2022
DOI: 10.7326/m21-2973
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Association Between SARS-CoV-2 Messenger RNA Vaccines and Lower Infection Rates in Kidney Transplant Recipients

Abstract: The authors compared the rate of SARS-CoV-2 infection in kidney transplant recipients among those who did and did not receive a messenger RNA vaccine in the Czech Republic between February and May 2021 while the Alpha variant was predominant.

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Cited by 9 publications
(8 citation statements)
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“…With the rapid evolution of viral biology, treatment options and vaccination strategies, the assessment of vaccine effectiveness becomes ever more complicated. However, it has been previously reported by us and others that vaccines are effective in the reduction of infection rates in KTRs, although the effectiveness is lower than in the general population (28,29). Among the strengths of our study are the use of reliable epidemiologic data from the central nationwide registry with mandatory reporting (13), and the large cohort in a high-volume transplant center.…”
Section: Discussionmentioning
confidence: 97%
“…With the rapid evolution of viral biology, treatment options and vaccination strategies, the assessment of vaccine effectiveness becomes ever more complicated. However, it has been previously reported by us and others that vaccines are effective in the reduction of infection rates in KTRs, although the effectiveness is lower than in the general population (28,29). Among the strengths of our study are the use of reliable epidemiologic data from the central nationwide registry with mandatory reporting (13), and the large cohort in a high-volume transplant center.…”
Section: Discussionmentioning
confidence: 97%
“… 33–35 Therefore, the recommendation for booster vaccine doses for KTRs is of high importance, 36–38 especially since vaccination is associated with decreased risk of SARS-CoV-2 infection in KTRs. 39 …”
Section: Discussionmentioning
confidence: 99%
“…Among the different vaccines, though patients vaccinated with Ad26.COV2.S were observed to have lower seroconversion compared with BNT 162b2, a 6-month follow up revealed no difference in clinical outcomes [65]. Clinical outcomes in transplant recipients (pre-Omicron) have shown similar trends, with a lower risk of infections in vaccinated individuals [66 ▪ ,67,68 ▪ ].…”
Section: Clinical Outcomes and Vaccine Effectiveness In Kidney Diseasementioning
confidence: 96%