Association between serum ferritin and outcomes in critically ill patients: a retrospective analysis of a large intensive care unit database

Sang, Linli; Teng, Weiyun; Zhao, Mengmeng; Ding, Ping; Xu, Xinxiang; Yuxiu, Wang; Cao, Liuzhao

doi:10.1097/cm9.0000000000002019

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…Based on the results from one large research in critical ill patients, the AUCs for ferritin in predicting in-hospital mortality and organ failure were 0.655 and 0.646, respectively. In sepsis, the AUCs for ferritin in predicting in-hospital mortality and organ failure were 0.628 and 0.608, respectively, which the cut-off values were 411 ng/ml and 581 ng/ml, respectively 37 , which were partly similar with our results.…”

Section: Discussionsupporting

confidence: 89%

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

Guo

et al. 2023

Sci Rep

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This study aimed to investigate the relationship between serum ferritin level and prognosis in sepsis. It also explored the potential prognostic value of serum ferritin for predicting outcomes in sepsis based on a large public database. Sepsis patients in MIMIC-IV database were included. Different models including crude model (adjusted for none), model I (adjusted for age and gender) and model II (adjusted for all potential confounders) were performed. Smooth fitting curves were constructed for exploring the relationships between serum ferritin and mortalities of 28-day, 90-day, 180-day and 1-year. Receiver operator characteristic (ROC) curve analysis was utilized for assessing the predictive value of serum ferritin. 1947 sepsis patients were included. The mortalities of 28-day, 90-day, 180-day and 1-year were 20.18% (n = 393), 28.35% (n = 552), 30.30% (n = 590) and 31.54% (n = 614), respectively. In Model II (adjusted for all potential confounders), for every 1000 ng/ml increment in serum ferritin, the values of OR in mortalities of in 28-day, 90-day, 180-day and 1-year were 1.13 (95% CI 1.07–1.19, P < 0.0001), 1.15 (95% CI 1.09–1.21, P < 0.0001), 1.16 (95% CI 1.10–1.22, P < 0.0001) and 1.17 (95% CI 1.10–1.23, P < 0.0001), respectively. The relationships between serum ferritin level and outcomes were non-linear. The areas under the ROC curve (AUC) of ferritin for predicting mortalities of 28-day, 90-day, 180-day and 1-year were 0.597 (95% CI 0.563–0.629), 0.593 (95% CI 0.564–0.621), 0.595 (95% CI 0.567–0.623) and 0.592 (95% CI 0.564–0.620), respectively. The non-linear relationships between serum ferritin and clinical outcomes in sepsis were found. Serum ferritin had a predictive value for short-term and long-term outcomes in sepsis.

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Section: Discussionsupporting

confidence: 89%

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

Guo

et al. 2023

Sci Rep

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“…Observations of serum ferritin dynamics have revealed their capacity to mirror the progression of organ dysfunction and parallel the Sequential Organ Failure Assessment (SOFA) score, thereby offering valuable insights into disease severity and eventual outcomes [ 22 ]. Furthermore, serum ferritin has emerged as a reliable predictor of mortality among critically ill patients, furnishing healthcare providers with crucial prognostic information [ 23 , 24 ]. High serum ferritin levels have consistently been associated with prolonged ICU stays, increased requirements for mechanical ventilation, and adverse clinical outcomes, underscoring its predictive utility in assessing patient prognosis [ 23 , 24 ].…”

Section: Reviewmentioning

confidence: 99%

“…Furthermore, serum ferritin has emerged as a reliable predictor of mortality among critically ill patients, furnishing healthcare providers with crucial prognostic information [ 23 , 24 ]. High serum ferritin levels have consistently been associated with prolonged ICU stays, increased requirements for mechanical ventilation, and adverse clinical outcomes, underscoring its predictive utility in assessing patient prognosis [ 23 , 24 ]. The association between elevated serum ferritin levels and indicators of inflammation, tissue damage, and organ dysfunction in critically ill patients underscores its role as a biomarker for disease severity and progression [ 23 , 24 ].…”

Section: Reviewmentioning

confidence: 99%

“…High serum ferritin levels have consistently been associated with prolonged ICU stays, increased requirements for mechanical ventilation, and adverse clinical outcomes, underscoring its predictive utility in assessing patient prognosis [ 23 , 24 ]. The association between elevated serum ferritin levels and indicators of inflammation, tissue damage, and organ dysfunction in critically ill patients underscores its role as a biomarker for disease severity and progression [ 23 , 24 ]. This relationship highlights the importance of monitoring iron metabolism in ICU patients to assess risk and guide management strategies [ 24 ].…”

Section: Reviewmentioning

confidence: 99%

“…The association between elevated serum ferritin levels and indicators of inflammation, tissue damage, and organ dysfunction in critically ill patients underscores its role as a biomarker for disease severity and progression [ 23 , 24 ]. This relationship highlights the importance of monitoring iron metabolism in ICU patients to assess risk and guide management strategies [ 24 ]. These studies underscore the significance of serum ferritin assessment as a valuable tool for predicting outcomes, monitoring disease progression, and informing clinical decision-making in managing ICU patients.…”

Section: Reviewmentioning

confidence: 99%

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A Comprehensive Review on Serum Ferritin as a Prognostic Marker in Intensive Care Units: Insights Into Ischemic Heart Disease

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Serum ferritin has garnered considerable attention as a prognostic marker in intensive care units (ICUs), offering valuable insights into patient outcomes and clinical management strategies. This comprehensive review examines the role of serum ferritin in predicting outcomes among critically ill patients, with a particular focus on its implications for ischemic heart disease (IHD). Elevated serum ferritin levels have consistently been associated with adverse outcomes in ICU settings, including increased mortality, prolonged hospital stays, and higher morbidity rates. Furthermore, the relationship between serum ferritin levels and IHD underscores its potential as a biomarker for cardiovascular risk assessment in critically ill populations. The review synthesizes existing literature to highlight the predictive value of serum ferritin in assessing illness severity and guiding clinical decision-making in the ICUs. It also explores potential mechanisms linking serum ferritin to adverse outcomes and discusses implications for clinical practice. Integrating serum ferritin measurements into routine assessments could enhance prognostication and risk stratification in ICU patients, while further research is needed to elucidate optimal management strategies and therapeutic targets. Collaborative efforts between clinicians and researchers are essential to advance our understanding of serum ferritin's prognostic value in the ICUs and translate this knowledge into improved patient care and outcomes.

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Association between serum ferritin and outcomes in critically ill patients: a retrospective analysis of a large intensive care unit database

Cited by 6 publications

References 5 publications

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

A Comprehensive Review on Serum Ferritin as a Prognostic Marker in Intensive Care Units: Insights Into Ischemic Heart Disease

COVID Diagnostics: From Molecules to Omics

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