Association between Sarcopenia, Sarcopenic Obesity, and Chronic Disease in Korean Elderly

Lim, Hee‐Sook; Park, Yoon‐Hyung; Suh, Kyoil; Yoo, Myung Hi; Park, Hyeong Kyu; Kim, Hye Jeong; Lee, Jae-Hyuk; Byun, Dong Won

doi:10.11005/jbm.2018.25.3.187

Cited by 56 publications

(60 citation statements)

References 17 publications

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“…Several studies have reported a close correlation between SO and dyslipidemia. One study from Korea showed that the ORs of dyslipidemia increased by 1.12 and 1.50 in the sarcopenia and SO groups, respectively, compared with the values of a nonsarcopenia group [38]. Another study that included 1231 men aged > 70 years reported that serum triglyceride levels were higher in patients with SO than in those with pure sarcopenia and nonsarcopenic nonobesity [39].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria

Xiao-dong²,

Xie

et al. 2019

BMC Endocr Disord

125

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BackgroundSarcopenia and sarcopenic obesity (SO) have a greater impact on the elderly. This study aimed to explore whether there were sex differences in the prevalence and adverse outcomes of sarcopenia and SO in community-dwelling elderly individuals in East China.MethodsThis was a cross-sectional study that enrolled 213 males and 418 females aged > 65 years. Demographic characteristics, body composition, hand grip, gait speed, and indices of glucose and lipid metabolism were collected. Sarcopenia and SO were diagnosed using the Asian Working Group for Sarcopenia criteria.Results(1) The prevalence of sarcopenia was 19.2% in males and 8.6% in females. The prevalence of SO was 7.0% in males and 2.4% in females. (2) In males, the odds ratios (ORs) of osteoporosis and dyslipidemia in the SO group were 4.21-fold and 4.15-fold higher than those in the normal group, respectively. In females, the ORs of osteoporosis and hyperglycemia in the SO group were 1.12-fold and 4.21-fold higher than those in the normal group.ConclusionsMales were more likely to be sarcopenic and to have SO than females using the AWGS criteria. Females with SO were more likely to have higher blood glucose, whereas males with SO were more likely to have osteoporosis and dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria

Xiao-dong²,

Xie

et al. 2019

BMC Endocr Disord

125

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“…The metabolic pathways involved in sarcopenia and sarcopenic obesity are poorly understood. However, available scientific evidences support the role of inflammation on the process of sarcopenia, which seem to be mediated through alterations on glucose metabolism such as hyperglycaemia and insulin resistance . Insulin resistance often occurs with abdominal obesity, and the association between both conditions is influenced by an overproduction of inflammatory cytokines .…”

Section: Discussionmentioning

confidence: 99%

“…However, available scientific evidences support the role of inflammation on the process of sarcopenia, which seem to be mediated through alterations on glucose metabolism such as hyperglycaemia and insulin resistance. 8,41 Insulin resistance often occurs with abdominal obesity, and the association between both conditions is influenced by an overproduction of inflammatory cytokines. 42,43 Hyperglycaemia, insulin resistance, and excess cytokine production have been shown to impact sarcopenia by promoting the deterioration of skeletal muscle fibre diameter and protein content, as well as prompting metabolic breakdown of skeletal muscle encouraging sarcopenic process.…”

Section: Discussionmentioning

confidence: 99%

Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial

Abete

Konieczna

Zulet

et al. 2019

J cachexia sarcopenia muscle

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Background Sarcopenia is a progressive age‐related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods A cross‐sectional analysis based on baseline data from the PREDIMED‐Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex‐specific tertiles (T) of the sarcopenic index (SI) as assessed by dual‐energy X‐ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P‐trend < 0.05), PA (P‐trend < 0.0001), and the 30 s chair stand test (P‐trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P‐trend < 0.05), visceral fat and leucocyte count (all P‐trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil‐to‐lymphocyte ratio, and platelet count (all P‐trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance. Conclusions Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age‐related sarcopenia.

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“…Sarcopenia was defined as less than one SD below the mean of the sex‐specific SMI value for a young reference group (aged 18‐40 years) according to methods from previous studies on Korean populations 34‐36 . The cut‐off points for sarcopenia were 30.0% in men and 26.8% in women.…”

Section: Methodsmentioning

confidence: 99%

Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults

Yoo

Park

Jun

et al. 2020

Diabetes Metabolism Res

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BackgroundHeart failure with preserved ejection fraction is an emerging global health issue attributed to an ageing population. However, the association between low skeletal muscle mass, sarcopenic obesity, and left ventricular diastolic dysfunction remains unclear. In the current study, we aimed to investigate the relationship between low skeletal muscle mass, sarcopenic obesity, and diastolic dysfunction in a large cohort of Korean adults.MethodsWe conducted a cross‐sectional study of 31 258 subjects who underwent health examinations at Samsung Medical Centre's Health Promotion Centre in Seoul, Republic of Korea. Relative skeletal muscle mass was calculated using the skeletal muscle mass index [SMI (%) = appendicular skeletal muscle mass (kg)/body weight (kg) × 100], which was estimated by bioelectrical impedance analysis. Cardiac structure and function were evaluated by echocardiography.ResultsAmongst the 31 258 subjects, 3058 (9.78%) were determined to have diastolic dysfunction. The odds ratio (OR) of diastolic dysfunction was 1.56 [95% confidence interval (CI): 1.31‐1.85; p for trend <0.001] for the lowest SMI tertile relative to the highest SMI tertile following multivariable adjustment. Furthermore, the risk of diastolic dysfunction was much higher in the sarcopenic obesity (OR: 1.70, 95% CI: 1.44‐1.99), followed by in the obesity‐only (OR: 1.40, 95% CI: 1.21‐1.62), and sarcopenia‐only (OR: 1.32, 95% CI: 1.08‐1.61) when compared with the nonobese, nonsarcopenic group. These results remained consistent amongst the elderly (age ≥ 65 years).ConclusionsOur findings demonstrate that lower skeletal muscle mass and sarcopenic obesity are strongly associated with diastolic dysfunction in middle‐aged and older adults.

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Association between Sarcopenia, Sarcopenic Obesity, and Chronic Disease in Korean Elderly

Cited by 56 publications

References 17 publications

Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria

Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria

Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial

Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults

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