Association Between Selenium and Circulating Adipokine Levels in Patients with Polycystic Ovary Syndrome

Abstract

Growing evidence has shown a possible correlation between selenium (Se) and its main transport protein, selenoprotein-P (SePP), with polycystic ovary syndrome (PCOS). The Se and SePP link with adipokine levels in this group of individuals received insu cient attention, though. In the present study, we aimed to investigate the associations of Se and SePP with adipokine levels in patients with PCOS. In this crosssectional study, 115 patients with PCOS aged 18-45 years, diagnosed based on Rotterdam Consensus criteria, were recruited. Participants' general characteristics were collected using a general questionnaire and anthropometric measurements were taken. The blood sample was obtained, and serum levels of leptin, adiponectin, visfatin, resistin, and omentin-1, as well as glucose metabolism markers, were measured. Serum levels of Se and SePP were inversely correlated with fasting Blood Sugar (FBS), serum insulin, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). In addition, serum levels of Se and SePP positively correlated with adiponectin and visfatin serum levels. Although there was no signi cant correlation between serum Se and serum omentin-1 levels, a signi cant positive correlation was found between the serum levels of SePP and this adipokine. The present study found that serum Se and SePP levels were positively correlated with serum adiponectin and visfatin levels. Further studies are required to con rm these ndings.