Association Between Single-Nucleotide Polymorphisms in Pre-miRNAs and the Risk of Asthma in a Chinese Population

Su, Xiaowei; Yang, Yan; Lv, Meili; Li, Lijuan; Wang, Dong; Miao-Liao,; Gao, Linbo; Luo, Haibo; Yunliu,; Cong, Rui-Juan; Liang, Weibo; Li, Yingbi

doi:10.1089/dna.2010.1164

Cited by 34 publications

(25 citation statements)

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“…The GG genotype was associated with reduced risk of asthma in children born to asthmatic mother, whereas the GG genotype was associated with increased risk of asthma in children born to nonasthmatic mothers. In another study, SNPs in pre-miRNA sequence (miR-146a rs2910164 and miR-149 rs2292832) were associated with a reduced risk of asthma in a Chinese population [94]. …”

Section: Mirnas and Asthmamentioning

confidence: 99%

Epigenetics and Childhood Asthma: Current Evidence and Future Research Directions

2012

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Asthma is the most common chronic disease of childhood, affecting one in eight children in the USA and worldwide. It is a complex disease, influenced by both environmental exposures and genetic factors. Although epigenetic modifications (DNA methylation, histone modification and miRNA) can affect transcriptional activity in multiple genetic pathways relevant for asthma development, very limited work has been carried out so far to examine the role of epigenetic variations on asthma development and management. This review provides a brief overview of epigenetic modifications, summarizes recent findings, and discusses some of the major methodological concerns that are relevant for asthma epigenetics.

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Section: Mirnas and Asthmamentioning

confidence: 99%

Epigenetics and Childhood Asthma: Current Evidence and Future Research Directions

2012

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“…The C allele of the rs2910164 G>C polymorphism of miR-146a causes mis-pairing within the miR-146a hairpin, decreased expression of its mature form, and abated expression of its target genes, including TNF receptor-associated factor 6 (TRAF6) and IL-1 receptor-associated kinase 1 (IRAK1) [15]. This functional polymorphism was most extensively studied for its association with various diseases, including temporal lobe epilepsy [16], asthma [17], SLE [9,18], and RA [10]. A very recent study also demonstrated that the rs57095329 A>G polymorphism in the promoter region of miR-146a was associated with SLE in Chinese individuals, and the mutant allele alleviated miR-146a expression through the reduction of its binding affinity for the transcription factor Ets-1 [18].…”

Section: Introductionmentioning

confidence: 99%

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

Wang

et al. 2015

Cell Physiol Biochem

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Background: miR-146a polymorphisms have been involved in susceptibility to multiple diseases. The aim of the present study was to analyze the potential association between two functional miR-146a polymorphisms (rs2910164 and rs57095329) and multiple sclerosis (MS) in the Han Chinese population. Methods: A cohort of 525 patients and 568 healthy controls were genotyped to detect the two polymorphisms by SNaPshot. Results: No significant differences were detected in the distribution of the two miR-146a polymorphisms between the patients and controls (P > 0.05). However, stratification by gender showed a statistically significant difference in the frequency of the genotype rs2910164 between MS patients and control females (P=0.009). Further stratification analysis by subgroup revealed that the miR-146a rs2910164 C allele conferred a higher risk of developing relapsing-remitting MS (RRMS) (P=0.018). In addition, the rs2910164 C allele was significantly associated with increased expression of miR-146a in patients with RRMS (P=0.025). Moreover, patients with the rs2910164 C allele released more TNF-α and IFN-γ, but not IL-1β, compared with individuals carrying the homozygous GG genotype (P < 0.05). Conclusions: Our results provide evidence that rs2910164 may play a role in MS susceptibility in females. The rs2910164 G>C variation may affect the expression of miR-146a and the release of proinflammatory cytokines.

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“…In a case-control study for risk factor for asthma, SNPs demonstrated risk variant rs2910164*C allele (C/G) in the pre-miRNA of miR-146a and rs2292832*T (C/T) miR-149 were significantly associated with lower risk of asthma [12] (Table 1). Corroborating the finding, Jimenez-Morales et al reported rs2910164*C (G/C) miR-146a to be significantly associated with protection against asthma among Mexican females [13].…”

Section: Introductionmentioning

confidence: 99%

Novel Insights into miRNA in Lung and Heart Inflammatory Diseases

Kishore

Borucka

Petrkova

et al. 2014

Mediators of Inflammation

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MicroRNAs (miRNAs) are noncoding regulatory sequences that govern posttranscriptional inhibition of genes through binding mainly at regulatory regions. The regulatory mechanism of miRNAs are influenced by complex crosstalk among single nucleotide polymorphisms (SNPs) within miRNA seed region and epigenetic modifications. Circulating miRNAs exhibit potential characteristics as stable biomarker. Functionally, miRNAs are involved in basic regulatory mechanisms of cells including inflammation. Thus, miRNA dysregulation, resulting in aberrant expression of a gene, is suggested to play an important role in disease susceptibility. This review focuses on the role of miRNA as diagnostic marker in pathogenesis of lung inflammatory diseases and in cardiac remodelling events during inflammation. From recent reports, In this context, the information about the models in which miRNAs expression were investigated including types of biological samples, as well as on the methods for miRNA validation and prediction/definition of their gene targets are emphasized in the review. Besides disease pathogenesis, promising role of miRNAs in early disease diagnosis and prognostication is also discussed. However, some miRNAs are also indicated with protective role. Thus, identifications and usage of such potential miRNAs as well as disruption of disease susceptible miRNAs using antagonists, antagomirs, are imperative and may provide a novel therapeutic approach towards combating the disease progression.

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Association Between Single-Nucleotide Polymorphisms in Pre-miRNAs and the Risk of Asthma in a Chinese Population

Cited by 34 publications

References 29 publications

Epigenetics and Childhood Asthma: Current Evidence and Future Research Directions

Epigenetics and Childhood Asthma: Current Evidence and Future Research Directions

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

Novel Insights into miRNA in Lung and Heart Inflammatory Diseases

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