Association between rs1049174 <i>NKG2D</i> gene polymorphism and idiopathic recurrent spontaneous abortion in Iranian women: a case-control study

Asl, Amir Abdian; Nezamdoust, Fereshteh Vaziri; Fesahat, Farzaneh; Astani, Akram; Barati, Meisam; Raee, Pourya; Asadi-Saghandi, Abolghasem

doi:10.1080/01443615.2020.1798906

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…[19,20] In addition to medication, high-quality nursing interventions play a pivotal role during the treatment period to ensure the effectiveness of medication treatment. [21–24]…”

Section: Discussionmentioning

confidence: 99%

“…[19,20] In addition to medication, high-quality nursing interventions play a pivotal role during the treatment period to ensure the effectiveness of medication treatment. [21][22][23][24] Continued precision care, extending beyond discharge, not only aids medical staff in promptly understanding changes in the patient's condition and adjusting medication but also enhances the patient's knowledge of threatened abortion and improves their self-management abilities. [25][26][27] This study revealed that participants receiving continued precision care intervention exhibited lower scores in emotional state assessments, including tension-anxiety, depression-dejection, anger-hostility, vigoractivity, fatigue-inertia, and confusion-bewilderment, compared to those receiving routine care intervention.…”

Section: Discussionmentioning

confidence: 99%

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Effect of extended precision nursing on neurobehavioral function and pregnancy outcome in patients with threatened abortion

Shen,

Wei,

et al. 2024

Medicine

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This study aimed to assess the impact of continuous precision nursing on neurobehavioral function and pregnancy outcomes in patients experiencing threatened abortion. A total of 130 patients with early threatened abortion admitted to our hospital between October 2020 and January 2023 were selected and categorized into 2 groups based on intervention methods. The control group received routine nursing intervention, whereas the observation group received continuous precision nursing intervention. Changes in affective status scores, SF-36 scores, knowledge mastery scores, and satisfaction scores in the neurobehavioral function test before and after intervention were recorded in both groups. Additionally, pregnancy outcomes, obstetric adverse reaction rates, and neonatal conditions were documented. Following intervention, scores for tension–anxiety, depression–dejection, anger–hostility, vigor–activity, fatigue–inertia, and confusion–bewilderment gradually decreased in both groups, with significantly lower scores observed in the observation group compared to the control group (P < .05). SF-36 scores in 8 dimensions, including physical functioning, role-physical, bodily pain, and overall health rating, showed a gradual increase in both groups, with the observation group scoring higher than the control group (P < .05). Knowledge mastery and satisfaction scores also increased significantly after intervention, with the observation group surpassing the control group (P < .05). The observation group exhibited lower rates of abortion and premature birth, along with a higher rate of full-term pregnancy compared to the control group, with statistically significant differences (P < .05). Furthermore, the observation group displayed lower rates of adverse reactions and low birth weight infants, with significant differences compared to the control group (P < .05). No significant differences were observed in neonatal mortality and neonatal intensive care unit transfer rates between the observation and control groups (P > .05). Continuous precision nursing contributes to improved pregnancy outcomes for patients with threatened miscarriage within the first 12 weeks of pregnancy. This comprehensive care approach is associated with enhanced knowledge retention, protection of neurological function, and an overall improvement in quality of life.

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“…[19,20] In addition to medication, high-quality nursing interventions play a pivotal role during the treatment period to ensure the effectiveness of medication treatment. [21–24]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of extended precision nursing on neurobehavioral function and pregnancy outcome in patients with threatened abortion

Shen,

Wei,

et al. 2024

Medicine

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“…The rs2617170 TT genotype showed a significant association with protective effect against RM in north African fertile women [81]. The frequency of rs1049174 GG genotype and G allele was higher among Iranian women after recurrent miscarriages compared with controls [71]. Successful inhibition of the cytotoxic immune activity might be a thera-peutic option, as well as intravenous immunoglobulin method in secondary RM cases, respectively [189].…”

Section: Pregnancy Miscarriagementioning

confidence: 98%

“…Carrying the HNK1/HNK1 and HNK1/LNK1 haplotypes is associated with significantly increased NKG2D protein surface expression on NK cells and reduced overall cancer risk, compared to the LNK1/LNK1 haplotype [57,89]. CC homozygosity associated with higher risk of EBV-infected nasopharyngeal carcinoma in Vietnamese patients [67] GG genotype in chronic hepatitis C Iranian patients demonstrated higher response to Peginterferon Alfa-2a/Ribavirin therapy against HCV infection [68] No association between Caucasian alleles and CMV infection in the first year after kidney transplantation [69] Donor GG genotype associated with improved overall survival and transplant related mortality in Japanese patients with standard risk disease after HLA-fully matched unrelated BM transplantation; no impact on disease relapse or development of aGvHD, cGvHD [70] C allele associated with decreased risk of recurrent miscarriages among Iranian women [71] rs2255336 (A, C > G, T)…”

Section: Variability Of the Nkg2d Gene-its Functional Effect And Clinical Associationsmentioning

confidence: 99%

NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications

Siemaszko

Marzec-Przyszlak

Bogunia‐Kubik

2021

Cells

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Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings.

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Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation

Siemaszko,

Łacina,

Szymczak

et al. 2024

Human Immunology

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Association between rs1049174 NKG2D gene polymorphism and idiopathic recurrent spontaneous abortion in Iranian women: a case-control study

Cited by 5 publications

References 40 publications

Effect of extended precision nursing on neurobehavioral function and pregnancy outcome in patients with threatened abortion

Effect of extended precision nursing on neurobehavioral function and pregnancy outcome in patients with threatened abortion

NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications

Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation

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