Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis

Li, Bo; Wang, Miaowei; Zhou, Lingyun; Wen, Qian; Zou, Jian

doi:10.1016/j.bjorl.2019.08.007

Cited by 12 publications

(15 citation statements)

References 30 publications

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“…Low vitamin D status has been associated with obesity [ 36 , 37 ] and a recent meta-analysis by Li et al illustrated an association between lower serum vitamin D status and CRS [ 38 ]. Vitamin D supplementation has also been shown to prevent acute respiratory infections [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

Clarhed

Schiöler

Fell

et al. 2022

Eur Arch Otorhinolaryngol

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Purpose Obesity is a growing, global health problem and previous cross-sectional studies have demonstrated an association between obesity and chronic rhinosinusitis (CRS). There is, however, a lack of prospective studies regarding the impact of obesity on developing (new-onset) CRS. Methods Questionnaire-based data (n = 5769) relating to new-onset CRS and Body Mass Index (BMI) were collected in 2013 and 2018 from the Telemark population study in Telemark, Norway. Odds ratios for the risk of new-onset CRS in 2018 in relation to BMI in 2013 were calculated, adjusted for smoking habits, asthma, gender and age. Results When comparing the group with normal weight (18.5 ≤ BMI < 25) with the obese group (BMI ≥ 30), the odds of new-onset CRS was 53% higher [OR 1.53 (1.11, 2.10)] in the obese group. Conclusion CRS is a multifactorial disease with different phenotypes and it is important to consider obesity when assessing patients with CRS in a clinical setting.

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Section: Discussionmentioning

confidence: 99%

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

Clarhed

Schiöler

Fell

et al. 2022

Eur Arch Otorhinolaryngol

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“…[24]. A recent meta-analysis performed by Li et al identified a deficit of this vitamin in a patient with chronic sinusitis [25] suggesting the supplementation with vitamin D as possible useful treatment. Our results confirm that vitamin D can be beneficial to reduce nasal inflammation in patients affected by chronic sinusitis [15].…”

Section: Discussionmentioning

confidence: 99%

A Supplement with Ribes Nigrum, Boswellia Serrata, Bromelain and Vitamin D to Stop Local Inflammation in Chronic Sinusitis: A Case-Control Study

Luca

D’Ascanio

Cingolani

et al. 2023

JCM

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Although chronic sinusitis widely affects the adult population, the treatments currently used did not always satisfactorily solve the symptoms. Traditional therapy with steroids and antibiotics presents risks and benefits and the new drugs, i.e., monoclonal antibody, are valid solutions despite being quite expensive. Natural molecules could be a valid treatment that combines good efficacy and low price. We conducted a case -control study to evaluate the benefit of an oral supplement with Ribes nigrum, Boswellia serrata, Bromelain and Vitamin D on chronic sinusitis symptoms. 60 patients were randomly assigned to one of the three groups: control using nasal steroids only, treatment 1 using nasal steroid and 1 dose of the oral supplement for 30 days and treatment 2 in which patients used nasal steroid and two oral supplement doses daily for 15 days. Conditions of the nasal mucosa and a blood sample (WBC, IgE and CRP) were analyzed at T0, T1 (15 days after treatment) and T2 (30 days after treatment. Patients treated with the supplement improved their nasal findings (hyperemia of mucosa and rhinorrhea) with statistically significant differences from the control. Our preliminary data suggest that the addition of supplement containing Ribes nigrum, Boswellia serrata, Vitamin D and Bromelain to the traditional local therapy (nasal spray with cortisone) can be a supporting therapy to modulate the local inflammation in the nose in patients affected by chronic sinusitis.

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“…Vitamin D is recognized for its anti-inflammation and antiproliferation effects in previous studies ( Stokes and Rimmer, 2016 ). Compared to healthy subjects, patients with CRS presented a lower level of serum vitamin D ( Li et al., 2021 ). Meanwhile, patients with CRSwNP had a significantly lower level of Vitamin D than patients with CRSsNP ( Stokes and Rimmer, 2016 ; Bavi et al., 2019 ; Li et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Current understanding of disease control and its application in patients with chronic rhinosinusitis

Zhou

Yuan

Huang

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundDisease control is a primary treatment goal for patients with chronic rhinosinusitis (CRS). This study aims to summarize the evaluation parameters of disease control and then identify predictors of poorly controlled CRS.MethodsA systematic review of the literature was performed on PubMed, Google Scholar, Scopus, and Cochrane databases to identify studies relating to disease control in CRS.ResultsThe concept of disease control in patients with CRS involved the longitudinal assessment of the disease state and was also an important goal of treatment. As a metric of the disease state, the disease control reflected the ability to keep disease manifestations within certain limits, the efficacy after treatment, and the impact on quality of life. Validated measurements, such as EPOS2012 criteria, EPOS2020 criteria, Sinus Control Test, and patient/physician-reported global level of CRS control, have been utilized in clinical practice. These existing disease control instruments incorporated various disease manifestations and categorized patients into two (well-controlled and poor-controlled), three (uncontrolled, partly controlled, and controlled), or five (not at all, a little, somewhat, very, and completely) control categories. Eosinophilia, high computerized tomography score, bilateral sinonasal disease, asthma, allergic rhinitis, female gender, aspirin intolerance, revision surgery, low serum amyloid A, and specific T cell subtype would predict poorly controlled CRS.ConclusionThe concept of disease control and its application were gradually developed in patients with CRS. The existing disease control instruments demonstrated a lack of uniformity regarding the controlled criteria and included parameters.

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Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis

Cited by 12 publications

References 30 publications

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

A Supplement with Ribes Nigrum, Boswellia Serrata, Bromelain and Vitamin D to Stop Local Inflammation in Chronic Sinusitis: A Case-Control Study

Current understanding of disease control and its application in patients with chronic rhinosinusitis

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