Association between selenium, cadmium, and arsenic levels and genetic polymorphisms in DNA repair genes (XRCC5, XRCC6) in gastric cancerous and non-cancerous tissue

Safarzad, Mahdieh; Besharat, Sima; Salimi, Saeedeh; Azarhoush, R; Behnampour, Nasser; Joshaghani, Hamidreza

doi:10.1016/j.jtemb.2019.06.003

Cited by 13 publications

(6 citation statements)

References 63 publications

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“…XRCC5, also called Ku80, forms a heterodimer with XRCC6 to bind the ends of broken DNA double strands. The heterodimer is also considered as participating in migration and invasion of tumors, not just maintaining the stability of chromosomes [34]. Recently, XRCC5 has been reported to be highly expressed in various tumors such as gastric cancer, breast cancer and hepatocellular carcinoma [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway

Wang¹,

Huang²,

Liu³

et al. 2021

J. Cancer

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Section: Discussionmentioning

confidence: 99%

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway

Wang¹,

Huang²,

Liu³

et al. 2021

J. Cancer

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“…361−364 For example, remarkably higher selenium concentrations were observed in gastric cancer tissues than in normal gastric mucosal tissues. 365 Similarly, potassium abnormality is associated with gastric cancer and other intestinal adenocarcinomas, and a high potassium level in tumor tissues is related to lymphatic duct metastasis. 366 Notably, as a cofactor for more than 300 enzymes, magnesium is significantly elevated in GBM.…”

Section: Biochemical and Molecular Abnormalitymentioning

confidence: 99%

“…Apart from iron, copper, and zinc, the concentrations of some other elements, such as calcium, potassium, cadmium, nickel, rubidium, selenium, magnesium, and manganese, also differ between cancer tissues and the related normal tissues. − For example, remarkably higher selenium concentrations were observed in gastric cancer tissues than in normal gastric mucosal tissues . Similarly, potassium abnormality is associated with gastric cancer and other intestinal adenocarcinomas, and a high potassium level in tumor tissues is related to lymphatic duct metastasis .…”

Section: Abnormalities In Tumormentioning

confidence: 99%

Tumor Abnormality-Oriented Nanomedicine Design

Zhou,

Xiang,

Qiu

et al. 2023

Chem. Rev.

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Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic efficacy. Nanomedicines responsive to the pathological abnormalities in the tumor microenvironment (TME) are expected to overcome the biological limitations of conventional nanomedicines, enhance the therapeutic efficacies, and further reduce the side effects. This Review aims to quantitate the various pathological abnormalities in the TME, which may serve as unique endogenous stimuli for the design of stimuli-responsive nanomedicines, and to provide a broad and objective perspective on the current understanding of stimuli-responsive nanomedicines for cancer treatment. We dissect the typical transport process and barriers of cancer drug delivery, highlight the key design principles of stimuli-responsive nanomedicines designed to tackle the series of barriers in the typical drug delivery process, and discuss the “all-into-one” and “one-for-all” strategies for integrating the needed properties for nanomedicines. Ultimately, we provide insight into the challenges and future perspectives toward the clinical translation of stimuli-responsive nanomedicines.

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“…A recently conducted Cochrane review found no evidence that increasing Se intake through diet or supplementation prevented cancer in humans [ 16 ]. It is thought that incremental doses of Se would be beneficial against cancer [ 17 ], but a study evaluating tissue accumulation of Se showed that levels were higher in gastric cancer tissues than non-cancerous ones [ 18 ]. With this work on the influence of Se on carcinogenesis, it remains unclear what Se levels would be most beneficial for cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the association between gastric cancer and plasma selenium in Zambian adults: a case–control study

Zyambo¹,

Kelly²,

Kayamba³

2022

ecancer

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There is some evidence that Selenium (Se) is protective against gastric carcinogenesis, but these data are inconsistent. With a predicted increase in gastric cancer cases in Africa over the next 20 years, there is an urgent need to identify strategies that could be employed to prevent the surge. The objective of our study was to investigate the association between gastric cancer and plasma Se levels in Zambian adults. Our method used a case-control study with cases having either confirmed gastric cancer or premalignancies and controls having none. In addition, we measured antibodies against Helicobacter pylori and human immunodeficiency virus. Data were analysed with Stata 15 software using standard statistical methods. Using a normal reference range for Se of 0.9-1.9 µmol/L, 140/159 (88%) study participants had Se deficiency. Plasma Se levels were similar in all the three groups; 0.33 (interquartile range (IQR) 0.14-0.64) µmol/L for patients with gastric cancer, 0.38 (IQR 0.21-0.60) µmol/L for premalignant lesions and 0.28 (IQR 0.14-0.64) µmol/L in controls, (p-values = 0.35 and 0.34, respectively). In conclusion, we found no association between plasma Se levels and gastric cancer or premalignant lesions among adult Zambian adults.

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Association between selenium, cadmium, and arsenic levels and genetic polymorphisms in DNA repair genes (XRCC5, XRCC6) in gastric cancerous and non-cancerous tissue

Cited by 13 publications

References 63 publications

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway

Tumor Abnormality-Oriented Nanomedicine Design

Evaluation of the association between gastric cancer and plasma selenium in Zambian adults: a case–control study

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