Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population

Dai, Xiayun; Yuan, Jing; Yao, Ping; Yang, Binyao; Gui, Lixuan; Zhang, Xiaomin; Guo, Huan; Wang, Youjie; Chen, Weihong; Wei, Sheng; Miao, Xiaoping; Li, Xiulou; Min, Xinwen; Yang, Handong; Fang, Weili; Liang, Yuan; Hu, Frank B.; Wu, Tangchun; He, Meian

doi:10.1007/s10654-013-9829-4

Cited by 73 publications

(53 citation statements)

References 34 publications

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“…Several cross-sectional and longitudinal studies substantially confirm our results, finding an association between UA and worse metabolic profile stronger in women than in men (37)(38)(39)(40)(41)(42)(43)(44). This different association between genders seems to be attributable to several factors, but particularly to the deficiency of estrogens that have uricosuric and metabolic effects (14).…”

Section: Discussionsupporting

confidence: 83%

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Musacchio

Perissinotto

Sartori

et al. 2017

Rejuvenation Research

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Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes. Pro.V.A. is a survey of 3099 individuals aged 65+, focusing on chronic diseases and disability. Uric acid (UA) levels were dichotomized using 6.0 mg/dL (females) and 7.0 mg/dL (males), and multivariate logistic regression models were used to estimate odds ratios (ORs) between HU and single comorbidity. HU prevalence was 21.5% in females and 15.8% in males. HU was associated with most anthropometric and laboratory variables in women, but not in men. After adjustment for age, body mass index, and renal function, HU was independently associated with the presence of cardiovascular diseases in both sexes. In women, HU was associated with hand osteoarthritis (OR = 1.52; 95%CI: 1.12-2.08) and edentulism (OR = 1.31; 95%CI: 1.01-1.71), while resulted protective for osteoporosis (OR = 0.69; 95%CI: 0.53-0.91). In men, HU was significantly related with knee osteoarthritis (OR = 1.72; 95%CI: 1.06-2.79) and chronic obstructive pulmonary disease (OR = 1.60; 95%CI: 1.04-2.45). The presence of ≥4 comorbidities was a stronger determinant of HU in men (OR = 2.54; 95%CI: 1.21-5.37) than in women (ns). Patterns of age-dependent UA increase are markedly different in men and women. HU prevalence is substantial and its association with other diseases is gender specific, connoting a peculiar clinical profile.

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Section: Discussionsupporting

confidence: 83%

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Musacchio

Perissinotto

Sartori

et al. 2017

Rejuvenation Research

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“…In line with previous studies [21][22][23] we reported higher serum uric acid level in women with MetS, comparing to those without MetS. Moreover, in a prospective study conducted by Zurlo et al [24] high serum uric acid levels significantly and independently predicted MetS in older women, but not in men, over a 4.4-year follow-up.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović¹,

