Association between rs10046, rs1143704, rs767199, rs727479, rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms in aromatase (CYP19A1) gene and Alzheimer’s disease risk: a systematic review and meta-analysis involving 11,051 subjects

Aromatase ( CYP19A1 ) gene variants, sex steroid levels, and late‐life depression

“…The TT minor homozygote was associated with an increased risk compared to CC or TC but the confidence intervals were large due to the small numbers. Given the potential genetic associations between CYP19A1 and age-related pathologies Shay et al, 2018;Song et al, 2019;Wang et al, 2016;Westberg & Eriksson, 2008), it seems conceivable that certain genes may be specifically associated with late-life depression. No significant associations were found with the three other SNPs they investigated, including rs749292.…”

“…In contrast with depression, a number of studies have examined the associations between several CYP19A1 variants and cognitive impairment or Alzheimer's disease Song et al, 2019). Aromatase expression and activity is necessary for proper neurobehavioral development in males and females.…”

“…For women, hormonal fluctuations throughout reproductive life, especially at menopause, can also result in mood disorder (Ancelin et al, 2007). Given the potential genetic associations between CYP19A1 and age-related pathologies Shay et al, 2018;Song et al, 2019;Wang et al, 2016;Westberg & Eriksson, 2008), it seems conceivable that certain genes may be specifically associated with late-life depression.…”

“…Later in life, sex differences in aromatase may affect neurological diseases such as depression and Alzheimer's disease, which tend to be more frequent in females than males . In contrast with depression, a number of studies have examined the associations between several CYP19A1 variants and cognitive impairment or Alzheimer's disease Song et al, 2019). A recent meta-analysis examined eight polymorphisms in the CYP19A1 gene, of which rs10046 and rs767199 but not rs1065778 and rs1062033, weakly increased Alzheimer's disease susceptibility.…”

“…CYP19A1 polymorphisms were chosen based on common (MAF≥0.05) tag SNPs identified using the Haploview program (Barrett, Fry, Maller, & Daly, 2005), and Caucasian genotype data from the International HapMap Project (www.hapmap.org; version3_releaseR2, ethnicity: CEU+TSI). The most commonly studied SNPs previously associated with depression (Kravitz, Janssen, et al, 2006a) or other neuropsychiatric disorder (Butler et al, 2010;Corbo, Gambina, Ulizzi, Moretto, & Scacchi, 2009;Iivonen et al, 2004;Janicki et al, 2013;Kravitz, Meyer, et al, 2006b;Medway et al, 2014;Rosenfeld et al, 2018;Shay et al, 2018;Song et al, 2019) were selected, whereas ensuring adequate coverage across the gene.…”