Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review

Abstract

25-(OH)D appears to be implicated in structural changes of knee OA rather than symptoms, and further well-designed RCTs are required to determine whether vitamin D supplementation can slow disease progression. There is insufficient evidence for other sites.

Vitamin D deficiency showed association with knee osteoarthritis in Tamilnadu population – A pilot study

“…6,8,13,16 Low serum 25-OH vitamin D increases osteoblastic activity and bone turnover. 1,9,14,17 Many mechanisms were put forwarded to explain role of vitamin D and alterations in properties of bones in the progression of the disease osteoarthritis. Increasing bone resorption by the elevated levels of parathyroid hormone (PTH) increasing bone turn over, or effect of vitamin D metabolites directly on articular chondrocytes were some of the mechanisms put forwarded to explain the role of vitamin D deficiency in osteoarthritis.…”

“…12,16 In a recent study, decreased serum level of 25-hydroxy vitamin D was reported in a significant proportion of patients with OA of hip and knee joints. 14,[16][17][18][19] All these epidemiological suggests that by achieving normal serum vitamin D level may prevent or delay loss of cartilage loss and reduce the pain and other symptoms of OA. [15][16][17][18] Observation from studies on knee osteoarthritis evaluated by Cao et al suggested that serum 25-OH vitamin D level play an important role in structural changes of knee osteoarthritis.…”

“…14,[16][17][18][19] All these epidemiological suggests that by achieving normal serum vitamin D level may prevent or delay loss of cartilage loss and reduce the pain and other symptoms of OA. [15][16][17][18] Observation from studies on knee osteoarthritis evaluated by Cao et al suggested that serum 25-OH vitamin D level play an important role in structural changes of knee osteoarthritis. 17 In another study done by Bergink et al also, reported three times increased risk of knee OA and disease progress was associated with serum 25-OH vitamin D <20 ng/ml in the Rotterdam Study.…”

“…[15][16][17][18] Observation from studies on knee osteoarthritis evaluated by Cao et al suggested that serum 25-OH vitamin D level play an important role in structural changes of knee osteoarthritis. 17 In another study done by Bergink et al also, reported three times increased risk of knee OA and disease progress was associated with serum 25-OH vitamin D <20 ng/ml in the Rotterdam Study. 18 In patients with hip OA who underwent total hip replacement, 25-hydroxy vitamin D levels were found to have positive correlation with both pre and post-operative Harris hip scores.…”

Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions

“…Based on prior recommendations (Cao et al, 2013), we used the following grading system. Strong evidence: 2 high-quality studies in agreement about an outcome; moderate: 1 high-quality + 1 medium quality, or 3 medium-quality studies in agreement; low: 1 high quality, or 2 medium-quality, or 3 low studies in agreement; no evidence: 1 medium-quality study, or < 3 studies of low quality studies, or any number of no quality studies in agreement, or no studies at all; conflicting: contrasting findings of low to strong evidence among studies.…”