Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Satılmış, Seçkin; Çelik, Ömer; Bıyık, İsmail; Öztürk, Derya; Celik, Kubra Asik; Akın, Fatih; Ayça, Burak; Yalçin, Burçe; Dağdelen, Sinan

doi:10.17305/bjbms.2015.238

Cited by 25 publications

(21 citation statements)

References 36 publications

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“…Inflammation plays a major role in the pathogenesis of these risk factors as well as in post-myocardial remodeling. Further, vitamin D deficiency is associated with increased inflammation, pro-inflammatory cytokines, and atherosclerosis, and vitamin D supplementation may reduce these factors [52–53]. Thus, vitamin D deficiency may play a role in MI.…”

Section: Cardiac Diseasesmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

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Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

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Section: Cardiac Diseasesmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

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“…CVD development and progression commonly involve atherosclerosis buildup and narrowed vessels; the following trials shall indicate the link between these conditions and Vitamin D serum status. Vitamin D deficiency may lead to coronary atherosclerosis, and plaque buildup, but study does not define relationship with the composition [ 101 ]. Meta-analysis conducted for research published on “PubMed” from 2009 onwards does not conclude beneficial effect of Vitamin D on vascular reactivity [ 102 ].…”

Section: Vitamin D and Cvdmentioning

confidence: 99%

The Role of Vitamin D in Diabetes and Cardiovascular Disease: An Updated Review of the Literature

Papandreou

Hamid

2015

Disease Markers

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The dietary reference values for Vitamin D were set primarily considering its role in bone health, but with the discovery of Vitamin D receptors throughout body tissues, new links with other health conditions are now studied, such as for diabetes and cardiovascular diseases (CVD). This paper shall analyze and examine all new research studies carried out, especially in 2013–2015 regarding diabetes mellitus (DM) and cardiovascular diseases (CVD). Vast research has been carried out to establish strong relationship between Vitamin D serum levels, supplementation, diabetes, and CVD. However, the results from researches identified in this paper are disputable. Benefits of Vitamin D adequate levels were recognized from gestational period until later in disease development such as diabetes and/or CVD, but since not all studies are in agreement further investigation is suggested. Researches conducting large randomized controlled trials, exploring range of supplement doses, with variable baseline serum Vitamin D levels, and inclusion of array of associated parameters, are still required to conduct large-scale analysis and draw conclusion as a risk factor. Until then it is possible to conclude that maintenance of serum Vitamin D levels holds advantageous aspects in diabetic and cardiovascular conditions, and people should strive to attain them.

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“…Coronary artery disease (CAD) is characterized by atherosclerotic changes in the arterial wall [1], and different components of the vascular, metabolic, and immune systems are involved in this process. Most of the previous studies investigating morphology of CAD have been focused on changes in the innermost layer of the arterial wall, namely the tunica intima, however over the last few years, there is a growing interest in the role of the other layers in CAD development [2,3].…”

Section: Introductionmentioning

confidence: 99%

Immune cells and vasa vasorum in the tunica media of atherosclerotic coronary arteries

Zorc-Pleskovič

Pleskovič

Vraspir-Porenta

et al. 2018

Bosn J of Basic Med Sci

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In coronary artery disease (CAD), the disruption of the tunica media immune privilege manifests as increased leukocyte infiltration and the formation of vasa vasorum. We aimed to characterize the immune privilege status of the tunica media in human coronary arteries (CAs) with atherosclerotic plaques, by comparing the abundance and composition of immune-cell infiltrates within the individual arterial-wall layers, and by evaluating vasa vasorum neovascularization of the tunica media. The tissue samples were obtained from 36 symptomatic patients with diffuse CAD (aged 60-72 years) who underwent coronary endarterectomy. T and B cells, macrophages and endothelial cells in the CAs were detected by immunohistochemistry. Morphological analysis of CAs showed significant atherosclerotic changes in all specimens. In the media, we observed damage and loss of smooth muscle cells, destruction of the extracellular matrix architecture, and fibrosis. There were 43.3% of immune cells in the intima, 50% in the adventitia, and 6.7% in the media. In the media, 51.1% of the immune cells were T cells (p ˂ 0.001 compared to B cells and macrophages; ANOVA, Scheffe post hoc analysis), 23.5% were B cells, and 25.4% were macrophages. The number of vasa vasorum in the media was 1 in 38.9% of CAs, 2-3 in 36.1%, and ≥4 in 25% of CAs. Our results indicate that, in atherosclerotic CAs, the immune privilege of the media is disrupted by the infiltration of T and B cells, macrophages, and the presence of vasa vasorum.

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Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Cited by 25 publications

References 36 publications

Role of Vitamin D in Cardiovascular Diseases

Role of Vitamin D in Cardiovascular Diseases

The Role of Vitamin D in Diabetes and Cardiovascular Disease: An Updated Review of the Literature

Immune cells and vasa vasorum in the tunica media of atherosclerotic coronary arteries

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