Association between Serum Fructosamine and Kidney Function in Nondiabetic Individuals without Chronic Kidney Disease

Abstract

BackgroundSerum fructosamine (SF) has been considered to be an indicator that estimates glycemic control in patients with diabetes mellitus (DM). There is increasing evidence that SF concentration and oxidative stress are significantly elevated in patients with chronic kidney disease (CKD). However, the data about SF and its association with kidney function are lacking in nondiabetic individuals without CKD. We included 1891 nondiabetic individuals who had not been diagnosed with CKD to determine the association between SF and kidney function.Material/MethodsWe conducted a retrospective analysis on the basis of the biochemistry database in nondiabetic individuals without CKD.ResultsWhen eligible participants were stratified in accordance with SF quartiles, from the bottom to the top quartile of SF, a significant decrease of estimated glomerular filtration rate (GFR) was observed in baseline data. SF concentration was negatively associated with estimated GFR (r=−0.066, P=0.004) in the Pearson correlation analysis. Estimated GFR was associated with SF levels independently of glucose (GLU), total cholesterol (TC), triglyceride (TG), and total protein (TP) in multivariable logistic regression analysis (OR=0.984; CI 95% 0.977–0.991; P<0.001).ConclusionsWe suggest that mild elevation of SF concentration is associated with estimated GFR in nondiabetic individuals without CKD. These findings indicate that SF may underlie CKD in nondiabetic individuals.

The significance of routine biochemical markers in patients with major depressive disorder

“…However, these tools are uncommon and unavailable in the clinical laboratory. Recent studies have shown that several laboratory markers are associated with systemic inflammation and oxidative stress, such as urea nitrogen (UN), creatinine (Cr), fructosamine (SF) and bilirubin 11 12 . Unfortunately, their single use is often limited by poor sensitivity and specificity.…”

The relationships between serum fructosamine concentrations and lipid profiles in community-dwelling adults

“…Peng et al . 5 reported a positive correlation between serum fructosamine and estimated glomerular filtration rate in non-diabetic individuals. Previous studies have demonstrated that higher serum fructosamine levels were associated with coronary artery atherosclerosis, dementia and renal failure 6 – 9 .…”