Association between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia among elderly patients with diabetes: a secondary data analysis of the China Health and Retirement Longitudinal Study

Abstract

ObjectivePrevious studies investigating the association between the serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the occurrence of sarcopenia in different populations have yielded inconsistent results. This study aimed to investigate the potential association between TG/HDL-C ratio and sarcopenia among elderly Chinese patients with diabetes.DesignA secondary data analysis.SettingThis was a secondary analysis of data from the China Health and Retirement Longitudinal Study.ParticipantsIn this study, 752 elderly individuals with diabetes were included after excluding individuals aged <60 years old, those with missing data for the assessment of sarcopenia and missing measurements for plasma glucose or glycated haemoglobin.Outcome measuresThe primary information included TG/HDL-C ratio, muscle strength, physical performance, muscle mass and covariables. The association between TG/HDL-C ratio and sarcopenia was assessed using ordinal logistic regression and linear regression analysis.ResultsOn multivariate ordinal logistic regression, among male patients, compared with those with the lowest quartile of TG/HDL-C ratio (≤1.41), those with the highest quartile (>4.71) had a significantly lower risk of more severe sarcopenia (OR 0.24, 95% CI 0.10 to 0.54). Similarly, among female patients, compared with those with the lowest quartile of TG/HDL-C ratio (≤2.07), those with the highest quartile (>5.61) had a significantly lower risk of more severe sarcopenia (OR 0.17, 95% CI 0.07 to 0.44). In multivariate linear regression, male patients with the highest quartile of TG/HDL-C ratio (β=0.36, 95% CI 0.20 to 0.51) had higher muscle mass than those with the lowest quartile. Similarly, female patients with the highest quartile of TG/HDL-C ratio (β=0.31, 95% CI 0.10 to 0.51) had higher muscle mass than those with the lowest quartile.ConclusionsThere was a negative association between TG/HDL-C ratio categorised by quartile and sarcopenia, which indicates that a higher TG/HDL-C ratio may be related to better muscle status.

Triglyceride to high-density lipoprotein cholesterol ratio was negatively associated with relative grip strength in older adults: a cross-sectional study of the NHANES database

“…Wang et al (14) found a negative association between sarcopenia and TG/HDL-C ratio in community-dwelling adults in China. In addition, Lin et al (31) studied older patients with DM in China and found that there was a negative association between TG/HDL-C ratio and sarcopenia, indicating that a higher TG/HDL-C ratio was associated with better muscle status. Differently, in the current study, we found that the TG/HDL-C ratio was negatively associated with the relative grip strength in adults aged ≥60 years old, which indicated that the TG/HDL-C ratio may be suggested to be controlled at an appropriate level in clinical practice and may benefit to prevent and control sarcopenia in older adults.…”

The Impact of Lipid and Glucose Metabolism Disorders on Geriatric Syndromes

“…самый высокий шанс иметь саркопению был в группе ТГ/ЛПВП ≥ 3,9 (ОШ = 2,10, p = 0,001). В Китае при обследовании 752 пациентов старше 60 лет с диабетом получены противоположные результаты: высокое соотношение ТГ/ЛПВП > 4,71 в сравнении с низким ТГ/ЛПВП < 1,41 у мужчин и ТГ/ЛПВП > 5,61 в сравнении с ТГ/ЛПВП < 2,07 у женщин коррелировало с большей мышечной массой у обоих полов (p < 0,001 для мужчин, p = 0,003 для женщин) [14]. Риск саркопении был меньше в группах с высоким соотношением ТГ/ЛПВП как у мужчин, так и у женщин (p ≤ 0,001).…”

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and sarcopenia in individuals with cancer: a cross-sectional study

“…Several studies have reported on sarcopenia and abnormalities of lipid metabolism [ 15 ]. Multiple cross-sectional investigations have revealed an inverse relationship between the triglyceride/HDL-C ratio and relative grip strength, indirectly showing that lipid metabolism monitoring-related indicators reflect muscle loss [ 16 – 18 ]. When investigating lipoprotein subfraction levels in individuals with sarcopenia, a significantly elevated level of non-HDL-C was found, indicating a strong relationship between sarcopenia and abnormalities in lipid metabolism [ 19 ].…”