Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders

Abstract

Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study. Clinical data were obtained by Positive and Negative Syndrome Scale (PANSS), and Calgary Depression Scale for Schizophrenia (CDSS). Blood samples were analyzed for total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), C-reactive protein (CRP), soluble tumor necrosis factor receptor 1(sTNF-R1), osteoprotegerin (OPG), and interleukin 1 receptor antagonist (IL-1Ra). After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [β = 0.13, p = 0.007; β = 0.14, p = 0.007], and with two inflammatory markers: CRP [β = 0.14, p = 0.007; β = 0.16, p = 0.007] and OPG [β = 0.14, p = 0.007; β = 0.11, p = 0.007]. Total model variance was 17% for both analyses [F(12, 433) = 8.42, p < 0.001; F(12, 433) = 8.64, p < 0.001]. Current findings highlight a potential independent role of depression and inflammatory markers, CRP and OPG in specific, in the pathophysiology of dyslipidemia in psychotic disorders.

Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders

“…The methodology used for drawing, processing and storage of blood samples have been described previously (24). Some of these biological markers have been reported previously by us in relation to other outcome measures (25)(26)(27)(28)(29)(30).…”

A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

“…Depression may be associated with lipid profiles and inflammatory cytokines [28, 29]. In this study, after categorization by depression status, a significant association was found between depression status and waist circumference, fat percentage, diastolic blood pressure, LDL, TG, and FBS.…”

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

“…In addition, accumulating evidence suggests that various psychiatric disorders including depression can be affected by the altered lipids levels (TC, TG, LDL, and HDL). 18,19 Lipids are found to be involved in the neuronal function of the brain, influencing emotional behaviours and mental disorders. 20 Depression and elevated total cholesterol are identified as an independent and potent risk factor for cardiovascular disease.…”