Association between rs2188380 and the risk of breast cancer in southwest Chinese population

Abstract

BackgroundPrevious studies have revealed that the single nucleotide polymorphism (SNP) rs2188380 was identified as a novel locus of gout. Interestingly, gout resulting from high serum uric acid (SUA) was also identified to be associated with the risk of breast cancer (BC). We hypothesized that maybe there was a relationship between rs2188380 and the risk of BC. Therefore, our study was conducted to investigate whether this novel gout‐related SNP (rs2188380) was associated with BC risk as well as the clinical and pathological characteristics in the southwest Chinese population.Materials and methodsWe performed a case‐control study including 104 breast cancer patients and 112 healthy controls to investigate whether rs2188380 is associated with BC risk in the southwest Chinese population. The genotyping was performed by the SNP scan method. General characteristics and clinicopathological characteristics of tumors were also included in the analysis. The statistical evaluations were performed using the Student t test, the chi‐square test or Fisher's exact test, and unconditional logistic regression analysis.ResultsThe C/C genotype of rs2188380 might be related to BC risk to some extent compared with G/G genotype (OR = 9.241, 95% CI = 1.122‐76.101, P = 0.039). Furthermore, after adjusting the age, the association still existed (OR = 8.788, 95% CI = 1.063‐72.636, P = 0.044). However, no significant association was observed between rs2188380 and the clinicopathological characteristics of BC.ConclusionsOur study primarily indicated that rs2188380 might have a potential association with BC risk to some extent. With a limited sample size and statistical power, further studies based on larger populations are needed to confirm the association.

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

“…The high CYP4B1 expression increased the chances of bioactivation of carcinogenic aromatic amines, thereby leading to a high risk of cancer growth [ 15 – 17 ]. Gene mutations are associated with protein expression levels, and gene polymorphisms may play a role in disease susceptibility by affecting gene expression and/or enzyme activity [ 18 , 19 ]. Previous studies have reported that CYP4B1 polymorphisms are significantly correlated with the risk of various cancers, such as gastric cancer [ 20 ], bladder cancer [ 21 ], and lung cancer [ 22 ].…”