Association Between Serum Levels of Testosterone and Estradiol With Meibomian Gland Assessments in Postmenopausal Women

Ablamowicz, Anna F; Nichols, Jason J.; Nichols, Kelly K.

doi:10.1167/iovs.15-18158

Cited by 37 publications

(23 citation statements)

References 47 publications

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“…In a separate study, venous blood sampling and meibography were used to evaluate the association between serum levels of testosterone and estradiol and MG morphology in postmenopausal women ( n = 198, average age 61.2 [±9.1] years). 52 MG dropout increased with higher testosterone levels, and a significant difference in testosterone levels was observed in the mild versus severe MG dropout groups (MG dropout scores of 1 and 4, respectively; p = 0.002). Differences were not significant with estradiol and meibography assessments ( p = 0.53).…”

Section: Biological Sex and Hormonal Differences In Ocular Structurementioning

confidence: 90%

Dry Eye Disease: Consideration for Women's Health

Matossian

McDonald

Donaldson

et al. 2019

Journal of Women's Health

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100

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Dry eye disease (DED) is a multifactorial disorder of the ocular surface and tear homeostasis that can result in discomfort, pain, and visual disturbance. Untreated, DED can become chronic, progressive, and significantly affect an individual's quality of life. Women are disproportionately affected by DED, are diagnosed at a younger age, and experience more severe symptoms compared with men. DED is associated with a wide range of comorbid conditions; there is a strong association between DED and autoimmune disorders, especially those that affect women at many times the rate of men. Treatment response questionnaires indicate women respond better to a wellness model of treatment for DED than men. Furthermore, women's health care-seeking behaviors provide opportunities for general practitioners, specialists, and women's health centers to help identify women with DED or at risk for DED for referral to an eye care specialist. This review of the prevalence of DED in women, and gender and sex-specific aspects of DED, highlight a significant opportunity for action. Earlier diagnosis and treatment of this common but burdensome condition could significantly improve a woman's quality of life.

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Section: Biological Sex and Hormonal Differences In Ocular Structurementioning

confidence: 90%

Dry Eye Disease: Consideration for Women's Health

Matossian

McDonald

Donaldson

et al. 2019

Journal of Women's Health

Self Cite

100

View full text Add to dashboard Cite

show abstract

“…It should be noted that hormonal and environmental influences on the structure of meibomian glands may be confounding factors in such studies, however. 28,29…”

Section: Agingmentioning

confidence: 99%

Meibography: A Japanese Perspective

Arita

2018

Invest. Ophthalmol. Vis. Sci.

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Meibography allows observation of meibomian glands in an objective and repeatable manner. Original meibography systems were invasive and not readily adopted by ophthalmology clinics. The development of noncontact infrared meibography allowed the rapid and noninvasive observation of meibomian glands, and such systems have now been widely adopted for standard examinations in dry eye clinics. Noncontact meibography has also spurred research into meibomian glands and has been applied to evaluation of their structure and status in various ocular surface diseases. Although the images obtained by meibography are objective and repeatable, the interpretation of these images is subjective, with the relationship between image features and actual gland structure and composition remaining unclear. Additional clinical and basic research with regard to the interpretation of meibography images is thus necessary. Future improvements to meibography will likely provide new insights into the pathophysiology of meibomian gland diseases as well as enhance its contribution to the diagnosis and evaluation of treatments for such diseases.

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“…9 This finding was also different to a study conducted by Anna et al where the mean age was 61.2±9.1 years. 11 In this study significant association was found between dry eye disease and increasing age. Similar findings were found in a study conducted in Australia where the odds for developing dry eyes were 1.04 at 95% CL=1.01, 1.06).…”

Section: Discussionmentioning

confidence: 50%

A study on prevalence of dry eyes among menopausal women attending a tertiary care centre in Hyderabad, Telangana

Kumar¹,

Asma²,

Praneetha³

et al. 2018

Int J Community Med Public Health

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Background: Dry eye syndrome arises due to chronic lack of sufficient lubrication and moisture on the surface of the eye. Symptoms of dry eye syndrome includes burning sensation, itchy eyes, blurred vision, and fatigued eyes, redness of eyes, gritty and dry eye sensation / foreign body sensation. Studies reveal that post-menopausal women are at greater risk of developing dry eyes than men of same age. Aims and objectives were to determine the prevalence of dry eye syndrome among post-menopausal women at tertiary care center, Hyderabad and to assess the socio-demographic factors related to dry eye syndrome among study population.Methods: A cross sectional study was carried out from March to June 2017 among post-menopausal women attending Gandhi Hospital, in Hyderabad, Telangana. A convenient sample of 200 post-menopausal women was taken. Schirmer’s test was used to determine presence of dry eyes.Results: The mean age of study population was found to be 51.66±5.8 years. The mean age of onset of menopause in study subjects was 45.63±1.8 years. The prevalence of dry eye syndrome was found to be 39.5%. Mild dryness of eyes was most common among study subjects (20.5%). Prevalence of dry eyes increased with age and had significant association.Conclusions:Dry eye syndrome is not a life threatening disease, but causes ocular discomfort and compromises quality of life. If neglected, can even lead to blindness and debility due to complications arising due to dry eye.

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Association Between Serum Levels of Testosterone and Estradiol With Meibomian Gland Assessments in Postmenopausal Women

Cited by 37 publications

References 47 publications

Dry Eye Disease: Consideration for Women's Health

Dry Eye Disease: Consideration for Women's Health

Meibography: A Japanese Perspective

A study on prevalence of dry eyes among menopausal women attending a tertiary care centre in Hyderabad, Telangana

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