Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study

Ta, D'Ascoli; Mursu, Jaakko; Voutilainen, Sari; Kauhanen, Jussi; Tp, Tuomainen; Virtanen, Jyrki K.

doi:10.1038/ejcn.2016.59

Cited by 32 publications

(13 citation statements)

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“…Verbal Fluency is one of multiple domains found to be impaired in UHR populations compared to healthy controls (Hauser et al, 2017) and poorer performance in this domain was also observed in those who transition to psychosis compared to those who do not (Becker et al, 2010;Hauser et al, 2017). While there has been limited research specifically investigating Verbal Fluency and PUFAs in populations with an at risk mental state of psychosis, the present research is partially consistent with research by D' Ascoli et al (2016) who found Verbal Fluency was positively associated with serum EPA and DHA in a healthy aging population (D'Ascoli et al, 2016). While the positive association between Verbal Fluency and EPA is consistent with this research, and the neurocognition literature more broadly (Satogami et al, 2017), the negative association with DHA is inconsistent.…”

Section: Discussionsupporting

confidence: 89%

Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

McLaverty

Allott

Berger

et al. 2020

Early Intervention Psych

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Background: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations.Method: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/ omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking.

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Section: Discussionsupporting

confidence: 89%

Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

McLaverty

Allott

Berger

et al. 2020

Early Intervention Psych

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“…Administration of omega-3 prevented both short- and long-term memory impairment in OMG/PTSD. Current findings are in agreement with results of other studies that examined the protective effects of omega-3 on cognitive impairment associated with different conditions [44,45].…”

Section: Discussionsupporting

confidence: 92%

Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment

et al. 2019

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Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can happen after exposure to a traumatic event. Post-traumatic stress disorder is common among mental health disorders that include mood and anxiety disorders. Omega-3 fatty acids (OMGs) are essential for the maintenance of brain function and prevention of cognition dysfunctions. However, the possible effect of OMG on memory impairment induced by PTSD has not been studied. In here, such an effect was explored using a rat model of PTSD. The PTSD-like behavior was induced in animals using a single-prolonged stress (SPS) rat model of PTSD (2 h restraint, 20 min forced swimming, 15 min rest, 1–2 min diethyl ether exposure). The OMG was administered orally at a dose of 100 mg omega-3 polyunsaturated fatty acid (PUFA)/100 g body weight/day. Spatial learning and memory were assessed using the radial arm water maze (RAWM) method. Changes in oxidative stress biomarkers, thiobarbituric acid reactive substances (TBARS), and brain derived neuroptrophic factor (BDNF) in the hippocampus following treatments were measured. The results revealed that SPS impaired both short- and long-term memory (p < 0.05). Use of OMG prevented memory impairment induced by SPS. Furthermore, OMG normalized SPS induced changes in the hippocampus that reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratios, the activity of catalase, glutathione peroxidase (GPx), and TBARSs levels. In conclusion, the SPS model of PTSD-like behavior generated memory impairment, whereas OMG prevented this impairment, possibly through normalizing antioxidant mechanisms in the hippocampus.

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“…Second, owing to the lack of an omega-3 fatty acids database, the intake of omega-3 fatty acids from fish could not be considered a covariable. Third, the effects of methylmercury on fish cannot be excluded, since methylmercury may attenuate the health benefits of omega-3 fatty acids [34]. However, the current evidence suggests that the benefits of consuming 1 to 2 servings of fish per week outweigh the risks, especially if a variety of seafood are consumed [8].…”

Section: Discussionmentioning

confidence: 99%

Oily Fish Consumption and the Risk of Dyslipidemia in Korean Adults: A Prospective Cohort Study Based on the Health Examinees Gem (HEXA-G) Study

et al. 2019

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Despite the beneficial effects of omega-3 fatty acids from fish or fish oil on cardiovascular diseases, limited information is available regarding the effects of oily fish in the diet on the risk of dyslipidemia. This study aimed to investigate the association between oily fish consumption and the incidence of dyslipidemia among Korean adults included in the Health Examinees Gem (HEXA-G) cohort during 5 years of follow-up. In total, 20,670 participants (5710 men and 14,960 women) were included in this study. The average intake of oily fish including dark meat fish, such as mackerel, pacific saury, and Spanish mackerel, and eel, was estimated using food frequency questionnaires. Oily fish consumption was associated with a significantly lower risk of hypertriglyceridemia in both men (Relative risk (RR) comparing extreme quintiles = 0.75; 95% CI 0.60–0.95; P for trend = 0.0121) and women (RR comparing extreme quintiles = 0.81; 95% CI 0.69–0.96; P for trend = 0.0110) after adjusting for potential confounders. In conclusion, increased consumption of oily fish was significantly associated with a lower risk of hypertriglyceridemia in the general Korean population. Future randomized clinical trials or prospective studies are required to confirm these findings in the Korean or other Asian populations.

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Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study

Abstract: Higher serum long-chain omega-3 PUFA concentrations were associated with better performance on neuropsychological tests of frontal lobe functioning in older men and women. Mercury exposure or Apo-E4 phenotype had little impact on cognitive performance.

Cited by 32 publications

References 50 publications

Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment

Oily Fish Consumption and the Risk of Dyslipidemia in Korean Adults: A Prospective Cohort Study Based on the Health Examinees Gem (HEXA-G) Study

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