Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome

Demir, Ömer; Akgül, K. Turgay; Akar, Zafer; Çakmak, Özgür; Özdemir, İ.; Bölükbaşı, Ahmet; Can, Ertan; Gümüş, Bilal

doi:10.1080/13685530902777425

Cited by 83 publications

(59 citation statements)

References 29 publications

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“…Other measurements of health including obesity, osteoporosis, cardiovascular disease, cognition, and activities of daily living (ADLs) were not statistically different between normal testosterone and hypogonadal groups. Results from Demir et al supported these findings, and also showed ED was the strongest predictor of severe LUTS in a series of 190 men [12]. Prevalence of metabolic syndrome was also statistically higher in men with severe LUTS (p=0.009).…”

Section: Etiology and Effects Of Hypogonadism In Elderly Mensupporting

confidence: 76%

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Griebling

2013

Curr Transl Geriatr Exp Gerontol Rep

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Testosterone levels tend to decline with advancing age in older men. Some develop symptomatic changes consistent with late onset hypogonadism. Alterations in hormone concentration can have negative impacts on multiple organ systems and physiological processes. This paper focuses on implications for sexual health in elderly men, including changes in libido, erectile function, and sexual performance. Associated concepts in cardiovascular health, cognition and mental health are reviewed. Changes in sexual function have been recognized as early indicators of underlying comorbidities, including cardiovascular diseases, metabolic syndrome, diabetes, depression, and frailty. New research developments on pathophysiology and hormone replacement therapy are highlighted.

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Section: Etiology and Effects Of Hypogonadism In Elderly Mensupporting

confidence: 76%

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Griebling

2013

Curr Transl Geriatr Exp Gerontol Rep

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“…The linkage between MetS and erectile dysfunction (ED) has been highlighted by many studies. [1][2][3] MetS and ED are suggested to share common pathophysiological factors including insulin-resistance, endothelial dysfunction and systemic inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Association of ED with chronic periodontal disease

et al. 2013

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To examine the relationship between chronic periodontal disease (CPD) and erectile dysfunction (ED), the interview sheet including the CPD self-checklist (CPD score) and the 5-item version of the International Index of Erectile Function (IIEF-5) was distributed to 300 adult men who received a comprehensive dental examination. Statistical analyses were performed by the Spearman's rank correlation coefficient and other methods. Statistical significance was accepted at the level of P<0.05. The interview sheets were collected from 88 men (response rate 29.3%, 50.9 ± 16.6 years old). There was a statistically significant correlation between the CPD score and the presence of ED (P=0.0415). The results in the present study suggest that ED is related to the damage caused by endothelial dysfunction and the systematic inflammatory changes associated with CPD. The present study also suggests that dental health is important as a preventive medicine for ED.

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“…IPSS scores increase in parallel with decreases in IIEF scores. On the contrary, Demir et al [19] could not find a significant association between LUTS, hypertension, diabetes mellitus, and abdominal obesity. In their study signifcantly higher frequency of lower urinary tract symptoms were found in cases with hypertriglyceridemia (28.8% vs. 53.8%).…”

Section: Discussionmentioning

confidence: 86%

“…In separate analyses of each risk factors, frequency of ED was found to be increased in the presence of mild (1.9-fold), moderate (3.7-fold), and severe (7.6-fold) ED. [18] In a study by Demir et al [19] a significant degree of concomitancy was detected between LUTS, and ED. They found 2.4-fold higher incidence of ED in patients with LUTS.…”

Section: Discussionmentioning

confidence: 99%

The relationships between metabolic syndrome, erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia

Doğan

Uruç

Aras

et al. 2015

Turkish Journal of Urology

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Objective: To determine the relationship between erectile dysfunction and metabolic syndrome (MetS) in patients with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Material and methods:Seventy-eight patients who were admitted to our outpatient clinic because of BPHrelated LUTS over 40 years of age were included in the study. Patients with LUTS and erectile dysfunction (ED) were evaluated by International Prostate Symptom Score (IPSS) and International Index of Erectile Function-5 (IIEF-5) forms. The National Cholesterol Education Program Adult Treatment Panel III criteria was used for the diagnosis of MetS. LUTS were classified as mild, moderate, and severe according to IPSS and ED was classified as mild-moderate, moderate, and severe according to the IIEF-5. For the evaluation of data, descriptive statistical methods (mean, standard deviation, median, frequency, ratio, minimum, and maximum) and also for the comparison of the variables with non-normal distribution in 3 or more than 3 groups Student's t test, Mann-Whitney U, ANOVA, chi-square, Fisher Exact tests, and Pearson correlation analysis were used. P<0.05 was accepted as the level of statistical significance.Results: Mean age of the patients included in the study was 61.83±9.15. In 34.6% of the patients with MetS, 70.5% of the patients with ED and 37.2% of the patients with severe LUTS were determined. There were no significant differences between the mean age of patients with and without metabolic syndrome (p>0.05). There was a positive correlation with age and severity of LUTS but this relationship was not found to be statistically significant (p>0.05). Mean age of the patients with ED was significantly higher than those without (p<0.001). A statistically significant relationship was not observed between the mean IPSS scores and the severity of LUTS with Mets. However, we observed a weakly positive correlation between triglyceride levels and IPSS. Mean IIEF-5 scores of the patients with MetS were significantly lower than those of the patients without MetS. Severity of ED in the patients with MetS was significantly higher than patients without MetS. The percentage of ED in patients with severe LUTS was found to be statistically higher than other patients with mild, and moderate LUTS. In addition, we found a low degree of negative correlation between IPSS and IIEF-5 scores. Conclusion:In patients with LUTS as a consequence of BPH, when severity of symptoms increases, frequency of MetS increases proportionally and severe ED is observed much more frequently.

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Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome

Abstract: Obesity, high plasma level of FBG and hypertension constitute risk factors for the development of severe LUTS. Metabolic syndrome may play a key role in the pathogenesis in both ED and LUTS. Presence of ED is the most predictor of severe LUTS.

Cited by 83 publications

References 29 publications

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Association of ED with chronic periodontal disease

The relationships between metabolic syndrome, erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia

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