Association between serum gamma-glutamyltransferase and early-onset coronary artery disease: a retrospective case-control study

Xuan, Chao; Li, Jing; Liu, Ru-Hua; Guo, Jun-Jie; Zhao, Cong; Zhou, Ting-Ting; Wang, Yan; He, Guo-Wei; Lun, Li-Min

doi:10.1080/07853890.2023.2289606

Annals of Medicine

2023

DOI: 10.1080/07853890.2023.2289606

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Association between serum gamma-glutamyltransferase and early-onset coronary artery disease: a retrospective case-control study

Chao Xuan,

Jing Li,

Ru-Hua Liu

et al.

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2024

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Cited by 3 publications

References 44 publications

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Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of coronary heart disease incidence

He,

Chen,

Zhu

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of coronary heart disease incidence

He,

Chen,

Zhu

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient

Virgolici,

Dobre,

Lixandru

et al. 2024

Romanian Journal of Internal Medicine

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Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity. Methods. Eighty-five type 2 diabetes, aged 40–70 years with a duration of diabetes less than 6 years without infections, epilepsy, chronic liver or cardiac diseases, without alcohol consumption (>20 g/day) were divided in two subgroups, those with normal and those with high abnormal GGT. Results. The diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher inflammatory markers (CRP, TNF-α, MCP-1) and endothelial dysfunction (high leptin and sICAM). sICAM, serum MCP-1 and TNF-α levels had significant correlations with GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p<0.05). Conclusion. This study underlines that in non-alcoholic diabetic patients, with a duration of the metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-α might play an important role in dysmetabolism, and higher level for GGT represents the „red flag” for this condition.

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The relationship between early-onset coronary artery disease and familial hypercholesterolemia: a cohort study based on the Hakka population in Meizhou, China

Yang

2024

Am J Transl Res

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Association between serum gamma-glutamyltransferase and early-onset coronary artery disease: a retrospective case-control study

Cited by 3 publications

References 44 publications

Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of coronary heart disease incidence

Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of coronary heart disease incidence

The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient

The relationship between early-onset coronary artery disease and familial hypercholesterolemia: a cohort study based on the Hakka population in Meizhou, China

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