Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study

Duda-Sobczak, Anna; Falkowski, Bogusz; Araszkiewicz, Aleksandra; Zozulińska−Ziółkiewicz, Dorota

doi:10.1016/j.clinthera.2018.02.016

Cited by 18 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The skin concentrations of AGEs have been related to coronary calcifications, left ventricular masses and progression of intima-media thickness in the DCCT-EDIC study [ 11 ]. SAF was related to the age of the participants (ß = + 0.397; p < 0.001) which is very similar to reports from other groups in participants with T1D [ 26 – 28 ]. Although an indirect estimation of the accumulation of AGEs, SAF has some advantages on skin biopsies: low cost, simplicity, non-invasiveness, and repeatability.…”

Section: Discussionsupporting

confidence: 83%

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Blanc-Bisson

Vélayoudom-Céphise

Cougnard‐Grégoire

et al. 2018

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundAdvanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searched for an association between SAF and major adverse cardiovascular events (MACE) incidence in subjects with Type 1 Diabetes (T1D) during a 7 year follow-up.MethodsDuring year 2009, 232 subjects with T1D were included. SAF measurement, clinical [age, sex, body mass index (BMI), comorbidities] and biological data (HbA1C, blood lipids, renal parameters) were recorded. MACE (myocardial infarction, stroke, lower extremity amputation or a revascularization procedure) were registered at visits in the center or by phone call to general practitioners until 2016.ResultsThe participants were mainly men (59.5%), 51.5 ± 16.7 years old, with BMI 25.0 ± 4.1 kg/m2, diabetes duration 21.5 ± 13.6 years, HbA1C 7.6 ± 1.1%. LDL cholesterol was 1.04 ± 0.29 g/L, estimated Glomerular Filtration Rates (CKD-EPI): 86.3 ± 26.6 ml/min/1.73 m2. Among these subjects, 25.1% were smokers, 45.3% had arterial hypertension, 15.9% had elevated AER (≥ 30 mg/24 h), and 9.9% subjects had a history of previous MACE. From 2009 to 2016, 22 patients had at least one new MACE: 6 myocardial infarctions, 1 lower limb amputation, 15 revascularization procedures. Their SAF was 2.63 ± 0.73 arbitrary units (AU) vs 2.08 ± 0.54 for other patients (p = 0.002). Using Cox-model, after adjustment for age (as the scale time), sex, diabetes duration, BMI, hypertension, smoking status, albumin excretion rates, statin treatment and a previous history of MACE, higher baseline levels of SAF were significantly associated with an increased risk of MACE during follow-up (HR = 4.13 [1.30–13.07]; p = 0.02 for 1 AU of SAF) and Kaplan–Meier curve follow-up showed significantly more frequent MACE in group with SAF upper the median (p = 0.001).ConclusionA high SAF predicts MACE in patients with T1D.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0718-8) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionsupporting

confidence: 83%

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Blanc-Bisson

Vélayoudom-Céphise

Cougnard‐Grégoire

et al. 2018

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…In fact, it was reported that the modification of the collagen such as advanced glycation end products (AGEs) contributed to the relationship between habitual physical activity and skin mechanical properties. Higher habitual physical activity was related to lower accumulation of AGEs in the skin of patients with type 1 diabetes using an AGE reader 9 . The autofluorescence measured using the AGE reader was positively correlated with the content of AGEs in the collagen of the skin 22 .…”

Section: Discussionmentioning

confidence: 89%

“…Regular moderate physical activity protected against oxidative damage, whereas endurance exercise with a lack of training mediated oxidative stress 8 . Higher habitual physical activity was related to lower accumulation of advanced glycation end products (AGEs) in patients with type 1 diabetes 9 . In addition, there are some reports regarding the relationship among physical activity skin structure and skin components 10 11 .…”

Section: | Introductionmentioning

confidence: 99%

The relationship between habitual physical activity and skin mechanical properties

Nakagawa

Shimizu

Sugawara

et al. 2020

Skin Research and Technology

View full text Add to dashboard Cite

Background Physical activity (PA) is important for body health. A few reports suggested that PA also influenced skin structure and components. Little data are available on the influence of PA on skin mechanical properties (SMP). Here, we investigated the relationship between PA and SMP. Methods Twenty‐five healthy Japanese female subjects (31.0 ± 3.3 years) were enrolled in the study. To monitor the 24‐hr pulse rate, a wrist watch‐type pulse monitor was used. PA intensity was divided into five PA intensity zones (max, anaerobic, aerobic, fat combustion, and warm‐up) by the pulse monitor. The average values of the time spent on each intensity for 70 days were calculated. To measure SMP, a Cutometer was used at the end of the monitoring. R0 indicated the height of the maximal skin deformation, and R6 was the ratio between viscoelastic and elastic deformation. Results R0 was positively correlated with the time spent in four of the five PA intensity zones (max, anaerobic, aerobic, and fat combustion), whereas R6 was negatively correlated with the time spent in these four PA intensity zones. The time of warm‐up did not correlate with SMP. Conclusion These results suggest that habitual moderate‐to‐vigorous PA influences SMP.

show abstract

“…In a second paper, Duda-Sobczak examines the potential for skin autofluorescence as a marker of tissue accumulation of advanced glycation end-products in adults with type 1 diabetes, to serve as a marker for physical activity among patients with type 1 diabetes. 11 Gastroparesis has been recognized as being associated with type 1 diabetes for many years but has only recently been shown to be fairly common among patients with type 2 diabetes. 12 Gastroparesis is defined as "a chronic symptomatic disorder of the stomach characterized by delayed emptying without evidence of mechanical obstruction."…”

Section: Emerging Diabetes Research From Early Investigatorsmentioning

confidence: 99%

Emerging Diabetes Research From Early Investigators

Ryan

2018

Clinical Therapeutics

View full text Add to dashboard Cite

Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study

Abstract: Higher physical activity is related to lower accumulation of AGEs in patients with T1D. Our study provides new insight into the beneficial effects of physical activity in T1D according to tissue accumulation of AGEs.

Cited by 18 publications

References 27 publications

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

The relationship between habitual physical activity and skin mechanical properties

Emerging Diabetes Research From Early Investigators

Contact Info

Product

Resources

About