Association between serum trace element, mineral, and amino acid levels with non-alcoholic fatty liver disease (NAFLD) in adult women

Tinkov, Alexey A.; Korobeinikova, Tatiana V.; Morozova, Galina D.; Aschner, Michael; Mak, Daria V.; Santamaria, Abel; Rocha, Joao B.T.; Sotnikova, Tatiana I.; Tazina, Serafima Ia.; Skalny, Anatoly V.

doi:10.1016/j.jtemb.2024.127397

Journal of Trace Elements in Medicine and Biology

2024

DOI: 10.1016/j.jtemb.2024.127397

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Association between serum trace element, mineral, and amino acid levels with non-alcoholic fatty liver disease (NAFLD) in adult women

Alexey A. Tinkov,

Tatiana V. Korobeinikova,

Galina D. Morozova

et al.

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Cited by 2 publications

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Copper and liver fibrosis in MASLD: the two-edged sword of copper deficiency and toxicity

Lonardo,

Weiskirchen

2024

Metab Target Organ Damage

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Copper is a trace metal whose absence or deficiency can cause structural and functional alterations that can be corrected by copper administration. Copper excess is associated with significant liver toxicity, such as that seen in Wilson’s disease, which often exhibits liver steatosis and can be managed by copper sequestrants. Copper, due to its ability to either accept or donate electrons, is a cofactor in many physiological redox reactions, playing an essential role in cell energy homeostasis, detoxification of reactive oxygen species, and hepatic immunometabolism. Given these facts, it is reasonable to speculate that copper might be involved in the pathogenesis of liver fibrosis in the setting of metabolic dysfunction-associated fatty liver disease (MASLD). To address this research question, a narrative review of published studies was conducted, spanning from the needs, sources, and toxicity of copper to Menkes and Wilson’s disease. Most epidemiological studies have demonstrated that MASLD is associated with copper deficiency. However, several studies show that MASLD is associated with copper excess and very few conclude that copper is not associated with MASLD. Therefore, the putative pathomechanisms associating both copper excess and deficiency with MASLD development and progression are reviewed. In conclusion, epidemiological and pathogenic data support the notion that well-balanced copper homeostasis is a prerequisite for liver health. Accordingly, both copper excess and deficiency may potentially predispose to liver fibrosis via the development of MASLD. Therefore, studies aimed at restoring normal bodily stores of copper should be tailored according to precision medicine approaches based on the specific features of copper metabolism in individual MASLD patients.

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Copper and liver fibrosis in MASLD: the two-edged sword of copper deficiency and toxicity

Lonardo,

Weiskirchen

2024

Metab Target Organ Damage

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Impact of dietary selenium and blood concentration on liver function: a population-based study

Liang,

Huang,

Peng

et al. 2024

Front. Nutr.

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BackgroundEvidence on the association between selenium and liver function parameters is limited and controversial.MethodsData on dietary selenium intake, blood selenium concentration, and liver function parameters were obtained from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Associations between selenium (dietary intake and blood concentration) and liver function parameters [alanine aminotransferase (ALT), aspartate aminotransferase (AST), the ALT/AST ratio, gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)] were assessed using multivariate linear regression models. Subgroup analyses and interaction tests were conducted to examine differences in associations according to age, gender, body mass index (BMI), diabetes, and physical activity.ResultsThe study included 6,869 participants after screening. The multivariate linear regression model revealed that dietary selenium intake was positively associated with ALT (β = 0.112, 95% CI = 0.041, 0.183) and the ALT/AST ratio (β = 0.002, 95% CI = 0.001, 0.004) after adjustment for covariates. Results of blood selenium concentration also showed that higher blood selenium levels were positively associated with ALT (β = 0.436, 95% CI = 0.308, 0.564), AST (β = 0.112, 95% CI = 0.015, 0.208), and the ALT/AST ratio (β = 0.012, 95% CI = 0.009, 0.015). However, ALP decreased with increasing blood selenium concentration (β = −0.207, 95% CI = −0.414, −0.000). In addition, we found significant differences in the effect of selenium on liver function parameters according to age, gender, and BMI.ConclusionDietary selenium intake and blood concentration affect liver function parameters. These findings suggest that further research is needed to explore these associations to promote liver health and disease prevention.

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Association between serum trace element, mineral, and amino acid levels with non-alcoholic fatty liver disease (NAFLD) in adult women

Cited by 2 publications

References 116 publications

Copper and liver fibrosis in MASLD: the two-edged sword of copper deficiency and toxicity

Copper and liver fibrosis in MASLD: the two-edged sword of copper deficiency and toxicity

Impact of dietary selenium and blood concentration on liver function: a population-based study

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