Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals

Abstract

BackgroundA link between uric acid (UA) levels and cardiovascular diseases has been previously reported. However, its importance as a risk factor is still controversial. This study sought to determine whether elevated serum uric acid levels are associated with cardiovascular disease (CVD) in middle-aged and elderly Chinese individuals.MethodsWe conducted a population-based cross-sectional study in Shanghai, with a total of 8510 participants aged ≥40 years. The CVD included diagnosed coronary heart disease (CHD) and stroke. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.ResultsUric acid levels were positively associated with BMI, waist circumference, triglycerides, systolic blood pressure, diastolic blood pressure, glycohemoglobin, fasting plasma glucose, postprandial 2-hour plasma glucose (all P < 0.05), and negatively associated with HDL-cholesterol (P < 0.001). The prevalence of CVD significantly increased with increasing quartiles of UA in those without MetS group (p trend < 0.001), but not necessarily increased in those with MetS. After adjustment for metabolic syndrome and other cardiovascular risk factors, multivariate logistic regression analysis showed that odds ratios (OR) for CHD, stroke, and CVD in those in the fourth quartiles were 2.34 (95% confidence interval [CI] 1.73 to 3.45), 2.18 (95% CI 1.86 to 3.28), and 2.16 (95% CI 1.80 to 3.29), respectively, compared with those in the first quartile of UA.ConclusionsElevated serum uric acid level was associated with CVD, independent of conventional cardiovascular disease risk factors and metabolic syndrome.

Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome: Results from Fangchenggang Area Male Health and Examination Survey in China

“…In the current study, the rising concentrations of SUA were associated with increased BP significantly. Previous study found that SUA concentrations associated with the risk of cardiovascular disease in middle-age and elderly Chinese, independent of cardiovascular risk factors including components of metabolic syndrome [6]. Some researchers conducted an animal study and found out direct evidence that SUA changes may reflect BP changes [28].…”

“…Serum uric acid (SUA) is the product of purine metabolism, and its concentrations are strictly controlled by the balance between production and exertion [3]. Several studies have reported that high SUA concentrations are associated with hypertension, hyperlipidemia, abdominal obesity and chronic renal disease as it is increasing [1,[4][5][6]. In addition, SUA has proven to be the scavenger of free-radical and exerts a neuroprotective effect [7,8].…”

Study of Serum Uric Acid Level as a Risk Factor and for Evaluating the Severity of Coronary Artery Disease

“…12 Li Qin †, Zhen Yang †, Hongxia Gu, Shuai Luet et al studied association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals and concluded that elevated serum uric acid level was associated with cardiovascular disease, independent of conventional cardiovascular disease risk factors and metabolic syndrome. 13 In our study, the independent adjusted association of hyperuricemia with the severity of CAD was investigated in patients having normal coronary arteries, minimal CAD, 1-vessel, 2-vessel and 3-vessel disease. In our study, patients with smoking history, elevated BMI, hyperlipidaemia with elevated triglyceride, LDL, total cholesterol, elevated fasting blood sugar levels, hyperuricemia was associated with CAD + group.…”

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

“…Two cross-sectional studies from Japan found that the prevalence of carotid atherosclerosis and carotid plaque increasing with elevated UA quartile was prominent in subjects without MetS [39, 40]. A Chinese cohort also found that higher UA predicted higher prevalence of CVD in a MetS(-) group [41]. In line with those results, our study also found that the relationship between FEUA and baPWV or ABI was only significant in MetS (-) participants rather than MetS (+) participants.…”