Association between seasonal serum folate levels and ultraviolet radiation

Valencia-Vera, Estefanía; Aguilera, José; Cobos, Andrés; Bernabó, Jean-Luc; Pérez-Valero, Vidal; Herrera‐Ceballos, Enrique

doi:10.1016/j.jphotobiol.2018.10.012

Cited by 9 publications

(2 citation statements)

References 27 publications

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“…In particular, we considered a possible role of MAIT cells in atopic dermatitis (AD; eczema), a common chronic skin disease associated with highly pruritic lesions, loss of skin barrier function and increased host-bacterial crosstalk. 20 Intriguingly, exposure to ultraviolet light, from sunlight or in the context of phototherapy (a second-line treatment for AD 20 ), is known to degrade folate in the skin to 6-formylpterin (6-FP), 21,22 which is a reported antagonist of MAIT cells. 9,23 However, the physiological effects of this bioactive photometabolite have not yet been addressed.…”

Section: Introductionmentioning

confidence: 99%

MR1‐dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Naidoo

Woods

Pellefigues

et al. 2021

Allergy

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Background: Mucosal-associated invariant T (MAIT) cells are unconventional T cells which recognize microbial metabolites presented by the major histocompatibility complex class I-related molecule MR1. Although MAIT cells have been shown to reside in human and murine skin, their contribution to atopic dermatitis (AD), an inflammatory skin disease associated with barrier dysfunction and microbial translocation,has not yet been determined.Methods: Genetic deletion of MR1 and topical treatment with inhibitory MR1 ligands, which result in the absence and functional inhibition of MAIT cells, respectively, were used to investigate the role of MR1-dependent immune surveillance in a MC903driven murine model of AD. Results:The absence or inhibition of MR1 arrested AD disease progression through the blockade of both eosinophil activation and recruitment of IL-4-and IL-13producing cells. In addition, the therapeutic efficacy of phototherapy against MC903driven AD could be increased with prior application of folate, which photodegrades into the inhibitory MR1 ligand 6-formylpterin. Conclusion:We identified MAIT cells as sentinels and mediators of cutaneous type 2 immunity. Their pathogenic activity can be inhibited by topical application or endogenous generation, via phototherapy, of inhibitory MR1 ligands.

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Section: Introductionmentioning

confidence: 99%

MR1‐dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Naidoo

Woods

Pellefigues

et al. 2021

Allergy

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“…Folic acid plays a key role in neurodevelopment, 4 and circulating folate concentrations are at their lowest during the summer and their highest during winter, a phenomenon attributed to photodegradation of folic acid in human skin by ultraviolet radiation. 5 Taken together, these observations raise the hypothesis that seasonal variation in folate levels may influence neurodevelopment.…”

Section: Strengths Of Our Study Include Its Large Sample Size and Itsmentioning

confidence: 89%

Seasonal variation in fetal lateral cerebral ventricular diameter

et al. 2019

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Photobiology

Young

2024

Rook's Textbook of Dermatology

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Solar ultraviolet radiation (UVR) is ubiquitous and has many molecular, cellular and clinical effects on healthy human skin. These effects can affect the skin directly and/or have systemic consequences and are heavily dependent on constitutive skin pigmentation. This chapter provides an overview of solar UVR and its effects on skin, as well as their mitigation, and provides a background for the understanding of phototherapy and the photodermatoses that are discussed in other chapters. Dermatologists have largely focused on the adverse effects of sunlight but there is increasing interest in clinical benefits other than vitamin D synthesis.

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Association between seasonal serum folate levels and ultraviolet radiation

Cited by 9 publications

References 27 publications

MR1‐dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

MR1‐dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Seasonal variation in fetal lateral cerebral ventricular diameter

Photobiology

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