Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey

Li, Xiuzhu; Fan, Yun; Zhang, Yan; Huang, Xiaomin; Huang, Zhenyao; Yu, Mingming; Xu, Qiaoqiao; Han, Xiumei; Lu, Chuncheng; Wang, Xinru

doi:10.1007/s11356-020-10906-w

Cited by 5 publications

(13 citation statements)

References 59 publications

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“…Blood eosinophils play a crucial role in the occurrence, progression, and treatment of asthma [ 43 , 44 , 45 , 46 , 47 ]. However, according to previous studies, the results investigating the correlation between metal elements and the occurrence and progression of asthma were inconsistent [ 31 , 48 , 49 ]. Meanwhile, the studies on the impact of metal elements on blood eosinophil counts among adults with asthma are few.…”

Section: Discussionmentioning

confidence: 99%

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

Wen

Giri

et al. 2023

JCM

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(1) Background: Heavy metals are widely used and dispersed in the environment and people’s daily routines. Many studies have reported an association between heavy metal exposure and asthma. Blood eosinophils play a crucial role in the occurrence, progression, and treatment of asthma. However, there have thus far been few studies that aimed to explore the effects of heavy metal exposure on blood eosinophil counts in adults with asthma. Our study aims to discuss the association between metal exposure and blood eosinophil counts among asthmatic adults. (2) Methods: A total of 2026 asthmatic individuals were involved in our research from NHANES with metal exposure, blood eosinophils, and other covariates among the American population. A regression model, the XGBoost algorithm, and a generalized linear model (GAM) were used to explore the potential correlation. Furthermore, we conducted a stratified analysis to determine high-risk populations. (3) Results: The multivariate regression analysis indicated that concentrations of blood Pb (log per 1 mg/L; coefficient β, 25.39; p = 0.010) were positively associated with blood eosinophil counts. However, the associations between blood cadmium, mercury, selenium, manganese, and blood eosinophil counts were not statistically significant. We used stratified analysis to determine the high-risk group regarding Pb exposure. Pb was identified as the most vital variable influencing blood eosinophils through the XGBoost algorithm. We also used GAM to observe the linear relationship between the blood Pb concentrations and blood eosinophil counts. (4) Conclusions: The study demonstrated that blood Pb was positively correlated with blood eosinophil counts among asthmatic adults. We suggested that long-time Pb exposure as a risk factor might be correlated with the immune system disorder of asthmatic adults and affect the development, exacerbation, and treatment of asthma.

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Section: Discussionmentioning

confidence: 99%

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

Wen

Giri

et al. 2023

JCM

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“…A case-control study in a Chinese adult population (sample size 1:1 matched, 551 patients in both the asthma group and the control group) as well as an analysis considering 1857 American adults in the NHANES 2007-2008 survey suggested that the prevalence of asthma was positively correlated with the level of U in the urine [7] , [8,9]. Since then, this conclusion has been con rmed by Li, X et al, who obtained consistent results after considering 3425 American adults aged 20-59 (2011-2014) [8,9]. In this study, a sample size of 13,581 of American general population was considered as the study population (NHANES 2007-2016), and their age was ≥6 years old, which basically represents the general population in the United States.…”

Section: Discussionmentioning

confidence: 99%

“…The following covariates that can be considered as potential confounders associated with urine U and asthma prevalence were collected according to previous studies [7,8] and clinical considerations: age, gender, race, BMI, poverty to income ratio (PIR), education level, marital status, blood sugar (diabetes), blood pressure (hypertension), liver diseases, smoking, and alcohol consumption. The following blood parameters were also collected: total protein (TP), albumin, globulin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), serum creatinine (Scr), total bilirubin (TB), serum uric acid (SUA), and the content of the following metals in the urine were also collected: barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), Pb, stibium (Sb), thallium (Tl), tungsten (Tu), and Hg.…”

Section: Covariatesmentioning

confidence: 99%

“…Indeed, an association between uranium (U) and asthma prevalence in adults was found in China and U.S. [7][8][9]. Exposure to harmful heavy metals such as lead (Pb), mercury (Hg) and arsenic (As) can cause a series of human diseases [10,11], and among them, also U poisoning can cause serious health problems such as respiratory diseases and lung cancer [7][8][9][10]12], renal toxicity [13], as well as reproductive system toxicity [14] and immune system damage [15]. The sources of U pollution include mining, military activities, nuclear facilities, groundwater, and phosphate fertilizers [16].…”

Section: Introductionmentioning

confidence: 99%

“…The sources of U pollution include mining, military activities, nuclear facilities, groundwater, and phosphate fertilizers [16]. At present, few studies reported the association between U exposure and the prevalence of asthma in adults [7][8][9], and the epidemiological association between U and asthma prevalence in the general population is not well known. In view of the enormous harm of asthma to human health and the economic burden, a large sample of epidemiological data on the impact of the environmental factors on asthma is necessary to carry out the primary prevention of asthma.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Urine Uranium and Asthma Prevalence: NHANES 2007-2016

Huang

Wang

2021

Preprint

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Background: Previous studies showed that urine uranium (U) is associated with asthma prevalence in adults. However, the association between them among the general population is unclear. Therefore, this study aimed at exploring this unclear association. Methods: The data of the participants were collected from the 2007-2016 National Health and Nutrition Examination Survey (NHANES) performed in the United States. Continuous variables with skewed distribution were analyzed using Ln-transformation. The association between urine U and asthma prevalence was analyzed by multiple regression analysis, and the linear association between them was evaluated by the smooth curve fitting. The subgroup analysis was performed by the hierarchical multivariate regression analysis.Results: A total of 13,581 participants were included in our analysis. The multivariate regression analysis showed that LnU was independently and positively correlated with asthma prevalence in the general population (OR=1.12; 95% CI:1.04,1.20; P=0.002). The subgroup analysis revealed that the College Graduate or above showed the stronger association between LnU and asthma prevalence (<9th Grade: OR=0.84; 95% CI: 0.61, 1.14; 9-11th Grade: OR=1.23; 95% CI: 0.99,1.52; High School Grade: OR=1.00; 95% CI: 0.84, 1.19; College: OR=1.04; 95% CI: 0.91,1.19; ≥College Graduate: OR=1.32; 95% CI: 1.11, 1.57; P for interaction=0.0389). Conclusions: Our research suggested that urinary U levels are positively correlated with asthma prevalence in the general population of the United States, and the association is especially strong among people with high level of education.

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Health threat of PM2.5-bound trace elements exposure on asthma hospital admission: A time-stratified case-crossover study

Wang

Zheng

et al. 2022

Environment International

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Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey

Cited by 5 publications

References 59 publications

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

Association Between Urine Uranium and Asthma Prevalence: NHANES 2007-2016

Health threat of PM2.5-bound trace elements exposure on asthma hospital admission: A time-stratified case-crossover study

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