Association Between <scp><i>Staphylococcus aureus</i></scp> Bacteremia and Hospital Mortality in Hemodialysis Patients With Bloodstream Infection: A Multicenter Cohort From Japanese Tertiary Care Centers

Imaizumi, Tsutomu; Hasegawa, Takeshi; Nomura, Akihiro; Sasaki, Shin; Nishiwaki, Hiroki; Ozeki, Takaya; Shimizu, Hideaki; Minatoguchi, Shun; Yamakawa, Taishi; Yazawa, Masahiko; Uchida, Daisuke; Kawarazaki, Hiroo; Miyamoto, Masahito; Suzuki, Tomo; Koitabashi, Kenichiro; Furusho, Masahide; Fujita, Yoshiro

doi:10.1111/1744-9987.12534

Cited by 11 publications

(11 citation statements)

References 18 publications

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“…In another study, Streptococcus pneumoniae bacteremia had a large winter peak (peak-to-trough ratio, 3.42 [3.10-3.83]), Escherichia coli bacteremia had a small summer peak (1.17 [1.12-1.22]), and Staphylococcus aureus bacteremia had no seasonal variation (1.05 [1.00-1.13]) 3 . Because Staphylococcus aureus bacteremia has been a major cause of death from bloodstream infection in HD patients 20 , those previous studies are likely to be in line with our results. In patients with ESRD, the incidence of influenza-like illness has been highest in the winter 10 , which supports our findings that mortality from pneumonia infection had a winter peak.…”

Section: Discussionsupporting

confidence: 91%

Seasonal variations in cause-specific mortality and transition to renal replacement therapy among patients with end-stage renal disease

Goto

Hamano

Ogata

et al. 2020

Sci Rep

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Despite some studies showing seasonal variations in mortality and the transition to renal replacement therapy in patients with end-stage renal disease, detailed evidence is still scarce. We investigated seasonal variations in patients with end-stage renal disease using a large Japanese database for dialysis patients. We compared the fractions of all-cause and cause-specific mortality and the transition to renal replacement therapy among seasons and performed a mixed-effects Poisson regression analysis to compare the mortality among seasons after adjustment for some variables. The initiation of hemodialysis was highest in winter and lowest in summer. Seasonality in the initiation of peritoneal dialysis and transition to kidney transplantation differed from hemodialysis. All-cause mortality was highest in the winter and lowest in the summer. Death from coronary artery disease, heart failure, cerebral hemorrhage, and infectious pneumonia had similar seasonality, but death from cerebral infarction, septicemia, or malignant tumor did not have similar seasonality. In conclusion, the initiation of hemodialysis, all-cause mortality, and mortality from coronary heart disease, heart failure, cerebral hemorrhage, and infectious pneumonia were significantly highest in winter and lowest in summer. However, the initiation of peritoneal dialysis, transition to kidney transplantation, or mortality from cerebral infarction, septicemia, or malignant tumor did not have similar seasonal variations.

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Section: Discussionsupporting

confidence: 91%

Seasonal variations in cause-specific mortality and transition to renal replacement therapy among patients with end-stage renal disease

Goto

Hamano

Ogata

et al. 2020

Sci Rep

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“…A total of 72 S. aureus isolates were cultured from patients undergoing HD, and among these, 43.1% were MRSA and 56.9% were methicillin sensitive S. aureus (MSSA). Previous studies have highlighted a high percentage of S. aureus colonization among HD patients 17,23,24 . The percentage of MRSA and MSSA in our study was found similar to that of a study published from Japan 17 .…”

Section: Resultsmentioning

confidence: 98%

“…Previous studies have highlighted a high percentage of S. aureus colonization among HD patients 17,23,24 . The percentage of MRSA and MSSA in our study was found similar to that of a study published from Japan 17 . The antibiotic profiling of S. aureus is very critical in management of the serious infections among the hospitalised patients.…”

Section: Resultsmentioning

confidence: 98%

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Molecular Characterization of Staphylococcus aureus Isolated from Renal Hemodialysis (HD) Patients from Saudi Arabia

