Association between serum calcium levels and first stroke: A community-based nested case-control study

Ding, Congcong; Bi, Chonglei; Lin, Tengfei; Liu, Lishun; Song, Yun; Zhang, Yuanyuan; Wang, Ping; Fang, Chongqian; Ma, Huijie; Huang, Xiao; Xu, Xiping; Zhang, Hao; Hu, Lihua; Huo, Yong; Wang, Xiaobin; Bao, Huihui; Cheng, Xiaoshu

doi:10.3389/fneur.2022.938794

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…These differences might be due to different ethnicities (Pozna ń vs. Moscow) and/or the sizes of the studied populations (260 cases and 291 controls (Table 1) vs. 30 cases and 30 controls [30]). The associations of Al, Na, K, and Ca with stroke in the Polish Central European population of the Pozna ń region of Greater Poland (Table 4) are consistent with previous extensive studies in other populations [23,[37][38][39].…”

Section: Discussionsupporting

confidence: 90%

Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke

Jakubowski,

Sikora,

Bretes

et al. 2024

Life

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Objectives—Metallic elements and fibrin clot properties have been linked to stroke. We examined metallic and nonmetallic elements, fibrin clot lysis time (CLT), and maximum absorbance (Absmax) in relation to ischemic stroke. Design—A case–control study of ischemic stroke patients vs. healthy individuals. Subjects and Methods—Plasma and serum were collected from 260 ischemic stroke patients (45.0% women; age, 68 ± 12 years) and 291 healthy controls (59.7% women; age, 50 ± 17 years). Fibrin CLT and Absmax were measured using a validated turbidimetric assay. Serum elements were quantified by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). Data were analyzed by bivariate correlations and multiple or logistic regression. Results—In female stroke patients, copper, lithium, and aluminum were significantly lower compared with controls; in male stroke patients, potassium was lower, and beryllium was elevated. In female and male stroke patients, iron, zinc, nickel, calcium, magnesium, sodium, and silicon were significantly lower, while strontium was elevated. Positive correlations between fibrin clot properties and metals, observed in healthy controls, were lost in ischemic stroke patients. In multivariate regression analysis, fibrin CLT and/or Absmax was associated with zinc, calcium, potassium, beryllium, and silicon in stroke patients and with sodium, potassium, beryllium, and aluminum in controls. In logistic regression analysis, stroke was independently associated with lithium, nickel, beryllium, strontium, boron, and silicon and with sodium, potassium, calcium, and aluminum but not with fibrin CLT/Absmax. Conclusions—Various elements were associated with fibrin clot properties and the risk of ischemic stroke. Lithium, sodium, calcium, and aluminum abrogated the association of fibrin clot properties with ischemic stroke.

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Section: Discussionsupporting

confidence: 90%

Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke

Jakubowski,

Sikora,

Bretes

et al. 2024

Life

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“…Interestingly, studies have demonstrated that dyscalcemia is related to the risk of cerebrovascular diseases. Ding C et al 12 reported hypocalcemia and hypercalcemia were associated with an increased risk of the first stroke in the Chinese population. Ludhiadch A et al 13 also reported that serum calcium levels may be associated with the determination of infarct size, outcome, and recurrence of ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Serum Calcium is Associated with Sudden Cardiac Arrest after Stroke: An Observational Multicenter Study of the eICU Database

Hou

Huang

Zeng

et al. 2023

Preprint

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The aim of our study was to investigate the association of serum calcium with sudden cardiac arrest (SCA) in patients with stroke. We evaluated the clinical data of 10226 acute stroke patients admitted to the intensive care unit. We assessed the correlation between serum calcium and SCA after acute stroke by multivariate logistic regression. A nonlinear association between platelet count and mortality of HS patients was investigated using a generalized additive model and smooth curve fitting. In this study, we found lower Serum Calcium at admission was associated with SCA of almost two times as high as that for that non-low calcium patients. An increment of per unit in serum calcium was associated with a 49% decrease in SCA. We found that the link between serum calcium at admission and SCA after stroke in the hospital was likewise nonlinear. In addition, we demonstrated that the inflection point of the serum calcium was 8.7 mg/dL. This study demonstrates a nonlinear relationship between serum calcium and the risk of SCA after stroke. Low serum calcium was a risk factor associated with in-hospital SCA after stroke, and elevated serum calcium may be a great intervention for decreasing the incidence of SCA after stroke.

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Serum calcium is associated with sudden cardiac arrest in stroke patients from ICU: a multicenter retrospective study based on the eICU collaborative research database

Hou,

Huang,

Zeng

et al. 2024

Sci Rep

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This primary objective of our study was to investigate the relationship between serum calcium levels and the occurrence of sudden cardiac arrest (SCA) in stroke patients. We analyzed the clinical data of 10,423 acute stroke patients admitted to the intensive care unit. The association between serum calcium and SCA following an acute stroke was assessed through multivariate logistic regression. We explored the non-linear connection between serum calcium levels and SCA in stroke patients using a generalized additive model and smooth curve fitting. Our study uncovered that serum calcium serves as an independent risk factor for sudden cardiac arrest in stroke patients. Notably, we observed that the relationship between serum calcium levels upon admission and the occurrence of SCA in stroke patients within the hospital was non-linear. Furthermore, we identified inflection points in serum calcium levels at 8.2 and 10.4 mg/dL. These findings emphasize a non-linear relationship between serum calcium levels and the risk of SCA in stroke patients. Maintaining serum calcium within the range of 8.2–10.4 mg/dL could lead to a significant reduction in the incidence of cardiac arrest among stroke patients.

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Association between serum calcium levels and first stroke: A community-based nested case-control study

Cited by 6 publications

References 46 publications

Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke

Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke

Serum Calcium is Associated with Sudden Cardiac Arrest after Stroke: An Observational Multicenter Study of the eICU Database

Serum calcium is associated with sudden cardiac arrest in stroke patients from ICU: a multicenter retrospective study based on the eICU collaborative research database

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