Association between serum uric acid and carotid atherosclerosis in elderly postmenopausal women: A hospital‐based study

Abstract

Background: Carotid atherosclerosis (CAS) is associated with increased cardiovascular risk and implicated in 20-30% of strokes.Methods: 504 patients were included in this study. The detailed medical history and the results of physical examination, carotid ultrasound examination, and routine laboratory tests were collected. Logistic regression analyses were conducted to analyze the relationship between the SUA and the presence of carotid plaques. And the relationship between SUA and the progression of CAS was analyzed by multiple linear regression. The effect of hormone replacement therapy (HRT) on CAS has also be evaluated.Results: 412 patients (81.7%) had carotid plaques of different sizes by carotid ultrasound examination. We found a positive association between the level of SUA and the probability of having carotid plaque by univariate logistic regression (OR: 2.01, 95% CI: 1.83-2.19, p = 0.003). At 2 years post-discharge, we found that 1 mg/dL increase in SUA levels was expected to 0.946% increase in plaque score and 0.026 cm increase in carotid intima-media thickness, separately. Moreover, patients treated by long-term HRT (≥5 years) had a lower level of SUA and blood lipid and the less change of plaque score and carotid intima-media thickness than patients without HRT. Conclusion:The presence and progression of CAS had significantly positive associations with the level of SUA. And the HRT may have the ability to prevent the presence and progression of CAS. However, the safety and long-term outcome of HRT on CAS should be evaluated in further studies.

National and Provincial-Level Prevalence and Risk Factors of Carotid Atherosclerosis in Chinese Adults

“…For instance, a meta-analysis indicated that male sex, diabetes, and hypertension were common risk factors for increased cIMT and CP . Meta-analyses and prospective studies have reported that serum uric acid levels are significantly associated with increased cIMT and CP . Both cross-sectional and cohort studies have reported a significant association between inflammatory cytokines (ie, white blood cell count and NLR), resting heart rate, platelet count, and MetS and the risk of increased cIMT and CP .…”

“…13 Metaanalyses and prospective studies have reported that serum uric acid levels are significantly associated with increased cIMT and CP. 18,19 Both cross-sectional and cohort studies have reported a significant association between inflammatory cytokines (ie, white blood cell count and NLR), resting heart rate, platelet count, and MetS and the risk of increased cIMT and CP. [20][21][22][23][24][25][26][27][28] Additionally, a crosssectional study conducted among young adults in China revealed that multiple factors, including age, BMI, triglyceride levels, and low-density lipoprotein cholesterol levels were positively associated with increased cIMT and CP.…”

A Relação entre a Relação Ácido Úrico/Albumina e a Espessura Média-Intimal da Carótida em Pacientes com Hipertensão

“… 24 Dong et al encontraram uma associação positiva entre os níveis séricos de ácido úrico e aterosclerose carotídea. 25 Halcox et al relataram uma associação significativa entre a disfunção endotelial e a progressão da EMIC ao longo de um período de acompanhamento de 6 anos. 24 Em um estudo de Tavil et al, a EIMC foi detectada mais alta em hipertensos hiperuricêmicos do que em hipertensos normoisêmicos.…”

“… 24 Dong et al found a positive association between serum uric acid levels and carotid atherosclerosis. 25 Halcox et al reported a significant association between endothelial dysfunction and the progression of CIMT over a 6-year follow-up period. 24 In a study by Tavil et al, the CIMT was detected higher in hyperuricemic hypertensive patients than in normourisemic hypertensive patients.…”

Relationship Between Serum Uric Acid and Carotid Plaque in Patients With Coronary Artery Disease by Sex and Blood Pressure Status

“…27,28 In addition, studies have shown that menopausal women are more likely to develop carotid plaques and have higher SUA levels, especially prominent in late postmenopausal women. 29 Several potential mechanisms may link SUA levels to the incidence of carotid plaques. SUA levels directly stimulate the proliferation and infiltration of vascular smooth muscle cells through the mediation of several important pro-inflammatory factors and signal cascade reactions in the pathogenesis of atherosclerosis.…”