Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Wang, Ying; Sun, Zhengyi; Li, Aipeng; Zhang, Yongsheng

doi:10.1186/s12957-019-1617-5

Cited by 42 publications

(29 citation statements)

References 26 publications

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“…The results derived from this study are promising in terms of deepening of our knowledge of oncogenesis and providing assistance in the future treatment of colon cancer. Several studies have identified that low levels of serum Zn are a risk factor for many kinds of cancer (11,(13)(14)(15)20), including colon cancer (16). Our study further identified that the low level of serum Zn is risk factor of the prognosis of colon cancer.…”

Section: Discussionsupporting

confidence: 75%

Serum zinc level and tissue ZIP4 expression are related to the prognosis of patients with stages I–III colon cancer

Wu¹,

Wu²,

Liu³

et al. 2020

Transl Cancer Res TCR

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Background: It has been reported that serum Zinc (Zn) and tissue ZRT, IRT-like protein 4 (ZIP4) are involved in the oncogenesis of several cancers. However, the relationship between them and the prognosis of colon cancer is unclear.Methods: This was a prospective study including 116 patients with stages I-III colon cancer. The level of serum Zn was measured using a flame atomic absorption spectrometer. The expressions of ZIP4 in cancer tissues were measured using western blot and normal colon tissues from healthy volunteers were used as a control. The primary outcome was 2-year survival and secondary outcomes included the incidences of locoregional recurrence and distant metastasis.Results: The average level of serum Zn in participants was 856.0±322.5 μg/L. Kaplan-Meier survival curves showed that patients with Zn <856.0 μg/L had a significantly higher incidence of distant metastasis (P=0.02) and a significantly lower survival rate than those with Zn ≥856.0 μg/L (P=0.005). Multivariate logistic regression analysis also confirmed that having level Zn <856.0 μg/L was risk factor for the two outcomes. The expression of ZIP4 in cancer tissues was greatly increased as compared with the healthy control, with an average fold change of 2.4. The level of serum Zn was found to be positively correlated with the expression of ZIP4 in tissue. Multivariate logistic regression analysis indicated that increased expression of tissue ZIP4 was an important risk factor for locoregional recurrence (P=0.032), distant metastasis (P=0.039), and overall survival (P=0.035).Conclusions: Both lower levels of serum Zn and increased expression of ZIP4 in tissue are associated with a poorer prognosis of patients with stages I-III colon cancer.

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Section: Discussionsupporting

confidence: 75%

Serum zinc level and tissue ZIP4 expression are related to the prognosis of patients with stages I–III colon cancer

Wu¹,

Wu²,

Liu³

et al. 2020

Transl Cancer Res TCR

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“…Comparable trends were reported in a current meta-analysis with respect to LC [ 73 ]. Here, 27 from 32 studies (including 2,894 cases and 9,419 controls), mostly from Asia (including three European studies), indicated lower serum Zn levels in LC patients than in controls (SMD = −0.88, p < 0.001), while in four and two studies no significant and a positive association, respectively, were recognized.…”

Section: Zincsupporting

confidence: 75%

Are trace element concentrations suitable biomarkers for the diagnosis of cancer?

2021

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Despite advances in cancer research, cancer is still one of the leading causes of death worldwide. An early diagnosis substantially increases the survival rate and treatment success. Thus, it is important to establish biomarkers which could reliably identify cancer patients. As cancer is associated with changes in the systemic trace element status and distribution, serum concentrations of selenium, iron, copper, and zinc could contribute to an early diagnosis. To test this hypothesis, case control studies measuring trace elements in cancer patients vs. matched controls were selected and discussed focusing on lung, prostate, breast, and colorectal cancer. Overall, cancer patients had elevated serum copper and diminished zinc levels, while selenium and iron did not show consistent changes for all four cancer types. Within the tumor tissue, mainly copper and selenium are accumulating. Whether these concentrations also predict the survival probability of cancer patients needs to be further investigated.

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“…Changes in blood zinc has been found in lymphoproliferative disorders as well as in breast, lung and gastrointestinal tumors [29]. Research indicates that the concentrations of zinc in the serum or plasma are low in people with cancer [30], which is consistent with severals study, which confirms that there is a strong relationship between low levels of zinc and cancer [31][32].…”

Section: Zinc In Cancer Diseasesupporting

confidence: 70%

Zinc Supplementation Prevents the Complications of COVID-19 Infection in Cancer Patients

Derouiche

2020

Asian Pac J Cancer Care

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Novel coronavirus” SARS-CoV-2 is rapidly spreading worldwide with a significant mortality rate. In the crisis of COVID-19, cancer patients are seen as a very weak group and this is because of their weakened immune system and hence we aim in this research to show the importance of zinc as a buffer against cancer in COVID-19 for cancer patients. Zinc is an essential trace element that is crucial for growth, development, and the maintenance of immune function. zinc supplementation decreased and generation of inflammatory cytokines. zinc supplementation should have beneficial effects on cancer by decreasing oxidative stress, angiogenesis and induction of inflammatory cytokines while increasing apoptosis in cancer cells. zinc supplementation implemented to improve the antiviral response and systemic immunity in patients with cancer diseases. With the multiple doses approved from zinc, we suggest that there be an supplement in zinc by 50 mg / day for three month with each treatment for cancer patients, in order to strengthen the immune system to prevent the serious effects of COVID19 infection.

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Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Cited by 42 publications

References 26 publications

Serum zinc level and tissue ZIP4 expression are related to the prognosis of patients with stages I–III colon cancer

Serum zinc level and tissue ZIP4 expression are related to the prognosis of patients with stages I–III colon cancer

Are trace element concentrations suitable biomarkers for the diagnosis of cancer?

Zinc Supplementation Prevents the Complications of COVID-19 Infection in Cancer Patients

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