Association between serum free fatty acid levels and possible related factors in patients with type 2 diabetes mellitus and acute myocardial infarction

Abstract

BackgroundFree fatty acids (FFAs) play importance roles in the development of diabetes and cardiovascular diseases. We measured serum FFA levels from type 2 diabetes mellitus (T2DM) and acute myocardial infarction (AMI) patients and assay the correlation between serum FFA levels and related factors. The present study was undertaken to investigate a possible relation between the changes in serum free fatty acid concentration with acute myocardial infarction and type 2 diabetes mellitus.MethodsThe study population consisted of 540 healthy individuals and 103 patients with T2DM, 59 patients with AMI and 21 volunteers. Serum FFAs were measured with high pressure liquid chromatography. Blood urea nitrogen and uric acid were measured in clinical laboratory, as were glycemic, lipid and blood routine parameters. We selected 242 individuals with age over 60 years, 143 healthy individuals and 52 patients with T2DM, 47 patients with AMI were incorporated into three groups as control group, T2DM group and AMI group. Associations were analyzed with stepwise regression analysis with adjusted for age, sex, body mass index.ResultsSerum FFA levels were significantly higher in the age over 60 years individuals compared to 20 ~ 50 years (logFFA μmmol/L:2.60 ± 0.16 vs. 2.73 ± 0.18, P < .001) in the healthy group. We found lower FFA levels in the AMI compared to the T2DM and control group (2.64 ± 0.22 vs. 2.72 ± 0.13&2.72 ± 0.16, respectively, P < .05&P < 0.01) in the age over 60, fasting blood glucose level higher in the AMI and T2DM (5.78 ± 1.32&7.75 ± 2.93 mmol/L vs. 4.90 ± 0.47 mmol/L, P < .01&P < .001) compared with the normal group, HDL level (1.01 ± 0.22&0.98 ± 0.18 mmol/L vs.1.30 ± 0.22 mmol/L, P < .001&P < .001). With stepwise regression analysis, the serum FFA levels was positively associated with the HDL in the control group (YlogFFA = 2.32 + 0.33XHDL, R = 0.26, P < .01) and T2MD (YlogFFA = 2.46 + 0.27XHDL, R = 0.36, P < .05), AST in AMI (YlogFFA =2.24 + 0. 015XAST, R = 0.49, P < .01).ConclusionsCompared to control group, serum FFA levels were decreased only in AMI group, while HDL level was increased in both AMI and T2DM group. The serum FFA levels were positive association with the HDL level in both T2DM and control group, FFA levels were positive association with AST in AMI.

Untitled

“…There was no any statistically significant association between the HbA1c level and the uric acid level in any of our study groups. Higher glucose was seen in AMI cases in Lv et al 20 In this study, we can say that the serum uric acid level on raise with increase in fasting plasma glucose in group I, but seems to be decreasing in group II. This was found to be similar with Cirakli ZL et al 17 and Nan H et al 21 studies.…”

Autophagy mediates free fatty acid effects on MDA-MB-231 cell proliferation, migration and invasion

“…The data presented in the present study demonstrated that PA promotes MDA-MB-231 cell apoptosis and invasion while OA promotes proliferation, migration and invasion. Although FFA levels are generally elevated in breast cancer patients ( 19 , 20 ), the role of FFA in health and disease in humans has been minimally investigated and understood.…”

Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke

“…An elevated FFA concentration is linked to several risk factors for atherosclerosis (5), including acute myocardial infarction (17), cardiovascular disease (8), heart failure (10), and atrial fibrillation (AF) (16). Pathological processes, including ischemia and subarachnoid hemorrhage, result in significant increases in brain concentrations of free fatty acids (FFAs) in animal studies (13).…”