Association between serum anti-Müllerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome

Abstract

ObjectiveTo evaluate the correlation between serum levels of anti-Müllerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS).MethodsSeventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (≥14 mm) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated.ResultsOvarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively).ConclusionOvarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.

Genetic Polymorphism ofCYP2D6and Clomiphene Concentrations in Infertile Patients with Ovulatory Dysfunction Treated with Clomiphene Citrate

“…This effect may compromise the outcome of CC ovulation induction. Previous studies reported that PCOS women with high circulating AMH seem to be resistant to CC and may require a higher starting dose ( 15 , 16 ). To evaluate prospectively the prognostic factors for ovulatory responses following CC administration in PCOS, endocrine and metabolic parameters between responder and non-responder groups were analyzed in the previous study ( 17 ).…”

IVF Outcome With High Level of AMH: Focus on Pcos Versus Non-pcos

“…Cleavage embryos were assessed on day 2 (44-46 h after insemination or sperm injection) and day 3 (66-72 h insemination or sperm injection). Embryos were graded based on the criteria described by Veeck [19]. Embryo transfers were performed with Wallace catheters (Smiths Medical, OH, USA) at approximately 1 cm less than the uterine depth identi ed at prior trial transfer.…”

Anti-Mullerian hormone and response to ovulation induction with clomiphene citrate in women with polycystic ovary syndrome

“…13 Others found AMH to be of limited value in the prediction of PCOS response to ovulation induction with CC. 25,26 However, many other studies using other protocols for induction of ovulation in PCOS. 12,20,27 have found AMH to be a very useful predictor of poor responder PCOS and even to be to be the most significant independent predictor for the FSH dosage needed to reach mono-follicular development for ovulation.…”