Klisić²,

Kavarić³

et al. 2016

Tim Med Glas

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Summary:Aim: The data regarding the prevalence of metabolic syndrome (MetS) among postmenopausal women in Montenegro is limited. Therefore, the aim of this study was to evaluate this prevalence and to examine its association with serum uric acid level, an established cardiometabolic risk factor. Methods: A total of 242 postmenopausal women (aging 43-68) were included. Fasting glucose, lipid parameters, and uric acid were determined with the standard procedure. Blood pressure and anthropometric parameters were obtained. MetS was diagnosed according to the modified US National Cholesterol Education Program Adult Treatment Panel III guidelines. Results: The prevalence of MetS in postmenopausal women was 42.1%. The most prevalent component was abdominal obesity (65.3%), following by hypertension (systolic blood pressure and diastolic blood pressure accounting for 54.1% and 49.2% respectively), hyperglycemia (40.5%), and dyslipidemia (high triglycerides and low HDL-c level accounting for 30.2% and 25.2% respectively). Uric acid levels were significantly higher in postmenopausal women with MetS than in those without MetS (P<0.001). Moreover, a significantly higher number of patients with MetS as compared to subjects without diagnosed MetS across uric acid tertiles was found (χ2=27.02, P<0.001). Conclusion: MetS is highly prevalent among postmenopausal women in Montenegro and correlated with higher uric acid level. Abdominal obesity is the most prevalent feature of the syndrome. This suggests the importance of reducing obesity and lowering uric acid level in prevention of cardiometabolic diseases. Keywords:abdominal obesity, metabolic syndrome, postmenopausal, uric acid Sažetak:Cilj: Nema podataka o prevalenci metaboličkog sindroma (MetS) kod žena u periodu postmenopauze u Crnoj Gori. Stoga je cilj studije bio da se utvrdi ova prevalenca i ispita povezanost MetSa sa mokraćnom kiselinom u serumu, poznatim kardiometaboličkim faktorom rizika. Metode: U studiju su uključene 242 žene u postmenopauzi (starosti 43-68 godina). Glikemija našte, lipidni status i mokraćna kiselina su određivani standardnom procedurom. Mereni su i krvni pritisak i antropometrijski parametri. MetS je dijagnostikovan prema modifikovanim smernicama Američkog nacionalnog programa za edukaciju o holesterolu -Preporuke panela III za lečenje odraslih. Rezultati: Prevalenca MetS-a kod žena u postmenopauzi je iznosila 42,1%. Najučestalija komponenta je bila abdominalna gojaznost (65,3%), potom hipertenzija (sistolna -54,1% i dijastolna -49,2%), hiperglikemija (40,5%), dislipidemija (hipertrigliceridemija -30,2%) i niske vrednosti lipoproteina velike gustine (HDL-holesterol -25,2%). Srednje vrednosti serumske mokraćne kiseline bile su značajno više kod žena sa MetS-om u poređenju sa kontrolnom grupom (P<0,001). Takođe, značajno veći broj ispitanica sa MetS-om je zabeležen u tercilnoj grupi sa najvišom koncentracijom mokraćne kiseline u serumu (χ 2 =27,02; P<0,001). Zaključak: Zabeležena je visoka prevalenca MetS-a kod žena u postmenopauzi u Crnoj Gori, kao ...

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“…Epidemiological and clinical evidence supports the strong link between serum uric acid (SUA) and obesity in different populations. For example, Dai et al 3. performed a cross-sectional study, including 27 009 middle- and old-age Chinese subjects, observed that BMI significantly increased with increasing SUA quintiles.…”

mentioning

confidence: 99%

Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes

Chen

Zhao

et al. 2017

Sci Rep

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We aim to explore the associations between serum uric acid (SUA) and obesity and cardio-cerebrovascular events (CCEs) in Chinese inpatients with type 2 diabetes mellitus (T2DM). 2 962 inpatients with T2DM were stratified into quartile based on SUA concentrations. There were significant increases in the prevalence of both obesity (32.6%, 41.9%, 50.1%, and 62.8%, respectively, p < 0.001 for trend) and severe obesity (0.4%, 0.6%, 0.8%, and 1.3%, respectively, p < 0.001 for trend) across the SUA quartiles. A fully adjusted multiple logistic regression analysis revealed that SUA quartiles were independently associated with the presence of obesity (p < 0.001). The prevalence of CCEs was significantly higher in the obese diabetics than in the nonobese diabetics (16.8% vs. 13.2%, p = 0.027). After controlling for multiple confounding factors, BMI levels were also significantly correlated with the presence of CCEs (p = 0.020). However, there was no significant association of SUA quartiles/SUA levels with the presence of CCEs in T2DM. This study suggested that SUA levels were independently associated with obesity but not with CCEs in patients with T2DM. In selected populations such as subjects with T2DM, the role of uric acid in cardiovascular complications might be attributable to other cardiovascular risk factors, such as obesity.

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Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population

Cited by 73 publications

References 34 publications

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes

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