Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Masi, Stefano; Gkranias, Nikolaos; Li, Kawa; Salpea, Klelia D.; Parkar, MH; Orlandi, Marco; Suvan, Jean; Eng, Heng L; Taddei, Stefano; Patel, Kalpesh; Darbar, Ulpee; Donos, Nikos; Deanfield, John; Hurel, SJ; Humphries, Steve E.; D’Aiuto, Francesco

doi:10.2337/dc13-2106

Cited by 33 publications

(26 citation statements)

References 32 publications

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“…Third, in diabetic patients, there is a negative correlation between the degree of endotoxemia and the length of the telomeres in circulating leukocytes (30). Finally, in hemodialysis patients (a patient population frequently characterized by septic episodes and/or systemic inflammatory responses), telomere shortening has been reported in circulating leukocytes (31).…”

Section: Discussionmentioning

confidence: 99%

Sepsis induces Telomere Shortening: a Potential Mechanism Responsible for Delayed Pathophysiological Events in Sepsis Survivors?

Oliveira

Rios

Lima

et al. 2016

Mol Med

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Sepsis survivors suffer from additional morbidities, including higher disk of readmissions, nervous system disturbances and cognitive dysfunction, and increased mortality, even several years after the initial episode of sepsis. In many ways, the phenotype of sepsis survivors resembles the phenotype associated with accelerated aging. Since telomere shortening is a hallmark of aging, we investigated whether sepsis also leads to telomere shortening. Male balb/c mice were divided into two groups: the control group received 100 μl of normal saline intraperitoneally; the sepsis group received 15 mg/kg of bacterial lipopolysaccharide i.p. After 48 hours, animals were sacrificed to collect blood, spleen and kidney. The human component of our study utilized blood samples obtained from patients in the Trauma Department and samples collected 7 days later in those patients who developed sepsis. Telomere length was measured by quantitative PCR. Since oxidative stress is a known inducer of telomere shortening, thiobarbituric acid reactive substances and superoxide dismutase (SOD) activity were analyzed in order to evaluate oxidative stress burden. Induction of endotoxemia in mice resulted in significant telomere shortening in spleen and kidney.Blood cells from patients that progressed to sepsis also exhibited a statistically significant reduction of telomere length. Endotoxemia in mice also induced an earlyonset increase in oxidative stress markers, but was not associated with a downregulation of telomerase protein expression. We conclude that endotoxemia and sepsis induce telomere shortening in various tissues and hypothesize that this may contribute to the pathogenesis of the delayed pathophysiological events in sepsis survivors.

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Section: Discussionmentioning

confidence: 99%

Sepsis induces Telomere Shortening: a Potential Mechanism Responsible for Delayed Pathophysiological Events in Sepsis Survivors?

Oliveira

Rios

Lima

et al. 2016

Mol Med

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“…Besides its relationship with vascular complications, telomere shortening was recently shown to be associated with depression and periodontitis, which are now recognized as new complications of diabetes.…”

Section: Telomere Attrition In Relation To Mortality and Diabetic Commentioning

confidence: 99%

“…29 Cross-sectional studies of T2DM patients showed that those with previous myocardial infarction or atherosclerotic plaques detected by carotid artery ultrasonography had a more markedly reduced LTL than those without either. 20,30 Besides its relationship with vascular complications, telomere shortening was recently shown to be associated with depression 31 and periodontitis, 32 which are now recognized as new complications of diabetes.…”

Section: Telomere Attrition In Relation To Mortality and Diabetic Commentioning

confidence: 99%

Telomere attrition and diabetes mellitus

Tamura

Takubo

Aida

et al. 2016

Geriatrics Gerontology Int

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Type 2 diabetes mellitus (DM) is a disease characterized by dysfunction of various organs. Recent studies have shown a close relationship between DM and telomere attrition in leukocytes. In patients with DM or impaired glucose tolerance, excessive oxidative stress induces damage to telomeres and shortens their length. Furthermore, it is suggested that telomere length is a good surrogate marker for mortality and diabetic complications in DM patients. We recently found that telomere length in pancreatic β-cells is also shortened in DM patients, potentially leading to an impaired capacity for proliferation and insulin secretion, and accelerated cell death. In contrast, leukocyte telomere length has also been reported in patients with obesity or insulin resistance, both of which are frequently associated with type 2 DM. In an animal model, it has been shown that telomere attrition in adipose tissue induces insulin resistance. Taken together, the available data suggest that hyperglycemia, oxidative stress, and telomere attrition in pancreatic β-cells and adipocytes create a vicious cycle that underlies the pathophysiology of type 2 DM. Inhibition of telomere attrition in various organs, including pancreatic β-cells, could be a new approach for preventing the progression of DM and its complications. Geriatr Gerontol Int 2016; 16 (Suppl. 1): 66-74.

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“…According to a recent study, Dental examinations characterized the levels of periodontitis and LTL was measured by PCR after DNA Extraction. Patients with periodontitis demonstrated shorter LTL (P=0.04) in those with a higher prevalence of Type 2 Diabetes (29). Shortened LTL may also be used as a forthcoming measure in those with periodontitis who may or will develop Type 2 Diabetes.…”

Section: The Effect Of Oxidative Stress Shortened Leukocyte Telomerementioning

confidence: 98%

Periodontitis in Patients with Type 2 Diabetes Mellitus

Agarwal¹,

Gangaram²,

Saleem³

2018

AIMDR

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Periodontitis is a chronic, inflammatory disease that is characterized by swollen gums, degradation of jaw structure, and potentially tooth loss. Like Periodontitis, Type 2 Diabetes Mellitus is also highly prevalent and largely multifactorial. Type 2 Diabetes is a condition in which higher than normal blood glucose levels cannot be properly maintained as the body's normal mechanism of maintaining proper blood glucose levels, the release of insulin from pancreatic islet β-cells, becomes ineffective. The purpose of this literature review is to explore the relationship between the incidences of Periodontitis and Type 2 Diabetes. The risk that Type 2 Diabetes poses for the incidence of Periodontitis is analyzed. Patients afflicted with Type 2 Diabetes were found to be approximately three times as likely to eventually suffer from Periodontitis, as well. There is also emerging evidence supporting the correlation between the degree of hyperglycemia and severity of Periodontitis. Potential underlying mechanisms linking the two conditions at the cellular level have been discussed. Immune functioning and cytokine biology are among discussed mechanisms. Recent discoveries have also suggested that Periodontitis may also negatively impact glycemic control. As a result, not only should healthcare providers emphasize oral health as part of Type 2 Diabetes management, but healthy eating and physical activity should be among recommendations that make up Periodontal management.

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Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Cited by 33 publications

References 32 publications

Sepsis induces Telomere Shortening: a Potential Mechanism Responsible for Delayed Pathophysiological Events in Sepsis Survivors?

Sepsis induces Telomere Shortening: a Potential Mechanism Responsible for Delayed Pathophysiological Events in Sepsis Survivors?

Telomere attrition and diabetes mellitus

Periodontitis in Patients with Type 2 Diabetes Mellitus

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