Al-Mogbel¹,

Al-Rashid²,

Meqdam³

et al. 2019

J Pure Appl Microbiol

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Staphylococcus aureus, including methicillin resistant S. aureus (MRSA) is the most commonly isolated pathogen in hospitals worldwide. The aim of present study was molecular characterization of Staphylococcus aureus isolated from renal hemodialysis (HD) patients from Ha'il region of Saudi Arabia. A total of 392 samples were screened from 204 HD patients for colonization of S. aureus. The isolated bacteria were identified by MALDI-TOF-MS. Antibiotic susceptibility testing was performed using Microscan. Among these isolates, 72 S. aureus (43% MRSA and 57% MSSA) were identified.The isolates were considerably resistant with varied profile to the antibiotics tested except being 100% susceptible to vancomycin, linezolid and teicoplanin. Of the isolates, 22.2% were positive for biofilm assay. Four representative MRSA isolates were selected and whole genome sequence analysis was performed using MiSeq. Two out of the 4 MRSA were found to be ST-1 and 2 were found to be ST-32. Among MRSA isolates, 25.8% were negative for mecA and all of them were negative for mecC gene. A high prevalence of MRSA in HD patients as well as high percentage of biofilm production in MRSA isolates highlights the vital role for standardized surveillance along with validated molecular typing methods to evaluate the incidence of MRSA and accordingly to control its spread.

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“…Outside Europe, reported mortality rates are higher, ranging from 20% (12-week mortality) after S aureus bacteremia in the United States 16 to 46.9% (in-hospital mortality) in Japan. 35 Thus, short-term mortality is lower in HD patients, especially those cannulating with the buttonhole technique, compared with population controls. This might be explained because the threshold for hospital admission and blood culturing of dialysis patients showing signs and symptoms compatible with S aureus bacteremia may be lower in a hospital setting than in the general population.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus Bacteremia Risk in Hemodialysis Patients Using the Buttonhole Cannulation Technique: A Prospective Multicenter Study

et al. 2019

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Arteriovenous fistulas are the preferred access type for hemodialysis. The buttonhole needling technique has become an alternative to stepladder or area puncture. However, an increased risk for infection has been described. The present study examined the risk for infectious complications with different needling techniques. Study Design: Prospective multicenter observational cohort study with 5 years of follow-up. Setting & Participants: In-center hemodialysis patients from 5 hemodialysis units in Denmark, dialyzed on a native arteriovenous fistula. 286 patients were included; 144 cannulated with the buttonhole technique. Exposure: The buttonhole cannulation technique was compared to the stepladder or area puncture technique. Outcomes: Primary end points: event rates of access-related Staphylococcus aureus bacteremia and the HR for first access-related S aureus bacteremia. Secondary end points: local infections and access-related S aureus bacteremia-related metastatic infections and mortality. Analytical Approach: Time-to-event analysis using Cox proportional hazards regression to estimate the HR of access-related S aureus bacteremia in buttonhole cannulation compared to stepladder/ area puncture. Poisson regression was used for incidence rate ratio calculations. Results: S aureus caused 48 access-related bacteremias; 43 (90%) in the buttonhole group compared with 5 (10%) in the stepladder/area group. The HR for first access-related S aureus bacteremia was significantly higher for buttonhole cannulation compared to stepladder/area needling (unadjusted, 6.8 [95% CI, 2.4-19.1]; adjusted, 8.4 [95% CI, 2.9-24.2]). The incidence rate ratio for access-related S aureus bacteremia was 6.8 (95% CI, 2.9-16.1), and the incidence rate ratio of local cannulation-site infection without access-related S aureus bacteremia was 3.8 (95% CI, 1.3-15.4) for buttonhole cannulation compared to stepladder/area needling. Limitations: Nonrandomized observational design, prevalent hemodialysis patients. Conclusions: Access-related S aureus bacteremia rates were very high for buttonhole cannulation compared to stepladder/area needling, questioning the use of buttonhole cannulation in routine clinical practice. A restrictive approach to buttonhole use is recommended, with buttonhole cannulation only being used as a second alternative to area technique when stepladder cannulation is not feasible. Complete author and article information provided before references.

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Association Between Staphylococcus aureus Bacteremia and Hospital Mortality in Hemodialysis Patients With Bloodstream Infection: A Multicenter Cohort From Japanese Tertiary Care Centers

Cited by 11 publications

References 18 publications

Seasonal variations in cause-specific mortality and transition to renal replacement therapy among patients with end-stage renal disease

Seasonal variations in cause-specific mortality and transition to renal replacement therapy among patients with end-stage renal disease

Molecular Characterization of Staphylococcus aureus Isolated from Renal Hemodialysis (HD) Patients from Saudi Arabia

Staphylococcus aureus Bacteremia Risk in Hemodialysis Patients Using the Buttonhole Cannulation Technique: A Prospective Multicenter Study

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