Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents

Zhang, S.; Liu, X.; Kim, J. S.; Ouyang, Fengxiu; Wang, B.; Li, Z.; Tang, Genfu; Xu, Xiping; Pongracic, Jacqueline A.; Wang, X.

doi:10.1111/j.1365-2222.2010.03677.x

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…In addition, because disturbed sleep both increases levels of cytokines involved in inflammation as well as sleep regulation, and shifts the balance between Th1 and Th2 cytokines towards an allergy related (Th2) pattern [20][21][22][23], insufficient sleep may cause physiological responses that are not only involved in exacerbations but also in the development of atopic disease. Additional support for a relation between sleep and allergic disease was recently provided by Zhang et al [34]. In a twin study exploring the relation between sleep time and sensitization to allergens, they found an increased risk of allergen sensitization in adolescents with the shortest sleep duration.…”

Section: Discussionmentioning

confidence: 80%

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Development of atopic disease and disturbed sleep in childhood and adolescence – a longitudinal population‐based study

Jernelöv

Lekander

Almqvist

et al. 2013

Clin Experimental Allergy

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The findings from this study are consonant with the proposition that atopic disease and disturbed sleep are more than passively interrelated. Future research needs to delineate whether causal relationships between these problems are at hand and, if so, at what periods in development this applies. These results point to a need for clinicians to investigate sleep difficulties and treat impaired sleep in paediatric patients with atopic disease.

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Section: Discussionmentioning

confidence: 80%

“…Several lines of reasoning may explain this. Additional support for a relation between sleep and allergic disease was recently provided by Zhang et al [34]. nightmares), which may be most obvious to the person experiencing them, tiredness is accessible for observation by a parent during daytime.…”

Section: Discussionmentioning

confidence: 94%

Development of atopic disease and disturbed sleep in childhood and adolescence – a longitudinal population‐based study

Jernelöv

Lekander

Almqvist

et al. 2013

Clin Experimental Allergy

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“…Indeed, short sleep duration may even set up a positive feedback loop with inflammation since IL-13 and IL-4 given exogenously act to decrease sleep in animal models[119, 120]. In a Chinese twin cohort, we were the first to investigate the potential relationship between sleep duration and allergen sensitization, and we demonstrated that short sleep duration was associated with increasing sensitization to food allergens and aeroallergens in a dose-response manner[121]. These findings require further validation.…”

Section: Sleep Durationmentioning

confidence: 99%

Early life precursors, epigenetics, and the development of food allergy

Hong

Wang

2012

Semin Immunopathol

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Food allergy (FA), a major clinical and public health concern worldwide, is caused by a complex interplay of environmental exposures, genetic variants, gene-environment interactions, and epigenetic alterations. This review summarizes recent advances surrounding these key factors, with a particular focus on the potential role of epigenetics in the development of FA. Epidemiologic studies have reported a number of non-genetic factors that may influence the risk of FA, such as timing of food introduction and feeding pattern, diet/nutrition, exposure to environmental tobacco smoking, prematurity and low birthweight, microbial exposure, and race/ethnicity. Current studies on the genetics of FA are mainly conducted using candidate gene approaches, which have linked more than 10 genes to the genetic susceptibility of FA. Studies on gene-environment interactions of FA are very limited. Epigenetic alteration has been proposed as one of the mechanisms to mediate the influence of early-life environmental exposures and gene-environment interactions on the development of diseases later in life. The role of epigenetics in the regulation of the immune system and the epigenetic effects of some FA-associated environmental exposures are discussed in this review. There is a particular lack of large-scale prospective birth cohort studies that simultaneously assess the inter-relationships of early life exposures, genetic susceptibility, epigenomic alterations and the development of FA. The identification of these key factors and their independent and joint contributions to FA will allow us to gain important insight into the biological mechanisms by which environmental exposures and genetic susceptibility affect the risk of FA, and will provide essential information to develop more effective new paradigms in the diagnosis, prevention and management of FA.

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“…Short sleep duration was associated with increasing risk of sensitization to food and aeroallergens, independently of percentage body fat, in a large sample of adolescent twins in China who completed sleep questionnaires and underwent skin prick testing [15]. Parents of children with eczema reported a significantly greater number of sleep problems compared with healthy controls [16].…”

Section: Insomnia or Short Sleep Durationmentioning

confidence: 99%

Medical comorbidity of sleep disorders in children and adolescents

Lazaratou

Soldatou

Dikeos

2012

Current Opinion in Psychiatry

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Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents

Abstract: Background-Both long and short sleep duration have been associated with obesity, cardiovascular disease, and diabetes. However, there have been no previous studies investigating the potential relationship between altered sleep duration and allergen sensitization.

Cited by 14 publications

References 46 publications

Development of atopic disease and disturbed sleep in childhood and adolescence – a longitudinal population‐based study

Development of atopic disease and disturbed sleep in childhood and adolescence – a longitudinal population‐based study

Early life precursors, epigenetics, and the development of food allergy

Medical comorbidity of sleep disorders in children and adolescents

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