The aim of this study was to analyze the quality of life of drug users hospitalized for treatment through the SF-36. We executed a quantitative-descriptive and cross-sectional research. A total of 52 patients (47 men and 5 women) participated in this study. Our results showed low scores on the physical (M=60), (DP=17,23) and mental (M=49), (DP=17,63) concepts in the first application; however, they showed significant improvements in the second application (M=88.6), (DP=10,85) and (M=82.2), (DP=16,72), respectively. The physical functioning (M=69), (DP=18,05) and vitality (M=58.8), (DP=20,04) concept were highlighted with low initial scores. Nevertheless, significant statistical differences were observed at the end of the treatment: (M=95.3), (DP=9,54) and (M=86.8), (DP=13,58), respectively. We concluded that the therapeutic interventions conducted by the multidisciplinary team from the institution contributed to improving these patients’ quality of life perception, as well as cooperated to increase adherence to treatment.