Association Between Serum Magnesium and the Prevalence of Kidney Stones: a Cross-sectional Study

Wu, Jing; Yang, Zidan; Wei, Jie; Zeng, Chao; Wang, Yilun; Yang, Tubao

doi:10.1007/s12011-019-01830-3

Cited by 19 publications

(11 citation statements)

References 41 publications

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“…Firstlevel evidence supports the use of magnesium in the prevention of many common health conditions such as migraine headache, asthma, premenstrual syndrome, preeclampsia, various cardiac arrhythmias and metabolic disorders (obesity, diabetes, changes in lipid metabolism, and hypertension) (10,11). Magnesium has also been considered an adjunct for depression, attention de cit disorder, and kidney stone prevention (12,13). A cohort study showed that low serum Mg 2+ levels are signi cantly associated with the risk of all-cause mortality in a community-based population (14).…”

Section: Discussionmentioning

confidence: 99%

Seizure-like Symptoms Induced by Hypomagnesemia in a Patient with Incomplete Small Bowel Obstruction: A Case Report and Literature Review

Zhu

Weng

2023

Preprint

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Background Seizure-like symptoms are rare in older patients without brain damage. Small bowel obstruction is a common clinical disorder for older patients that can cause electrolyte disturbances and nutritional disorders. Hypomagnesemia is a frequently overlooked electrolyte disorder. Moreover, magnesium deficiency can lead to severe seizure-like symptoms. Case presentations: An 85-year-old man was admitted to the hospital with weakness and slow movement. Shortly after hospitalization, he experienced incomplete small bowel obstruction; thus, parenteral nutrition and intravenous esomeprazole were administered. When intestinal obstruction was relieved, the patient suddenly experienced seizure-like symptoms three times, and 24-h electroencephalogram did not capture any epileptiform pattern. After excluding other causes, we considered serum magnesium deficiency as a diagnosis. Low serum magnesium levels were related to a shortage of absorption due to small bowel obstruction, excess excretion of renal dysfunction, and the use of proton pump inhibitor. However, the exact mechanism underlying the hypomagnesemia-induced seizure-like activity remained unclear. After adjusting the nutritional support and magnesium supplementtion, the patient’s serum magnesium level returned to normal and he was free of seizure-like activity. Conclusion Hypomagnesemia is often asymptomatic, but it can lead to severe seizure-like symptoms. It is important to pay attention to the serum magnesium level and nutritional intake in patients with an incomplete small bowel obstruction.

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Section: Discussionmentioning

confidence: 99%

Seizure-like Symptoms Induced by Hypomagnesemia in a Patient with Incomplete Small Bowel Obstruction: A Case Report and Literature Review

Zhu

Weng

2023

Preprint

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“…As the body ages, magnesium levels naturally decline. Magnesium deficiency has been associated with increased production of free radicals, consequently promoting oxidative stress and chronic inflammation ( 45 ), closely linked to the development of kidney stones ( 19 ). Adults are recommended to consume 320–420 mg of magnesium per day, and a single cup (234 ml) of low-fat milk contains approximately 33 mg of magnesium ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Association between milk consumption and kidney stones in U.S. adults: results from NHANES 2007–2018

Xie,

Zhuang,

Peng

et al. 2024

Front. Nutr.

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BackgroundDietary strategies play a crucial role in the prevention of kidney stones. While milk is known for its rich nutritional content, its impact on kidney stone formation remains unclear. This study aimed to examine the relationship between milk consumption and the risk of kidney stones among U.S. adults.MethodsWe included 24,620 participants aged 20 and older from the National Health and Nutrition Examination Survey (2007–2018). Milk consumption was defined based on each participant’s response to the questionnaire item on “Past 30 day milk product consumption.” Kidney stones history was self-reported by participants. The analysis employed weighted multivariate logistic regression models, followed by subgroup analyses for result validation, and explored the age-related dynamics of milk consumption’s effect on kidney stone risk using a restricted cubic spline model.ResultsAdjusted findings revealed that higher milk intake was associated with a decreased risk of kidney stones (odds ratio [OR] = 0.90, 95% confidence interval [CI] 0.85–0.96), notably among women (OR = 0.86, 95% CI 0.80–0.92) but not significantly in men (OR = 0.94, 95% CI 0.86–1.02). Smoothed curves across all ages showed that women consuming milk had a lower incidence of kidney stones than those who did not, particularly with regular consumption.ConclusionThis study uncovered that across all age groups, higher frequency of milk consumption in women is associated with a reduced risk of kidney stones. However, further prospective cohort studies are needed to confirm this finding.

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“…Depending on the results obtained from the basic metabolic analysis, we can add to the hematological search another parameter like the parathormone if hypercalcemia is found [17] or serum magnesium, which in the case of being low could correlate to a higher prevalence of kidney stones [18]. Other parameters would be bicarbonate, phosphate, and calcitriol.…”

Section: Extensive Blood Analysismentioning

confidence: 99%

Metabolic evaluation: is there really a future?

Traxer

Corrales

Sierra

2022

Current Opinion in Urology

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Purpose of reviewTo confirm the need for a metabolic evaluation in stone formers based on the latest information published in the last 24 months and in the current 2022 American and European urological guidelines. Recent findingsRecent studies suggest that urolithiasis prevalence has been increasing since 1990. Along with it, metabolic abnormalities that contribute to the development of kidney stones are also increasing, such as hyperuricosuria, hyperoxaluria, hypocitraturia, hypomagnesuria, hypocalciuria, hypophosphaturia, and hyperuricemia. Those abnormalities can only be detected through a metabolic evaluation in patients with stone disease.

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Association Between Serum Magnesium and the Prevalence of Kidney Stones: a Cross-sectional Study

Cited by 19 publications

References 41 publications

Seizure-like Symptoms Induced by Hypomagnesemia in a Patient with Incomplete Small Bowel Obstruction: A Case Report and Literature Review

Seizure-like Symptoms Induced by Hypomagnesemia in a Patient with Incomplete Small Bowel Obstruction: A Case Report and Literature Review

Association between milk consumption and kidney stones in U.S. adults: results from NHANES 2007–2018

Metabolic evaluation: is there really a future?

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