Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women

Abstract

ABSTRACT.Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs of the OPG gene and associations between these polymorphisms and BMD in 399 Chinese postmenopausal women. BMD was quantified at the lumbar spine (L 2-4 ), femoral neck, and total hip. The g.2264T>C and g.27676A>C SNPs were detected by PCR-RFLP and DNA sequencing methods. A significant association with spine BMD was found for g.27676A>C. The spine BMD value for subjects with genotype AA was significantly higher than those with genotypes GA and AA. No significant association was detected between any of the SNP marker genotypes and the other traits. We conclude that g.27676A>C in the OPG gene affects spine BMD and that the C allele is associated with increased risk for osteoporosis in Chinese postmenopausal women.

Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures

“…1). Finally, a total of 10 studies were enrolled in this meta-analysis 8, 10–15, 23–25 , and a total of 12 SNPs with genotyping data in at least one study were meta-analyzed. Supplementary Table 2 listed the detailed information of recruited studies for this meta-analysis, i .…”

Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

“…The OPG gene has been verified as being involved in bone remodeling, bone mineral homeostasis, and bone matrix composition (Liu et al, 2013) neck, and total hip by DEXA. However, to date, no studies have been published that evaluate the relationship of the 1181G>C and 163A>G SNPs of the OPG gene with BMD in patients with T1DM, despite evidence that these polymorphisms are associated with a loss of bone mass (Shang et al, 2013;Song et al, 2013). Our results, following an examination of the OPG polymorphisms in the T1DM group, demonstrate no association with alterations in BMD and bone biomarkers, but revealed that the levels of ionized calcium were increased in carriers of the OPG 1181G>C polymorphism CC genotype, when compared to carriers of the GG+GC genotypes, suggesting that this polymorphism might favor osteoclastogenesis.…”

“…Data from the literature indicates that OPG is considered to be one of the most important candidate genes for influencing the pathogenesis of osteopathy (Song et al, 2013;Wang et al, 2013;Guo et al, 2014) particularly in postmenopausal women. It is characterized by a reduction in BMD.…”

Relationship between A163G osteoprotegerin gene polymorphism and other osteoporosis parameters in Roma and non-Roma postmenopausal women in eastern Slovakia

“…1 It is a progressive skeletal disease manifested by decreased bone mineral density (BMD) and collateral damage to the bone microarchitecture, which can subsequently lead to impaired skeletal strength and elevated susceptibility to fractures. 2 Multiple and varied factors affect bone mineral density (BMD). These have been summarized by Wang et al 3 as nutritional intake factors (eg, calcium and vitamin D, caffeine, alcohol), body weight, physical activity, and exercise.…”