Association between serum tumor necrosis factor‐α and corticotropin‐releasing hormone levels in women with preterm labor

Vitoratos, N.; Papadias, K; Makrakis, Evangelos; Christodoulakos, George; Panoulis, Konstantinos; Creatsas, George

doi:10.1111/j.1447-0756.2006.00441.x

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…Indeed, MIF and TNF levels were correlated, and both were linked to PTB. Other studies have also found a connection between high serum TNF and PTB [8,9] .…”

Section: Discussionmentioning

confidence: 99%

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Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

Pearce

Grove²,

Bonney³

et al. 2010

Gynecol Obstet Invest

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Background/Aims: To examine the relationship of biological mediators (cytokines, stress hormones), psychosocial, obstetric history, and demographic factors in the early prediction of preterm birth (PTB) using a comprehensive logistic regression model incorporating diverse risk factors. Methods: In this prospective case-control study, maternal serum biomarkers were quantified at 9–23 weeks’ gestation in 60 women delivering at <37 weeks compared to 123 women delivering at term. Biomarker data were combined with maternal sociodemographic factors and stress data into regression models encompassing 22 preterm risk factors and 1st-order interactions. Results: Among individual biomarkers, we found that macrophage migration inhibitory factor (MIF), interleukin-10, C-reactive protein (CRP), and tumor necrosis factor-α were statistically significant predictors of PTB at all cutoff levels tested (75th, 85th, and 90th percentiles). We fit multifactor models for PTB prediction at each biomarker cutoff. Our best models revealed that MIF, CRP, risk-taking behavior, and low educational attainment were consistent predictors of PTB at all biomarker cutoffs. The 75th percentile cutoff yielded the best predicting model with an area under the ROC curve of 0.808 (95% CI 0.743–0.874). Conclusion: Our comprehensive models highlight the prominence of behavioral risk factors for PTB and point to MIF as a possible psychobiological mediator.

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“…Indeed, MIF and TNF levels were correlated, and both were linked to PTB. Other studies have also found a connection between high serum TNF and PTB [8,9] .…”

Section: Discussionmentioning

confidence: 99%

“…Many investigators have shown that acute phase reactants such as C-reactive protein (CRP), and proinflammatory cytokines like IL-6 and tumor necrosis factor-␣ (TNF-␣ ), are potential markers for the infection/inflammation-mediated PTB pathways [4][5][6][7][8][9] . Recently there has been focus on mechanisms that regulate this process, including IL-10 [7] .…”

mentioning

confidence: 99%

Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

Pearce

Grove²,

Bonney³

et al. 2010

Gynecol Obstet Invest

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“…Serum concentrations of IL-1β, 17–19 IL-6, 17,18,20–24 IL-8, 17,20,23 and TNF-α 25,26 are also significantly higher during labor than levels found before labor onset. Hebisch and colleagues 23 reported that IL-6 concentrations during latent labor were significantly lower than concentrations associated with •established• and •advanced• labor.…”

Section: Introductionmentioning

confidence: 88%

Differences in inflammatory markers between nulliparous women admitted to hospitals in preactive vs active labor

Neal

Lamp

Lowe

et al. 2015

American Journal of Obstetrics and Gynecology

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Objectives To determine if labor-associated inflammatory markers differ between low-risk, nulliparous women in pre-active vs. active labor at hospital admission and over time. Study Design Prospective comparative study of low-risk, nulliparous women with spontaneous labor onset at term (N=118) sampled from two large Midwestern hospitals. Circulating concentrations of inflammatory markers were measured at admission and again 2 and 4 hours later: namely, neutrophil and monocyte counts; and serum inflammatory cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor [TNF]-α, IL-10) and chemokines (IL-8). Biomarker concentrations and their patterns of change over time were compared between pre-active (n=63) and active (n=55) labor admission groups using Mann-Whitney U tests. Results Concentrations of IL-6 and IL-10 in the active labor admission group were significantly higher than concentrations in the pre-active labor admission group at all three time points. Neutrophil levels were significantly higher in the active group at 2 and 4 hours after admission. The rate of increase in neutrophils and IL-10 between admission and 2 hours later was faster in the active group (p<0.001 and p=0.003, respectively). Conclusions Circulating concentrations of several inflammatory biomarkers are higher and their rate of change over time since admission is faster among low-risk, nulliparous women admitted to hospitals in active labor, as compared to those admitted in pre-active labor. More research is needed to determine if progressive changes in inflammatory biomarkers might be a useful adjunct to improving the assessment of labor progression and determining the optimal timing of labor admission.

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“…4;6;32-35 While a number of studies have observed a positive association between preterm birth and elevated TNF-α 2;3;28 or preterm birth and indicators of hyperlipidemia, 4;6;35 other studies have observed no such association. 29-31;33;34 In the current study, we observed evidence for such inconsistency as well.…”

Section: Commentmentioning

confidence: 99%

“…While no studies that have focused on early preterm birth have examined the cooccurrence reported here, several studies have examined the relationship between TNF-α and preterm birth 2;3;28-31 or lipid patterns suggestive of hyperlipidemia and preterm birth. 4;6;32-35 While a number of studies have observed a positive association between preterm birth and elevated TNF-α 2;3;28 or preterm birth and indicators of hyperlipidemia, 4;6;35 other studies have observed no such association.…”

Section: Commentmentioning

confidence: 99%

Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Jelliffe‐Pawlowski¹,

Ryckman

Bedell

et al. 2014

American Journal of Obstetrics and Gynecology

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Objective To determine whether pregnancies resulting in early preterm birth (< 30 weeks) were more likely than term pregnancies to have elevated mid-trimester tumor necrosis factor alpha (TNF-α) levels co-occurring with lipid patterns suggestive of hyperlipidemia. Study Design Patterns were examined using stored non-fasted serum samples from 108 California and 734 Iowa singleton pregnancies collected as part of statewide prenatal screening. The frequency of elevated mid-pregnancy serum TNF-α levels and lipid patterns suggestive of hyperlipidemia (e.g. elevated total cholesterol (TC), low-density-lipoproteins (LDLs), or triglycerides (TGs), decreased high-density lipoproteins (HDLs)) (considered independently and by co-occurrence) were compared in pregnancies resulting in early preterm birth to those resulting in term birth using logistic regression models. Results While no differences between preterm and term pregnancies were evident when TNF-α or target lipid abnormalities occurred in isolation, early preterm pregnancies were two to four times more likely than term pregnancies to have elevated TNF-α levels co-occurring with indicators of hyperlipidemia (37.5% versus 13.9% in the California sample (adjusted OR 4.0, 95% CI 1.1 – 16.3) and 26.3% versus 14.9% in the Iowa sample (adjusted OR 2.7, 95% CI 1.1 – 6.3)). Observed differences were not explicable to any maternal or infant characteristics. Conclusion Pregnancies resulting in early preterm birth were more likely than term pregnancies to have elevated mid-pregnancy TNF-α levels co-occurring with lipid patterns suggestive of hyperlipidemia. Patterns offer clues for further study of the signaling of early parturition in preterm birth.

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Association between serum tumor necrosis factor‐α and corticotropin‐releasing hormone levels in women with preterm labor

Cited by 12 publications

References 30 publications

Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

Differences in inflammatory markers between nulliparous women admitted to hospitals in preactive vs active labor

Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

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