Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study

Sun, Yanan; Zhang, Haiyan; Tian, Wen; Shi, Liye; Chen, Ling; Li, Jinyang; Zhao, Shijie; Qi, Guoxian

doi:10.1007/s40520-019-01137-2

Cited by 35 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present study found that serum uric acid had different effects on renal prognosis depending on sex. The reason why serum uric acid has a sex-specific effect on diseases such as coronary artery disease [32,33], cardiac hypertrophy [16], IgA nephropathy [18], and others remains unclear. This phenomenon may be related to estrogen, which decreases the ability of urate transport 1 to lower serum uric acid levels and also promotes uric acid urine output [34].…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Choi

Kim

et al. 2020

JCM

View full text Add to dashboard Cite

Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018–1.317; p = 0.028) but not in men (HR, 1.499; CI, 0.964–2.331; p = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Choi

Kim

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Barbieri et al [34] reported that high serum UA levels were associated with severe coronary artery disease in women only. An analysis of 8285 patients showed that there was a statistically significant relationship between the serum UA level and coronary artery disease in women, and, particularly, among women aged ≥80 years [35]. Akasaka et al [36] showed that elevated serum UA levels accelerated yearly eGFR declines and that women were more susceptible to this than men.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females

Choi

Kim

et al. 2020

JCM

View full text Add to dashboard Cite

Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. A total of 4339 patients who diagnosed with IgAN by renal biopsy were retrospectively analyzed. We assessed the association of serum uric acid on IgAN progression using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; p < 0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; p < 0.001) (pinteraction < 0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. In conclusion, the serum uric acid level was an independent risk factor for IgAN progression and its effect was more pronounced among the women compared with that among the men.

show abstract

“…Interestingly, studies in PD have also reported differences in men and women, with one study showing correlations between serum UA levels and disease duration in patients with PD only in men (Andreadou et al, 2009). Other studies have implicated serum UA as a biomarker for coronary artery disease only in women (Sun et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

et al. 2020

View full text Add to dashboard Cite

Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated UA as a molecular biomarker for several neurodegenerative diseases, most notably Parkinson's disease (PD). In this study, we investigated UA levels in clinical samples from HD patients and normal controls (NCs) and assessed potential relationships between UA levels and disease and clinical data. UA levels were measured in plasma (n = 107) and saliva (n = 178) samples from premanifest (pre-HD) and manifest HD patients and control subjects. Gender effects of UA levels were observed in both biofluids, with male patients showing higher UA levels compared to female patients. Comparisons of UA levels across diagnostic groups, separated by gender, revealed that both plasma and salivary UA levels were significantly lower in female pre-HD and manifest HD patients compared to NCs. Salivary levels of UA were also significantly lower in male manifest HD patients versus controls, but not in plasma. Correlations of peripheral UA levels to clinical data also showed differences according to gender. In male HD patients, both plasma and salivary UA levels were significantly negatively correlated with total functional capacity (TFC), while positive correlations were observed with total motor score (TMS). Female HD patients showed a significant positive correlation between plasma UA levels and TMS, while salivary UA levels from female patients were significantly correlated to disease burden. Finally, in a separate cohort, we show that UA levels are decreased in postmortem prefrontal cortical samples (n = 20) from HD subjects compared to matched controls. These findings suggest that decreased levels of UA in the brains of HD patients can be reflected in peripheral fluids, with salivary measures of UA particularly offering significant promise as a potentially relevant, non-invasive biomarker of disease symptoms and burden. Our findings further highlight the impact of sexual dimorphism in HD pathophysiology.

show abstract

Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study

Cited by 35 publications

References 25 publications

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

Contact Info

Product

Resources

About