Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren☆☆☆★

Schäfer, Torsten; Heinrich, Joachim; Wjst, Matthias; Adam, H.; Ring, Johannes; Wichmann, Heinz‐Erich

doi:10.1016/s0091-6749(99)70025-4

Cited by 187 publications

(124 citation statements)

References 27 publications

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“…However, in some cases, patients with AD are refractory to these conventional treatments, making it a difficult‐to‐treat disease. Several authors have reviewed the subject of difficult‐to‐treat or difficult‐to‐control AD, stating diverse possible explanations for the problem, such as lack of compliance,1 psychosocial factors,2, 3 skin infections,4, 5 exacerbations triggered by food and aeroallergens,6, 7, 8 and concomitant allergic contact dermatitis (ACD) 9, 10, 11. All these factors may contribute to making the disease difficult‐to‐treat.…”

Section: Introductionmentioning

confidence: 99%

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Boonstra

Rustemeyer

Middelkamp-Hup

2018

Acad Dermatol Venereol

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BackgroundConcomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult‐to‐treat. However, contact sensitization in this patient group has barely been studied.ObjectiveTo study the occurrence of ACD in a population of difficult‐to‐treat AD children and adults.MethodsClinical and patch test information of 48 patients with difficult‐to‐treat AD unresponsive to conventional outpatient treatments was gathered retrospectively. We studied prevalence and relevance of common allergens, performed dynamic patch test analysis and assessed occurrence of polysensitization.ResultsIn 48 patients with difficult‐to‐treat AD, 75% (n = 36/48) had a concomitant contact allergy, and 39% (n = 14/36) of these patients were polysensitized. ACD and polysensitization prevalences were equal amongst children and adults. The most frequent and relevant reactions were seen against wool alcohols, surfactants cocamidopropyl betaine and dimethylaminopropylamine, bichromate and fragrance mix I. Dynamic pattern analysis showed these reactions to be mostly allergic and not irritative of nature.ConclusionDifficult‐to‐treat AD patients frequently suffer from concomitant (multiple) contact allergies, and this may be a reason why the AD turns into a difficult‐to‐treat disease. Awareness of this phenomenon is necessary, as pragmatic implementation of allergen avoidance strategies may be helpful in getting disease control in this population.

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Section: Introductionmentioning

confidence: 99%

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Boonstra

Rustemeyer

Middelkamp-Hup

2018

Acad Dermatol Venereol

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“…22 In addition, the major part of AE patients are dust mite sensitive 23 and the degree of sensitivity to aeroallergens seem to correlate to AE severity. 24 Domestic animals, although being dust mite carriers and sources of household allergens are not usually implied as being responsible for symptoms onset in AE patients. Other cross cut studies, in addition to ours, prove the absence of this association.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for atopic eczema in school children

Wandalsen

Camelo-Nunes

Mello

et al. 2005

Rev. Bras. Saude Mater. Infant.

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Objectives: to study risk factors related to atopic eczema (AE) in school children of São Paulo.Methods: 1972 parents or guardians of 6-7 years old children in the Southern Central area of São Paulo answered to a written questionnaire (standardized questionnaire of the International Study of Asthma and Allergies in Childhood plus a complementary questionnaire regarding family history of asthma and allergies, and exposure to environmental allergens). AE was defined by the presence of an itchy rash in the last year. Risk factors were analyzed through logical regression.Results: the following factors were significantly associated with AE: history of maternal (OR: 4

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“…In a nested case-control study of 2,201 East German schoolchildren age 5-14 years, 75 % of children with AD had ≥1 positive radioallergosorbent test (RAST) compared with only 36 % of children without eczema [39]. Prevalence of allergic sensitization also was associated with AD severity [39].…”

Section: Atopymentioning

confidence: 99%

“…Prevalence of allergic sensitization also was associated with AD severity [39]. A study of 116 adults with AD and 93 nonatopic controls found that serum IgE concentrations were higher in subjects with AD, particularly severe disease with more flares [40].…”

Section: Atopymentioning

confidence: 99%

Atopic Dermatitis: Update on Pathogenesis and Comorbidities

Silverberg

2012

Curr Derm Rep

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Atopic dermatitis (AD) is a significant cause of morbidity and healthcare costs in the United States and worldwide. The prevalence of AD in childhood is rising in the United States and other developed countries for reasons that are not well understood. Similarly, the prevalences of obesity and diabetes are on the rise, which might be contributing toward increased AD. This article reviews the association between AD and other atopic disorders with obesity and diabetes. Furthermore, recently recognized AD comorbidities, including fatty liver disease and erectile dysfunction, are reviewed. Potential mechanisms for the association between AD and metabolic disorders are discussed.

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Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren☆☆☆★

Cited by 187 publications

References 27 publications

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Risk factors for atopic eczema in school children

Atopic Dermatitis: Update on Pathogenesis and Comorbidities

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