Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke

Huang, Guanghan; Ji, Xun Ming; Ding, Yu; Huang, Huai

doi:10.1080/01616412.2016.1187825

Cited by 15 publications

(10 citation statements)

References 43 publications

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“…Its concentration in serum depends almost entirely on kidney function [30,31]. Studies suggest that CysC closely correlates with cardiovascular [22,28] and cerebrovascular diseases [32,33]. In the present study, the sCysC level at ICU admission was a predictor of AKI in patients with stroke, and this finding was consistent with those from studies involving patients undergoing cardiac surgery [25].…”

Section: Discussionsupporting

confidence: 82%

“…In the present study, the sCysC level at ICU admission was a predictor of AKI in patients with stroke, and this finding was consistent with those from studies involving patients undergoing cardiac surgery [25]. Furthermore, Huang et al [32] retrospectively recruited 171 IS patients and found that elevated sCysC was significantly associated with incident IS. Another study from China [33] reported that a high sCysC level positively correlated with 3-month mortality among 365 patients with acute ICH.…”

Section: Discussionsupporting

confidence: 80%

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Incidence, Risk factors, and Biomarkers Predicting Ischemic or Hemorrhagic Stroke Associated Acute Kidney Injury and Outcome: A Retrospective Study in a General Intensive Care Unit

Jiang

Xiang

et al. 2019

Blood Purif

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Objective: We investigated the epidemiology, risk factors, and predictive parameters for ischemic or hemorrhagic stroke-associated acute kidney injury (AKI) and mortality in a general intensive care unit (ICU) in China. Methods: During 5 years, 479 stroke patients were screened, and 381 were enrolled. AKI was diagnosed within 7 days after ICU admission, based on the Kidney Disease Improving Global Outcomes criteria. Risk factors of AKI were assessed by Logistic regression analyses, and the predictive biomarkers for AKI were determined using receiver operating characteristic (ROC) curves. Also examined were factors influencing 28-day mortality, using Cox regression analyses and Kaplan-Meier curves. Results: Among all, 115 (30.18%) patients developed AKI. Multivariate regression analyses revealed that the following features at ICU admission significantly increased the risk of developing AKI: an increased National Institutes of Health Stroke Scale score (OR 1.136, p < 0.001) and Acute Physiology and Chronic Health Evaluation II score (OR 1.107, p = 0.042); hypertension (OR 2.346, p = 0.008); use of loop diuretics (OR 1.961, p = 0.032); and higher serum cystatin C (sCysC; OR 8.156, p = 0.001). The area under the ROC curves for predicting AKI using sCysC was 0.772, slightly better than that of other biomarkers. The sCysC ≥0.93 mg/L (hazard ratio 1.844, p = 0.004) significantly predicted 28-day mortality. Conclusions: Among stroke patients in ICU, we identified significant risk factors of stroke-associated AKI. Serum CysC level at ICU admission was an important biomarker for predicting AKI and 28-day mortality.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 80%

Incidence, Risk factors, and Biomarkers Predicting Ischemic or Hemorrhagic Stroke Associated Acute Kidney Injury and Outcome: A Retrospective Study in a General Intensive Care Unit

Jiang

Xiang

et al. 2019

Blood Purif

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“…In our study, no statistical significance was found in comparing cystatin c level and lipid profile. Matching with our study result, Xiao and colleagues [8] and Huang and colleagues [16] found that CysC levels were not correlated with serum total cholesterol, high-density lipoprotein, and low-density lipoprotein levels. While on the contrary, Xu and colleagues [6] observed a significant correlation with serum CysC levels and serum triglycerides and cholesterol.…”

Section: Discussionsupporting

confidence: 88%

“…So CysC is strongly and independently associated with arterial wall atherosclerosis. Going with our finding, Xiao and colleagues [8] and Huang and colleagues [16] found that serum CysC concentrations in stroke patients were not correlated with hypertension or diabetes. On the other hand, Yang and colleagues [7] observed a significant association between CysC level and hypertension and between CysC and diabetes.…”

Section: Discussionsupporting

confidence: 83%

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Cystatin C as a predictor for carotid artery steno-occlusive disease in non-cardioembolic ischemic stroke

Zaki

Atty

fotouh

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: Stroke is the third leading cause of death in developed nations. Ultrasonography (US) of the carotid arteries is the modality of choice for diagnosis and monitoring of cases of atheromatous disease. Cystatin C (CysC) is a risk factor for cerebrovascular and cardiovascular disease. Objectives: To detect the association of serum CysC levels with acute ischemic stroke, the correlation of its levels with stroke severity, and the association between CysC levels with extra-and intracranial stenosis. Methods: Case-control study was conducted on 66 subjects, 33 patients within the first week of stroke onset with age range from 40 to 75 years, and 33 control healthy subjects with matched age and sex. All subjects underwent complete neurological examination, Extra-and transcranial duplex, CT brain, routine laboratory work-up, and serum CysC. Results: Serum CysC levels were significantly raised in patients with acute ischemic stroke compared to controls. CysC levels were higher in patients with extracranial stenosis than in those with intracranial stenosis. Moreover, extracranial stenosis > 50% has higher levels of CysC. Serum CysC level showed a significant correlation with National Institutes of Health Stroke Scale (NIHSS) and intima-media thickness (IMT). Conclusion: Serum CysC can be used as a marker for acute atherosclerotic ischemic stroke and stroke severity. High-grade extracranial stenosis has the highest level of CysC.

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Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis

Wang

Yang

et al. 2019

J Mol Neurosci

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Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke

Abstract: Our study suggests that there is a close relationship between cystatin C and acute ischemic stroke, independently of conventional risk factors. But the levels of cystatin C are not correlated with the stroke severity.

Cited by 15 publications

References 43 publications

Incidence, Risk factors, and Biomarkers Predicting Ischemic or Hemorrhagic Stroke Associated Acute Kidney Injury and Outcome: A Retrospective Study in a General Intensive Care Unit

Incidence, Risk factors, and Biomarkers Predicting Ischemic or Hemorrhagic Stroke Associated Acute Kidney Injury and Outcome: A Retrospective Study in a General Intensive Care Unit

Cystatin C as a predictor for carotid artery steno-occlusive disease in non-cardioembolic ischemic stroke

Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis

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