidence from a Mendelian randomization

The impact of smoking and alcohol consumption on rosacea: a multivariable Mendelian randomization study

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