Association Between Single Nucleotide Polymorphisms of miRNAs and Gastric Cancer: A Scoping Review

Pan, Lili; Shi, Yan; Zhang, Jun; Luo, Guanghua

doi:10.1089/gtmb.2021.0258

Cited by 8 publications

(6 citation statements)

References 67 publications

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“…These findings offer crucial insights, laying the groundwork for further exploration. Some miRNAs related to gastric cancer risk and prognosis have already been collected and arranged by academics, including miR-499, miR-146a, and so on ( 30 ), it’s noteworthy that the loci unveiled in our study are not among them. This discrepancy suggests, on the one hand, the significance of our research, and on the other hand, underscores the vast untapped potential within this field.…”

Section: Discussionmentioning

confidence: 81%

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

Wu,

Zhang,

Lyu

et al. 2024

Front. Oncol.

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IntroductionGastric cancer, characterized by high incidence and substantial disease burden, has drawn continuous attention regarding its occurrence and prognosis. Genetics plays a crucial role in influencing the prognosis of gastric cancer, and single nucleotide polymorphisms are closely associated with the occurrence, development, and prognosis of this malignant tumor. Our study aims to conduct survival analysis on patients carrying different single nucleotide polymorphisms, exploring the relationship between miRNA single nucleotide polymorphisms and the prognosis of gastric cancer.MethodsGenetic data from 344 patients in Xianyou, Fujian, formed the basis of our study. We delineated the survival rate and median survival time, utilizing the log-rank test and COX regression analysis as statistical tools.ResultsUpon stratifying the data by sex or operation, it was discerned that the GG genotype at MSH2 rs17502941 independently posed a heightened risk for gastric cancer. Other stratification analyses suggested that the subsequent single nucleotide polymorphisms were correlated with patient prognosis: rs17502941, rs884225, rs1468063, rs7143252, and rs2271738.DiscussionThe outcomes of this study strongly suggest that miRNA polymorphisms significantly influence the survival time of gastric cancer patients and can serve as effective predictors for the prognosis of gastric cancer.

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Section: Discussionmentioning

confidence: 81%

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

Wu,

Zhang,

Lyu

et al. 2024

Front. Oncol.

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“…Single nucleotide polymorphisms (SNPs) can be found in both coding and non-coding genes. Some SNPs associated with miRNA are located in the miRNA promoter region, the miRNA gene sequence, and at the miRNA-binding site of the target gene[ 24 ]. SNPs control the biological activity, transcription, and expression of target genes, which eventually affect the propensity of a person for disease and the efficacy of pharmacological treatments.…”

Section: Dysregulation Of Mirnas In Cancermentioning

confidence: 99%

Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers

Sun,

Kuang,

Zhu

et al. 2024

World J Gastrointest Oncol

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MicroRNAs (miRNAs) have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells (CSCs). The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells (GCSCs). Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of GCSCs. This review summarizes the coding process and biological functions of miRNAs and demonstrates their role and efficacy in gastric cancer (GC) metastasis, drug resistance, and apoptosis, especially in the regulatory mechanism of GCSCs. It shows that the overexpression of onco-miRNAs and silencing of tumor-suppressor miRNAs can play a role in promoting or inhibiting tumor metastasis, apart from the initial formation of GC. It also discusses the epigenetic regulation and potential clinical applications of miRNAs as well as the role of CSCs in the pathogenesis of GC. We believe that this review may help in designing novel therapeutic approaches for GC.

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“…The rs16917496 T > C variant in SET8 is found within the miR502 3′UTR binding pocket which is associated with decreased inhibition in initial breast cancer [ 18 ]. Three miRNAs (miR-146a, 148, and 608) with SNPs rs2910164, rs11170877, and rs4919510, respectively, can influence the development of gastric cancer and its etiology [ 19 ]. miR-126 SNP detected in (Acute Lymphoblastic Leukemia) ALL patients block miRNA processing [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

miR-4716–3p and the target AKT2 Gene/rs2304186 SNP are associated with blood cancer pathogenesis in Pakistani population

Nandwa,

Mehmood,

Mahjabeen

et al. 2024

Non-coding RNA Research

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Association Between Single Nucleotide Polymorphisms of miRNAs and Gastric Cancer: A Scoping Review

Cited by 8 publications

References 67 publications

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers

miR-4716–3p and the target AKT2 Gene/rs2304186 SNP are associated with blood cancer pathogenesis in Pakistani population

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