Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women

Mabuchi, Tomoko; Yatsuya, Hiroshi; Koji, Takehiko; Otsuka, Rei; Nagasawa, Natsuko; Zhang, Huiming; Murata, Chiyoe; Wada, Keiko; Ishikawa, Miyuki; Hori, Yoko; Kondo, Takaaki; Hashimoto, Shuji; Toyoshima, Hideaki

doi:10.1002/dmrr.540

Cited by 26 publications

(20 citation statements)

References 35 publications

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“…Obesity and current smoking were found to be independently associated with elevated WBC counts, both of which are consistent with previous reports [9][10][11][15][16][17] . In addition, higher cigarette consumption (more than 20 cigarettes per day) was positively associated with WBC counts in men.…”

Section: Discussionsupporting

confidence: 92%

Having More Healthy Practice was Associated with Low White Blood Cell Counts in Middle-aged Japanese Male and Female Workers

et al. 2008

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Section: Discussionsupporting

confidence: 92%

Having More Healthy Practice was Associated with Low White Blood Cell Counts in Middle-aged Japanese Male and Female Workers

et al. 2008

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“…Multivariate adjustment was made for age and BMI (Model 1), and further adjustment was conducted for the factors of smoking status (current, former, never), drinking habits (none, light: daily alcohol consumption approximately less than 23 g; moderate: 23-46 g; heavy: 46 g or over), leisure-time physical activity (regularly active, somewhat active, not very active), and a present history of any treatment for hypertension, diabetes, dyslipidemia, stroke, or hyperuricemia (Model 2). The classification method for the intensity of both drinking habits and leisure-time physical activity has been thoroughly described in a previous paper [24]. To test the linear trend for each glycemic index according to the polyamine concentrations, we used a linear contrast on the assumption that the polyamine quartiles were equally spaced from low to high.…”

Section: Discussionmentioning

confidence: 99%

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase

Kondo

Yamamoto

Kimata

et al. 2007

Environ Health Prev Med

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Objectives Polyamines have long been known to have an insulin-like action, but their antiglycating effect has only recently attracted the attention of researchers. The aim of our investigation was to determine the whole blood polyamine concentration in a healthy population in order to examine its relationship with glycemic profiles. Methods The study cohort comprised 622 men aged 40-59 who participated in a health checkup program conducted in 1997, when they underwent measurements of fasting plasma glucose (FPG), insulin (FPI), and fructosamine as glycemic indices. Colorimetric assay methods using oat and barley seedling polyamine oxidase were used to determine total polyamine (spermidine + spermine) and spermine concentrations in the whole blood, respectively. Polyamine concentrations adjusted for hemoglobin were quartiled for the analysis of covariance to assess the association with glycemic indices. Results A significant association was demonstrated between the FPG and total polyamine concentrations. In the trend test, FPG and fructosamine levels increased in accordance with the shift of quartiles of total polyamine concentrations from low to high. In contrast, the association between the spermine and glycemic indices was not statistically significant based on the test for difference of multivariate-adjusted means or trend for linearity. Conclusions This is the first epidemiological study to reveal that the concentrations of blood polyamines are related with either FPG or fructosamine level in a healthy population. There may be some feedback mechanism for the elevation of circulating polyamines to quench the glycation reaction under hyperglycemic conditions. In addition, total polyamines, rather than spermine alone, seem to be a sensitive biomarker representing the antiglycation effect of polyamines.

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“…13) The classification method for the intensity of leisure-time physical activity has been described in our previous paper. 14) The intercept α j represents the average BP for the j th individual with an average cBMI across all of his examinations, and ε i j denotes the error components accounting for his within-individual variability. The regression coefficient β j is used to model the linear rate of BP change to cBMI.…”

Section: Methodsmentioning

confidence: 99%

Effects of Short-term Variation in Body Mass Index on Blood Pressure in Middle-aged Japanese Male Workers

Kondo

Kimata

Yamamoto

et al. 2009

JOURNAL OF HEALTH SCIENCE

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We attempted to perform multilevel analyses to explore whether a year-to-year weight variation causes any corresponding effects on blood pressure (BP) among middle-aged Japanese workers. Subjects were 4547 healthy male workers 40-59 in age from whom serial data of systolic and diastolic BP were collected during health checkups conducted in the years 1997-2000. The effects on BP of a time-varying body mass index (BMI) that was rescaled to center around the individual-specific mean of 4 examinations on BP were investigated by statistical analysis with multilevel modeling to adjust for the wide variability among individuals. A significant relationship between the time-varying BMI and both systolic and diastolic BP was confirmed. None of the interaction terms for BMI × potential effect modifiers (smoking history, drinking status, leisure-time physical activity, and preference for salty taste) included in the subanalysis model showed any significant modifying effect. Our result indicated that the year-to-year weight variation, though usually in a much narrower range than the between-individual variation, has a strong impact on the corresponding BP. This result supports the public health significance of interventions in short-term weight control to prevent the development of hypertension among an otherwise healthy workplace population.

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Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women

Abstract: Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration.

Cited by 26 publications

References 35 publications

Having More Healthy Practice was Associated with Low White Blood Cell Counts in Middle-aged Japanese Male and Female Workers

Having More Healthy Practice was Associated with Low White Blood Cell Counts in Middle-aged Japanese Male and Female Workers

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase

Effects of Short-term Variation in Body Mass Index on Blood Pressure in Middle-aged Japanese Male Workers

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