Association Between Serum C-Peptide Level and Cardiovascular
                    Autonomic Neuropathy According to Estimated Glomerular Filtration Rate in
                    Individuals with Type 2 Diabetes

Chung, Jin Ook; Park, Seon-Young; Cho, Dong Hyeok; Chung, Dong Jin; Chung, Min Young

doi:10.1055/a-1017-3048

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…The effect of C-peptide in type 2 diabetic patients is controversial and more complicated. Serum C-peptide levels were reported to be inversely associated with the prevalence of diabetic retinopathy and cardiovascular autonomic neuropathy in patients with T2DM [ 29 , 30 ]. Low C-peptide level was associated with increased cardiovascular risk in T2DM [ 31 ], even if glucose variation or severe hypoglycemia was considered [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study

Yan

Sun

et al. 2022

Cardiovasc Diabetol

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Background Recent literature reported the biological role of C-peptide, but this role is still controversial and unclear. The primary aim of this study was to investigate associations between C-peptide and cardiovascular biomarkers as well as events. Methods A total of 55636 participants who had a health examination from 2017 to 2021 were included. Of them, 6727 participants visited the hospital at least twice. Cardiovascular biomarkers like high-sensitivity C-reactive protein (hs-CRP) and high-sensitivity cardiac troponin T (hs-cTnT) were measured and their relationships with fasting C-peptide were evaluated for all participants. Cardiovascular events were obtained during the last visit and their associations with C-peptide were evaluated for those participants who visited the hospital at least twice. Results Among the included participants, 11.1% had a previous type 2 diabetes mellitus (T2DM). In the participants without previous T2DM, the relationships between fasting C-peptide and hs-CRP and hs-cTnT were negative if the value of fasting C-peptide was < 1.4 ng/mL and positive if the value was ≥ 1.4 ng/mL. These relationships remained significant after adjusting for hemoglobin A1c, insulin resistance index, and its interaction with C-peptide, even if the participants were stratified by glucose metabolism status or levels of insulin resistance index. Hazard ratios of cardiovascular events were first decreased and then increased with the increasing of baseline C-peptide levels, though these associations became unsignificant using the multivariate Cox regression model. Unlike the participants without previous T2DM, the associations of C-peptide with cardiovascular biomarkers and events were not significant in the patients with previous T2DM. Conclusions The associations of C-peptide with cardiovascular biomarkers and events were different between the participants without previous T2DM and those with previous T2DM. The effect of C-peptide on cardiovascular risk may be bidirectional, play a benefit role at a low level, and play a harmful role at a high level in the nondiabetic adults and the patients with newly diagnosed T2DM.

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Section: Discussionmentioning

confidence: 99%

The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study

Yan

Sun

et al. 2022

Cardiovasc Diabetol

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“…In this study, a higher level of fasting C-peptide was negatively associated with DPN, which was consistent with a previous study indicating that the C-peptide level was negatively associated with cardiovascular autonomic neuropathy in individuals with T2DM. 48 But a study in Denmark revealed that C-peptide ≥1550 pmol/L was associated with DPN. 49 It was also reported that C-peptide improved neuropathy in type 1 diabetic BB/Wor-rats.…”

Section: Author Contributionsmentioning

confidence: 99%

Prevalence and risk factors of diabetic peripheral neuropathy: A population‐based cross‐sectional study in China

Wang,

Ji,

Ran

et al. 2023

Diabetes Metabolism Res

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AimsTo assess the prevalence of diabetic peripheral neuropathy (DPN) and its risk factors in the type 2 diabetes mellitus (T2DM) population.MethodsThis cross‐sectional study enroled patients with T2DM between July and December 2017 from 24 provinces in China. Diabetic peripheral neuropathy and its severity were assessed by the Toronto clinical scoring system, neuropathy symptoms score (NSS) and neuropathy disability score. The prevalence of DPN and its risk factors were analysed.ResultsA total of 14,908 patients with T2DM were enroled. The prevalence of DPN was 67.6%. Among 10,084 patients with DPN, 4808 (47.7%), 3325 (33.0%), and 1951 (19.3%) had mild, moderate, and severe DPN, respectively. The prevalence of DPN in females was higher than in males (69.0% vs. 66.6%, P = 0.002). The prevalence of DPN increased with age and course of diabetes and decreased with body mass index (BMI) and education level (all P for trend <0.05). The comorbidities and complications in patients with DPN were higher than in those without DPN, including hypertension, myocardial infarction, diabetic retinopathy, and diabetic nephropathy (all P < 0.001). Age, hypertension, duration of diabetes, diabetic retinopathy, diabetic nephropathy, glycated haemoglobin, high‐density lipoprotein cholesterol, and lower estimated glomerular filtration rate were positively associated with DPN, while BMI, education level, fasting C‐peptide, and uric acid were negatively associated with DPN.ConclusionsAmong patients with T2DM in China, the prevalence of DPN is high, especially in the elderly, low‐income, and undereducated patients.

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“…The data storage system on which it was established integrated obese and lean individuals with normalized T2D and glycemic metabolism, but not pregnant women, infants, obese subjects type-1 diabetes mellitus, but the approach has been utilized in these groups. Moreover, in [11], the dependency of C-peptide rate constants, particularly C-peptide evacuation, on subject characteristics is embedded in thresholds (on BMI and glycemic metabolism) rather than being continuous. When the boundaries are crossed, this might cause false variations in C-peptide clearance, which could be problematic in longterm investigations.…”

Section: Assessment Of Thyroxine Secretionmentioning

confidence: 99%

Modelling for Clinical and Psysiological Evaluation of Diabetes and Glucose Homeostasis

Bornmann

2022

JBSHA

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There is a long history of arithmetic simulations in the domain of gluconeogenesis. There are various reasons why frameworks are used. Paradigms have been employed to calculate physiologically relevant parameters from intermediate experimental evidence, to offer a clear quantitative description of pathophysiology processes, and to identify clinical relevance indicators from basic empirical procedures. The creation and application of frameworks in this field has expanded in response to the rising social effect of type 2 diabetes that entails a disruption of the glycemic homeostasis system. The frameworks' emphasis has ranged from depictions of entire body functions to lymphocytes (form “in Vivo” to “in Vitro”) study, following the methodologies of physiologic and medicinal exploration. Framework-based techniques to connecting in vivo and in vitro research, and also multi-resolution systems that combine the two domains, have been presented. The arithmetic and psychological domains have had varying levels of effectiveness and influence.

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Association Between Serum C-Peptide Level and Cardiovascular Autonomic Neuropathy According to Estimated Glomerular Filtration Rate in Individuals with Type 2 Diabetes

Cited by 5 publications

References 34 publications

The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study

The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study

Prevalence and risk factors of diabetic peripheral neuropathy: A population‐based cross‐sectional study in China

Modelling for Clinical and Psysiological Evaluation of Diabetes and Glucose Homeostasis

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