Association between Serum Adipocyte Fatty Acid Binding Protein Level and Endothelial Dysfunction in Chronic Hemodialysis Patients

Abstract

Adipocyte fatty acid binding protein (A-FABP) is associated with atherosclerosis, and endothelial dysfunction is one of the reasons for adverse cardiovascular outcomes in patients undergoing hemodialysis (HD). This study investigated the correlation between serum A-FABP levels and endothelial function in HD patients. Fasting blood samples were collected from 90 HD patients. A-FABP levels were measured using a commercial enzyme immunoassay kit. Endothelial function was evaluated by a digital thermal monitoring test to measure vascular reactivity index (VRI). VRI < 1.0, 1.0 ≤ VRI < 2.0, and VRI ≥ 2.0 indicated poor, intermediate, and good vascular reactivity, respectively. In total, 14 (15.6%), 38 (42.2%), and 38 (42.2%) HD patients had poor, intermediate, and good VRI, respectively. Patients with poor VRI had lower pre-HD and post-HD body weight, body mass index, and serum creatinine level but higher serum A-FABP level (p = 0.001) than those with intermediate and good VRI. Log-transformed VRI (log-VRI) positively correlated with serum creatinine and negatively correlated with A-FABP by multivariate linear regression analysis. We concluded that A-FABP correlated with endothelial dysfunction in chronic HD patients.

Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of Pinolenic Acid against Atherosclerosis

“…Sclareol can also induce apoptosis through the activation of mitochondrial and death receptor pathways [51]. Creatinine levels positively correlate with endothelial function [52]. Decreased production of succinic acid semialdehyde may lead to low levels of succinate, further contributing to the dysfunction of the tricarboxylic acid cycle [53].…”

Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis

“…The body mass index (BMI) was determined by measuring the square height (m 2 ) and body weight (kg) followed hemodialysis. [15]. Before initiating hemodialysis, each patient had a blood sample of about 5 milliliters obtained.…”

“…The vascular reactivity index (VRI) was calculated using methods that had been previously published. [15,18,19]. The patients' VRI was categorized as poor (0 to <1.0), intermediate (1.0 to <2.0), or good (≥2.0).…”